SUPPORT FOR NATIONAL PRIMATE RESEARCH CENTER

支持国家灵长类研究中心

• 批准号: 7668141
• 负责人: JOSEPH E ROBERTSON
• 金额: $ 99.14万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7668141
• 关键词: SUPPORT; NATIONAL; PRIMATE; RESEARCH; CENTER

DESCRIPTION (provided by applicant): The 5-year renewal for Grant P51 RR00163-45 requests funding for programs that support biomedical research at the ONPRC. The application reflects a significant expansion in animal resources and research service cores that is required to support the growth in research programs (external grant funding has doubled during the past 5 years) and to greatly expand the Specific Pathogen Free (SPF) Indian-derived Rhesus Breeding Colony. The aims of this application are to: 1) provide the infrastructure support necessary to conduct advanced biomedical research for which nonhuman primates (NHPs) are used to accelerate progress in understanding human diseases, leading to better health; 2) enhance the Center's resources (scientific expertise, laboratories, animal services, research service cores and equipment) so as to serve as a regional, national and international resource; 3) increase the availability of defined NHPs for biomedical research through support of our programs to expand the SPF Indian-derived Rhesus macaque breeding program that produces animals free of viruses such as herpes B and with defined parentage and genotype; and 4) expand research programs utilizing NHPs in genetics, infectious diseases and vaccine development, aging, neuroscience and women's health. To accomplish these aims, support is requested in four broad areas. Administration and Center Operations provide the administrative and service support that is required for all aspects of the ONPRC. Units include the Director's Office, Business Services, Facilities and Property, and Information Technology and Engineering. Research Infrastructure encompasses the service units that provide the most technologically advanced research support, such as Animal Resources (Business and Research Coordination, Clinical Medicine, NHP Resources, Operations, Pathology Services, Psychological Well Being and Surgery Services), Research Service Cores (Assisted Reproductive Technology, Electrophysiology, Endocrine Services, Flow Cytometry, Imaging and Morphology, Molecular and Cellular Biology, Monoclonal Antibody, Research Library, and Virology) and Special Resources Programs (Alternative NHP Species, Genetics Resource and Informatics, Aging NHPs and Rhesus Breeding). Scientific Resources includes support for the three research divisions that house ONPRC scientists: the Divisions of Pathobiology and Immunology, Neuroscience, and Reproductive Sciences. Funding is also requested for 4 resource-related research projects and the pilot project program. Improvement and Modernization includes funds for equipment and alterations and renovations. The funds requested will provide support for the research infrastructure that is required to conduct the most advanced biomedical research using NHPs as models of human health and disease, and to meet the needs of new emerging areas of research in which the NHP model is critical, such as functional genomics and biodefense initiatives.

描述（由申请人提供）：授予P51 RR00163-45的5年续订要求为支持ONPRC生物医学研究的计划提供资金。该应用程序反映了支持研究计划的增长所需的动物资源和研究核心的显着扩展（外部赠款资金在过去5年中增加了一倍），并大大扩展了特定的无病原体（SPF）印度源自恒河状繁殖殖民地。 该应用的目的是：1）提供进行先进的生物医学研究所需的基础设施支持，而非人类灵长类动物（NHP）用于加速理解人类疾病的进展，从而改善健康； 2）增强中心的资源（科学专业知识，实验室，动物服务，研究服务核心和设备），从而充当区域，国家和国际资源； 3）通过支持我们的计划扩大SPF印度衍生的猕猴育种计划，从而增加了定义的NHP进行生物医学研究，该计划生产了没有病毒的动物，例如B疱疹B，并具有定义的亲父体和基因型； 4）扩大利用NHP的研究计划，用于遗传学，传染病和疫苗开发，衰老，神经科学和妇女健康状况。为了实现这些目标，在四个广泛的领域要求提供支持。管理和中心运营提供了ONPRC各个方面所需的管理和服务支持。单位包括董事办公室，商业服务，设施和财产以及信息技术和工程。 Research Infrastructure encompasses the service units that provide the most technologically advanced research support, such as Animal Resources (Business and Research Coordination, Clinical Medicine, NHP Resources, Operations, Pathology Services, Psychological Well Being and Surgery Services), Research Service Cores (Assisted Reproductive Technology, Electrophysiology, Endocrine Services, Flow Cytometry, Imaging and Morphology, Molecular and Cellular Biology, Monoclonal Antibody,研究图书馆和病毒学）以及特殊资源计划（替代NHP物种，遗传学资源和信息学，NHPS衰老和恒河猴育种）。科学资源包括对拥有ONPRC科学家的三个研究部门的支持：病理学和免疫学，神经科学和生殖科学的分歧。还要求提供4个与资源相关的研究项目和试点项目计划的资金。改进和现代化包括用于设备，更改和翻新的资金。所要求的资金将为研究基础设施提供支持，以使用NHP作为人类健康和疾病的模型进行最先进的生物医学研究，并满足NHP模型至关重要的新的新兴领域的需求，例如功能基因组学和生物幻影倡议。