Influence of menopause on adipose tissue accumulation and function

更年期对脂肪组织积累和功能的影响

• 批准号: 10371466
• 负责人: Kara L. Marlatt
• 金额: $ 12.46万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2022-11-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10371466
• 关键词: Abdomen; Adipocytes; Adipose tissue; Affect; Behavioral; Cardiometabolic Disease; Clinical Research; Cross-Sectional Studies; DNA; Data; Deuterium; Deuterium Oxide; Development Plans; Disease; Educational workshop; Estradiol; Estrogens; Extracellular Matrix; Fibrosis; Funding; Gene Expression; Genes; Grant; Health; Human; Hypertrophy; Impairment; Inflammation; Intervention; Kinetics; Knowledge; Learning; Life; Lipids; Manuscripts; Mass Fragmentography; Measures; Menopause; Metabolic; Modeling; Molecular Profiling; Obesity; Ovariectomy; Pathway interactions; Pharmacology; Plague; Play; Postmenopause; Premenopause; Proteins; Quantitative Reverse Transcriptase PCR; RNA; Research; Risk; Role; Sampling; Scientist; Techniques; Tissue Banks; Tissue Expansion; Tissue Sample; Training; United States; United States National Institutes of Health; Western Blotting; Withdrawal; Woman; Women' s Health; Writing; abdominal fat; cardiometabolic risk; career; career development; design; experience; improved; in vivo; lipid biosynthesis; middle age; novel; pre-clinical; prevent; protein expression; skill acquisition; skills; subcutaneous; symposium; therapy design; transcriptome sequencing

PROJECT SUMMARY Menopause is associated with a decline in estradiol (E2) that coincides with a significant accumulation of abdominal adipose tissue (AT). Yet, little is known about whether the loss of estradiol alters depot-specific AT expansion and function in a manner that promotes abdominal adiposity. It is unknown whether the increased abdominal AT mass that accompanies menopause is due to increased adipogenesis or other mechanisms such as increased hypertrophy or altered lipid storage. Our studies of premenopausal versus estrogen-depleted, postmenopausal women will allow us to examine estrogen withdrawal as a mechanism for adipogenesis (Aim 1) and altered AT function (Aim 2) within the subcutaneous abdominal and femoral depots that has not been explored. Our overarching hypothesis is that E2 loss with menopause promotes abdominal adipogenesis and impair AT function. We would be the first to identify potential novel depot-specific AT pathways in estrogen- depleted, postmenopausal women to explain the accumulation in abdominal adiposity that occurs with menopause. Knowledge gained from our studies will allow us to design and implement more targeted approaches for intervention that prevent abdominal AT accumulation in women. The acquired skills and career development plan in this K01 proposal will allow me to emerge as an independent, NIH-funded scientist in women’s health research that integrates treatments to reduce abdominal adiposity and improve metabolic health in midlife women.

项目概要 更年期与雌二醇 (E2) 下降有关，而雌二醇 (E2) 下降与雌二醇 (E2) 的显着积累同时发生。 然而，对于雌二醇的丧失是否会改变储存特异性 AT 知之甚少。 其扩张和功能是否会促进腹部肥胖，目前尚不清楚。 伴随更年期出现的腹部 AT 肿块是由于脂肪生成增加或其他机制（例如 我们对绝经前与雌激素耗尽的研究表明，肥大增加或脂质储存改变。 绝经后妇女将使我们能够检查雌激素撤退作为脂肪生成的机制（目标 1） 并改变皮下腹部和股骨库内的 AT 功能（目标 2） 我们的首要假设是，绝经期 E2 的减少会促进腹部脂肪的形成。 并损害 AT 功能，我们将是第一个发现雌激素中潜在的新型特异 AT 途径的人。 耗尽的绝经后妇女解释了腹部肥胖的积累 从我们的研究中获得的知识将使我们能够设计和实施更有针对性的措施。 腹部预防女性 AT 积累的干预方法。 K01 提案中的发展计划将使我能够成为一名独立的、由 NIH 资助的科学家 女性健康研究，整合减少腹部肥胖和改善代谢健康的治疗方法 在中年妇女中。

项目成果

NAMS 2021 Utian Translational Science SymposiumSeptember 2021, Washington, DCCharting the path to health in midlife and beyond: the biology and practice of wellness.

NAMS 2021 Utian 转化科学研讨会 2021 年 9 月，华盛顿特区，规划中年及以后的健康之路：健康的生物学和实践。

• 发表时间: 2022-05-01
• 作者: Santoro, Nanette F;Coons, Helen L;El Khoudary, Samar R;Epperson, C Neill;Holt;Joffe, Hadine;Lindsey, Sarah H;Marlatt, Kara L;Montella, Patti;Richard;Rockette;Salive, Marcel E;Stuenkel, Cynthia;Thu
• 通讯作者: Thu