National Canine Muscular Dystrophy Core

国家犬肌营养不良症核心

• 批准号: 7535877
• 负责人: Joe N. Kornegay
• 金额: $ 9.07万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-05 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7535877
• 关键词: Anesthesia procedures; Animal Diseases; Animals; Appendix; Biodistribution; Biological Markers; Biopsy; Blood Chemical Analysis; Breeding; Canis familiaris; Caring; Child; Communities; Consultations; Core Facility; Data Quality; Department of Defense; Development; District of Columbia; Duchenne muscular dystrophy; End Point; Ensure; Estrus; Foundations; Funding; Funding Agency; Goals; Grooming; Histocytochemistry; Histology; Image; Image Analysis; In Situ; Industry; International; Investigational Drugs; Laboratory Animal Medicine; Letters; Magnetic Resonance Imaging; Measures; Medical center; Modeling; Monitor; Mus; Muscle; Muscular Dystrophies; Natural History; Operative Surgical Procedures; Pennsylvania; Performance; Phase; Physiological; Pilot Projects; Pre-Clinical Model; Protocols documentation; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Rodent; Rodent Model; Services; Support of Research; Testing; Therapeutic; Time; Translational Research; United States National Institutes of Health; Universities; Work; career; improved; mdx mouse; parent project; pre-clinical research; preclinical study; programs; response; tool; translational study

The Canine Muscular Dystrophy Core (CMDC) of the proposed UNC-CH Wellstone Center will support pilot projects on well characterized canine DMD models. Many investigators may develop only one therapy all the way to the investigational new drug (IND) phase during their careers. These investigators often will be familiar with, or have ready access to expertise for, rodent models. However, few will have a background with analogous large animal diseases. These preliminary studies should facilitate funding for broader hypothesis or milestone-driven research. This research could ultimately be completed through the UNC-CH National Center for Canine Models of DMD (NCDMD). The CMDC has three interrelated aims that should collectively support research of Wellstone Center investigators and others wishing to utilize canine DMD models in preclinical research. AIM 1. Perpetuate canine models of DMD to meet investigator demands for this important preclinical model. a. Monitor estrus and breed carriers to produce dogs for preclinical studies. b. Work with the UNC-CH Department of Laboratory Animal Medicine to provide specialized care for dystrophic dogs. c. Provide support to UNC-CH and/or NCDMD core facilities to include anesthesia for surgical biopsies and imaging. AIM 2. Work with UNC-CH and/or NCDMD core facilities jo develop and refine biomarkers that can be used to determine efficacy of proposed DMD treatments.: a. Facilitate performance of morphologic, immunohistochemical, ultrastructurai and biodistribution studies needed by investigators. b. Facilitate development of noninvasive functional tests that can be used serially over time to define the natural history and response to treatment of canine DMD models. c. Facilitate establishment of user-defined magnetic resonance imaging (MRI) protocols by providing imaging services and image analysis tools. AIM 3. Collaborate with Wellstone Center investigators and others to conduct pilot projects that bolster translational research focused on therapeutic strategies for DMD.

拟议的UNC-CH Wellstone中心的犬肌营养不良核心（CMDC）将支持 针对良好特征的犬DMD模型的试点项目。许多调查人员可能只会发展一个 在职业生涯中，一直到研究新药（IND）阶段的治疗。这些调查人员 通常会熟悉啮齿动物模型，或者可以准备好使用专业知识。但是，很少有人会有 背景具有类似的大动物疾病。这些初步研究应促进 更广泛的假设或里程碑驱动的研究。这项研究最终可以通过 UNC-CH国家犬DMD犬模型中心（NCDMD）。 CMDC具有三个相互关联的目标 这应该集体支持Wellstone Center调查人员以及希望利用的其他人的研究 临床前研究中的犬DMD模型。 目标1。延续DMD的犬类模型，以满足研究人员对此重要的临床前模型的需求。 一个。监测发情和繁殖载体以生产狗临床前研究。 b。与UNC-CH实验室动物医学系合作，为 营养不良的狗。 c。为UNC-CH和/或NCDMD核心设施提供支持，以包括手术活检的麻醉 和成像。 AIM 2。与UNC-CH和/或NCDMD核心设施一起使用JO开发和完善可用于使用的生物标志物 确定拟议的DMD治疗的功效： 一个。促进形态学，免疫组织化学，超构素和生物分布的性能 研究人员需要的研究。 b。有助于开发无创功能测试，随着时间的流逝，这些测试可以连续使用以定义 自然历史和对犬DMD模型处理的反应。 c。通过提供用户定义的磁共振成像（MRI）协议的促进 成像服务和图像分析工具。 目标3。与Wellstone Center的调查员和其他人合作进行飞行员项目来加强 转化研究的重点是DMD的治疗策略。