Determinants of Drug Preference in Humans--Administrative Supplement

人类药物偏好的决定因素--行政补充

• 批准号: 8641872
• 负责人: HARRIET DE WIT
• 金额: $ 15.78万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2014-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8641872
• 关键词: Acute; Administrative Supplement; Affective; Alcohols; Amphetamines; Area; Attention; Behavioral; Brain; Cannabinoids; Detection; Dextroamphetamine; Emotional; Emotions; Environment; Event; Feeling; Health; Human; Image; Lead; Life; Mediating; Mediator of activation protein; Moods; Nature; Perception; Pharmaceutical Preparations; Placebos; Positive Reinforcer; Procedures; Process; Public Speaking; Research; Role; Science; Sex Characteristics; Social Behavior; Social Environment; Stimulus; Stress; Substance abuse problem; Tetrahydrocannabinol; Visual; Woman; Work; affective neuroscience; base; behavior influence; design; drug of abuse; drug reward; drug seeking behavior; ecstasy; experience; improved; innovation; men; novel; positive emotional state; positive mood; preference; psychologic; response; social; social group

DESCRIPTION (provided by applicant): This project is designed to investigate the effects of drugs of abuse on affective responses to stimuli with positive or negative emotional valence. The studies explore the hypothesis that drugs modulate responses to affective stimuli, and that these effects, in turn, influence the drugs' subjective or reinforcing effects. We will study bidirectional interactions between acute effects of stimulants, alcohol and cannabinoids on affective responses. The studies focus in particular on affective responses to stimuli with social content, to investigate the idea that drugs influence the perception and valence of social stimuli. We will assess the effects of drugs on responses to positive or negative visual images, including images with social or nonsocial content. In addition, we will investigate drug the effects of drugs in real-life positive or negative social situations. In all studies we will compare these emotional responses in men and women. This innovative approach bridges the area of neuropsychopharmacology with affective neuroscience, and if successful, will extend our understanding of the processes that lead to compulsive drug-seeking behavior.

描述（由申请人提供）：该项目旨在调查滥用药物对积极或消极情绪效价刺激的情感反应的影响。这些研究探讨了这样的假设：药物调节对情感刺激的反应，而这些作用反过来又影响药物的主观或强化作用。我们将研究兴奋剂、酒精和大麻素对情感反应的急性影响之间的双向相互作用。这些研究特别关注对社交内容刺激的情感反应，以调查药物影响社交刺激的感知和效价的观点。我们将评估药物对积极或消极视觉图像（包括具有社交或非社交内容的图像）反应的影响。此外，我们还将研究药物在现实生活中积极或消极的社会情境中的影响。在所有研究中，我们将比较男性和女性的这些情绪反应。这种创新方法将神经精神药理学与情感神经科学领域联系起来，如果成功，将扩展我们对导致强迫性药物寻求行为过程的理解。