PASSCODE (Pancreatic Adenocarcinoma Stromal Reprograming ConSortium COordination, Data Management and Education)

PASSCODE（胰腺腺癌基质重编程联盟协调、数据管理和教育）

• 批准号: 10517527
• 负责人: J. Jack LEE
• 金额: $ 97.2万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10517527
• 关键词: American; American Cancer Society; Area; Basic Science; Bioinformatics; Biological Assay; Biometry; Cancer Biology; Cancer Etiology; Cataloging; Cells; Characteristics; Clinical; Clinical Trials Design; Collaborations; Communication; Communities; Computational Biology; Cues; Data; Data Collection; Data Science; Data Storage and Retrieval; Desmoplastic; Diagnosis; Disease; Disease Outcome; Ecosystem; Education; Educational Activities; Educational workshop; Elements; Ensure; Extracellular Matrix; Facility Accesses; Fibroblasts; Funding; Genetic; Goals; Group Meetings; Growth; Heterogeneity; Immune; Infrastructure; Intranet; Logistics; Lymphovascular; Malignant Neoplasms; Malignant neoplasm of pancreas; Mentorship; Mission; Molecular; Outcome; Pancreatic Adenocarcinoma; Pancreatic Ductal Adenocarcinoma; Pathogenesis; Pathology; Patients; Persons; Play; Policies; Procedures; Reagent; Registries; Regulation; Research; Research Activity; Research Personnel; Role; Secure; Short Interspersed Nucleotide Elements; Site; Site Visit; Solid; Specificity; Stromal Neoplasm; System; Therapeutic; Time; Tissues; Transfer Agreement; Translational Research; Twitter; Underrepresented Minority; United States; United States National Institutes of Health; analytical tool; base; biobank; cancer genetics; cloud based; computing resources; data dissemination; data exchange; data harmonization; data management; improved; innovation; material transfer agreement; meetings; member; minority trainee; molecular pathology; mortality; multidisciplinary; multimodal data; neoplastic cell; outreach; pancreas visualization; pancreatic tumorigenesis; programs; research study; response; shared database; social media; success; survival outcome; symposium; tumor; tumor immunology; tumor microbiome; tumor microenvironment; virtual; web site; working group

ABSTRACT A defining feature of Pancreatic ductal adenocarcinoma (PDAC) is the presence of a host stromal response, which is characteristically more robust (“desmoplastic”) than many solid cancers. Stromal elements, including cancer-associated fibroblasts (CAFs) and the extracellular matrix, are pivotal components of the tumor microenvironment (TME) ecosystem in PDAC, which also includes immune cells, the lymphovascular system, and the intra-tumoral microbiome. In recent years the role of the PDAC stroma (and CAFs, in particular) has morphed to one characterized by profound heterogeneity, plasticity, and context-specificity. The newly created Pancreatic Cancer Stromal Reprogramming Consortium (PSRC) will fund a team of six U01 sites to conduct basic and translational research studies on the role of the stroma and other TME constituents in PDAC pathogenesis and outcomes. We have collated a multidisciplinary team of investigators at UT MD Anderson with the goal of creating PASSCODE (Pancreatic Adenocarcinoma Stromal Reprograming ConSortium COordination, Data Management and Education Center), that will serve as an organizing “hub” for coordination, communication and collaboration within the PSRC, and support the newly funded U01 sites. PASSCODE will be co-led by Dr. Anirban Maitra, an expert in PDAC pathology, genetics, and cancer biology, and Dr. J. Jack Lee, an expert in biostatistics, clinical trial design and data science. PASSCODE proposes four aims: First, we will support the administrative infrastructure of the PSRC, and ensure effective communication and collaboration between consortium investigators, the NCI program office and other trans-NCI networks, including facilitating all of the PSRC-approved in-person and virtual meetings. We will also provide operational support for material and data transfer agreements that are germane to the collaborative studies within the PSRC. Second, we will develop a framework for a PSRC “virtual biorepository” as a registry database for shared biospecimen access across the consortium, and develop SOPs for processing, storage, cataloging, and distribution of annotated biospecimens and de-identified clinical, demographic, and molecular information. Third, we will provide centralized data management and data storage capabilities for the PSRC, with the overarching goal of data harmonization and dissemination, within and beyond the consortium. As part of this aim, PASSCODE will provide dedicated biostatistical and bioinformatics analytical tools, and multimodal data visualization for PSRC investigators, including for approved collaborative projects. Fourth, PASSCODE will be responsible for developing and maintaining both a “public facing” PSRC website and other social media outlets, as well as a secure intranet site. We will organize seminars and workshops that highlight progress within the PSRC, and provide a platform for educational/mentorship opportunities, especially with regards to enhancing the participation of underrepresented minority trainees. Cumulatively, PASSCODE’s activities will be geared towards ensuring the success of the consortium’s mission of improving PDAC survival through innovative and collaborative research endeavors.

抽象的 胰腺导管腺癌 (PDAC) 的一个决定性特征是存在宿主基质反应， 其特征是比许多实体癌（包括基质癌）更坚固（“促纤维增生”）。 癌症相关成纤维细胞 (CAF) 和细胞外基质是肿瘤的关键组成部分 PDAC中的微环境（TME）生态系统，其中还包括免疫细胞、淋巴血管系统、 近年来，PDAC 基质（尤其是 CAF）的作用已经得到了改善。 演变成一种具有深刻的异质性、可塑性和情境特异性的特征。 胰腺癌基质重编程联盟 (PSRC) 将资助一个由六个 U01 站点组成的团队进行 关于基质和其他 TME 成分在 PDAC 中的作用的基础和转化研究 我们整理了 UT MD 安德森分校的多学科研究小组与 创建 PASSCODE（胰腺癌基质重编程联盟）的目标 协调、数据管理和教育中心），将作为协调的组织“中心”， PSRC 内部的沟通与协作，并支持新资助的 U01 站点。 由 PDAC 病理学、遗传学和癌症生物学专家 Anirban Maitra 博士和 J. Jack Lee 博士共同领导， 生物统计学、临床试验设计和数据科学方面的专家提出了四个目标：首先，我们将。 支持PSRC的行政基础设施，并确保有效的沟通与协作 联盟调查员、NCI 项目办公室和其他跨 NCI 网络之间的合作，包括促进所有 我们还将为 PSRC 批准的现场会议和虚拟会议提供运营支持。 其次，我们将制定与 PSRC 内的合作研究密切相关的数据传输协议。 PSRC“虚拟生物样本库”框架，作为跨区域共享生物样本访问的注册数据库 联盟，并开发用于处理、存储、编目和分发带注释的生物样本的 SOP 第三，我们将提供集中数据。 PSRC 的管理和数据存储能力，其总体目标是数据协调和 作为这一目标的一部分，PASSCODE 将提供专门的服务。 为 PSRC 研究人员提供生物统计和生物信息学分析工具以及多模式数据可视化， 第四，PASSCODE 将负责开发和批准合作项目。 维护“面向公众”的 PSRC 网站和其他社交媒体渠道，以及安全的内部网站点。 我们将组织研讨会和讲习班，突出 PSRC 内部的进展，并为 教育/指导机会，特别是在加强代表性不足的参与方面 总的来说，PASSCODE 的活动将致力于确保项目的成功。 联盟的使命是通过创新和协作研究努力提高 PDAC 的生存率。