ALERTNESS AND SMOKING

警觉性和吸烟

• 批准号: 7604762
• 负责人: HARRIET DE WIT
• 金额: $ 0.28万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604762
• 关键词: Acute; Alcohols; Anxiety; Caffeine; Cigarette; Cigarette Smoker; Computer Retrieval of Information on Scientific Projects Database; DRD2 gene; Dextroamphetamine; Dose; Exhibits; Exploratory Behavior; Funding; Future; Genes; Genetic; Genetic Polymorphism; Grant; Heart Rate; Hydrocortisone; Individual; Institution; Laboratories; Laboratory Animals; Link; Measures; Pharmaceutical Preparations; Rate; Rattus; Receptor Gene; Research; Research Personnel; Resources; Self Administration; Self-Administered; Smoking; Source; Stress; Trier Social Stress Test; United States National Institutes of Health; Variant; aged; alertness; dopamine transporter; response; stressor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent studies with laboratory animals link acute stressor reactivity to drug self-administration. Those rats which exhibit more exploratory behavior, greater stress reactivity, and greater sensitivity to drugs are also more likely to self-administer drugs. The first aim of this study is to study inter-individual variation in responses to acute laboratory stress (the Trier Social Stress Test, or TSST) among 100 cigarette smokers aged 18-25. Measures of responses to stress include subjective responses (anxiety), heart rate and cortisol levels. It is hypothesized that greater reactivity to stress will predict future smoking rates. The second aim of this study is to investigate genetic factors related to stress reactivity. Specifically, we will examine the glucocorticorticoid receptor gene (GR), dopamine transporter gene (DAT1), and dopamine D2 receptor gene (DRD2). We hypothesize that the polymorphisms in these genes will predict stress reactivity and smoking escalation. The third aim is to examine reactivity to a single dose (20 mg) of d-amphetamine as a predictor of progression in young cigarette smokers. We will contact subjects at 6 and 12 months after their participation to determine their usage of alcohol, cigarettes and caffeine.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 最近对实验动物的研究将急性应激反应与药物自我给药联系起来。 那些表现出更多探索行为、更大应激反应性和对药物更敏感的老鼠也更有可能自我给药。本研究的首要目的是研究 100 名 18-25 岁吸烟者对急性实验室压力（特里尔社会压力测试，TSST）反应的个体差异。 压力反应的测量包括主观反应（焦虑）、心率和皮质醇水平。据推测，对压力的更大反应将预测未来的吸烟率。 本研究的第二个目的是调查与应激反应相关的遗传因素。 具体来说，我们将检查糖皮质激素受体基因（GR）、多巴胺转运蛋白基因（DAT1）和多巴胺D2受体基因（DRD2）。我们假设这些基因的多态性将预测压力反应和吸烟升级。 第三个目标是检查单剂量（20 毫克）d-苯丙胺的反应性，作为年轻吸烟者病情进展的预测因子。我们将在受试者参与后 6 个月和 12 个月时联系他们，以确定他们的酒精、香烟和咖啡因的使用情况。