Spiral Spectroscopic Human Neuroimaging

螺旋光谱人体神经成像

• 批准号: 7587293
• 负责人: ELFAR ADALSTEINSSON
• 金额: $ 34.28万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7587293
• 关键词: Acceleration; Address; Algorithms; Calibration; Cell membrane; Chemicals; Choline; Coupled; Coupling; Creatine; Data; Engineering; Goals; Histocompatibility Testing; Human; Image; Imagery; Imaging Techniques; Inositol; Life; Magnetic Resonance Spectroscopy; Metabolic; Methods; Monitor; Motivation; Neuroglia; Neurons; Noise; Outcome; Patients; Pattern; Phase; Physiologic pulse; Physiological Processes; Population; Process; Protocols documentation; Protons; Resolution; Scanning; Shapes; Signal Transduction; Slice; Spectrum Analysis; Techniques; Time; Work; absorption; base; cost; design; image reconstruction; improved; in vivo; magnetic resonance spectroscopic imaging; membrane synthesis; neuroimaging; reconstruction; spectroscopic imaging; success; tool; transmission process

DESCRIPTION (provided by applicant): Widespread use of magnetic resonance spectroscopic imaging techniques is hindered by several challenges, including low signal-to-noise ratio (SNR), inhomogeneity of the main field and RF excitation field, cumbersome constraints on imaging time and volumetric coverage, and limited ability to detect and separate signals from coupled or overlapping spectral components. We address these limitations by developing spectroscopic acquisition and processing methods for i) high field strength (3T and 7T), providing higher SNR, increased chemical shift dispersion and simplified coupling patterns; ii) spiral readout gradients that address the spatial encoding limitations in MRSI by offering two orders of magnitude of encoding acceleration; iii) parallel RF transmission to mitigate the severe non-uniformity of RF excitation at high field; and iv) receive coil arrays to improve SNR and enable parallel encoding. Several attractive spectroscopic imaging applications provide a strong motivation for this work, including volumetric, high spatial resolution spectroscopic imaging, greatly reduced scan times for improved patient tolerance, and the incorporation of multidimensional methods to detect subtly different chemical shift species.

描述（由申请人提供）：磁共振光谱成像技术的广泛使用受到了几个挑战，包括低信噪比（SNR），主场和RF激发领域的不均匀性，对成像时间和体积的限制，成像和体积的限制。覆盖范围以及有限的检测和分离信号与耦合或重叠的光谱组件的能力。我们通过为i）高场强（3T和7T）的光谱采集和加工方法来解决这些局限性，从而提供了更高的SNR，增加化学位移分散和简化的耦合模式； ii）通过提供两个编码加速度的数量级来解决MRSI中空间编码局限性的螺旋读数梯度； iii）平行RF传输，以减轻高场处的RF激发的严重不均匀性；和iv）接收线圈阵列以改善SNR并启用并行编码。几种有吸引力的光谱成像应用为这项工作提供了强大的动机，包括体积，高空间分辨率光谱成像，大大减少了扫描时间以提高患者的耐受性，并融合了多维方法以检测微妙的化学移位物种。