META-HEALTH I

元健康I

• 批准号: 7720625
• 负责人: Gary H Gibbons
• 金额: $ 11.71万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7720625
• 关键词: Address; Adipose tissue; Adult; African American; Arteries; Arts; Behavior Therapy; Behavioral; Biochemical; Biochemistry; Biological Factors; Biological Markers; Blood Vessels; Cardiovascular Diseases; Cardiovascular system; Clinical; Clinical Medicine; Clinical Trials; Communities; Community Practice; Complex; Computer Retrieval of Information on Scientific Projects Database; Discipline of Nursing; Disease; Effectiveness; Employee Strikes; Environment; Epidemic; Functional disorder; Funding; Gene Expression; Genetic; Grant; Health; Human; Hypertension; Inflammation; Institution; Insulin Resistance; Intervention; Joints; Life Style; Link; Mediating; Mediator of activation protein; Metabolic; Metabolic syndrome; Modification; Molecular; Molecular Profiling; Nurses; Obesity; Obesity associated cardiovascular disease; Other Genetics; Pathway interactions; Patients; Physiological; Physiology; Play; Population; Psychology; Range; Relative (related person); Research; Research Personnel; Resources; Risk; Role; Series; Social Aspects of Cancer; Source; Staging; Training and Education; United States National Institutes of Health; Universities; Vascular Diseases; adipokines; age group; base; cardiovascular disorder risk; cohort; disorder risk; epidemiology study; ethnic difference; innovation; insight; lifestyle intervention; mRNA Expression; medical schools; novel; patient oriented; programs; psychosocial; research study; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Over the past decade, there has been an explosive increase in obesity among all age groups within the US population. This epidemic is particularly problematic among African Americans in the Southeast. Although genetic factors play a contributory role, it is postulated that ethnic disparities in obesity and obesity-related cardiovascular disease (CVD) is related to a dynamic interplay between biological factors and the behavioral response to the unique environmental context within ethnic communities. Obesity is often associated with perturbations in the metabolic and physiologic milieu. A cluster of obesity-related abnormalities has been defined as the "Metabolic Syndrome". The CVD complications of obesity appear to be related to the capacity for adipose tissue itself to generate "adipokines" that directly predispose to insulin-resistance, endothelial dysfunction, inflammation and vascular disease. The proposed program will use state-of-the-art approaches to define potential ethnic differences in the profile of metabolic, physiologic and biochemical features associated with obesity as well as the salutary responses to lifestyle modification. The proposed program uses a multi-disciplinary strategy to systematically characterize potential ethnic differences in obesity-related CVD by drawing upon the fields of psychology, physiology, biochemistry, nursing and clinical medicine. In a thematic series of inter-related studies, our Program's research plan ranges from: epidemiology studies within the ethnic communities, to patient-centered clinical trial interventions within ethnic community practices, to the analysis of novel biomarkers of human pathobiology. This collaborative multi-investigator team is built upon a complementary partnership between the Morehouse School of Medicine and Emory University. This partnership shares a joint commitment to address the striking ethnic disparities in the high-risk CVD population that we serve. The specific aims are: Aim 1: Define the relative influence of psychosocial/cultural factors and biological mediators as determinants of ethnic disparities in obesity and the metabolic syndrome in a population-based bi-racial cohort. Aim 2: Define the effectiveness of patient-targeted behavioral interventions to enhance the health of African American patients with the Metabolic Syndrome in the context of community-based clinical practices. Aim 3: To assess the impact of innovative lifestyle intervention strategies on conventional and novel biomarkers of vascular disease risk in African-Americans. Aim 4: To enhance the education/training of fellows/practitioners engaged in CVD disparities research/practice and promote partnerships that enhance cardiovascular health within ethnic communities. A major objective of this project is to characterize the abnormalities of vascular gene expression occurring in early, subclinical stages of vascular disease, as assessed by large artery function, in adult obesity and to assess its correlates and the potential pathobiological mediating pathways between vascular dysfunction and vascular gene expression. While compelling evidence indicates that genetic and other biological factors predispose to obesity and hypertension, these common, co-occurring disorders likely reflect a complex interplay between biological factors and the psychosocial and cultural environment. Taken together, this series of studies will be among the first to link changes in human vascular mRNA expression profiles with physiologic alterations in vascular function and obesity. Overall, it is anticipated that these experiments will provide new insights into the molecular basis of vascular stiffness and endothelial dysfunction in high-risk African American obese subjects. Obesity is often associated with perturbations in the metabolic and physiologic milieu. A cluster of obesity-related abnormalities has been defined as the "Metabolic Syndrome". The CVD complications of obesity appears to be related to the capacity for adipose tissue itself to generate "adipokines" that directly predispose to insulin-resistance, endothelial dysfunction, inflammation and vascular disease. The proposed program will use state-of-the-art approaches to define potential ethnic differences in the profile of metabolic, physiologic and biochemical features associated with obesity as well as the salutary responses to lifestyle modification The proposed program uses a multi-disciplinary strategy to systematically characterize potential ethnic differences in obesity-related CVD by drawing upon the fields of psychology, physiology, biochemistry, nursing and clinical medicine. In a thematic series of inter-related studies, our Program's research plan ranges from: epidemiology studies within the ethnic communities, to patient-centered clinical trial interventions within ethnic community practices, to the analysis of novel biomarkers of human pathobiology. This collaborative multi-investigator team is built upon a complementary partnership between the Morehouse School of Medicine and Emory University. This partnership shares a joint commitment to address the striking ethnic disparities in the high-risk CVD population that we serve. The specific aims are: Aim 1: Define the relative influence of psychosocial/cultural factors and biological mediators as determinants of ethnic disparities in obesity and the metabolic syndrome in a population-based bi-racial cohort. Aim 2: Define the effectiveness of patient-targeted behavioral interventions to enhance the health of African-American patients with the Metabolic Syndrome in the context of community-based clinical practices Aim 3: To assess the impact of innovative lifestyle intervention strategies on conventional and novel biomarkers of vascular disease risk in African-Americans Aim 4: To enhance the education/training of fellows/practitioners engaged in CVD disparities research/practice and promote partnerships that enhance cardiovascular health within ethnic communities

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在过去的十年中，美国人口中所有年龄段的肥胖症都在爆炸性增加。在东南部的非洲裔美国人中，这种流行病尤其有问题。尽管遗传因素起着贡献作用，但据推测，肥胖和与肥胖相关的心血管疾病（CVD）的种族差异与生物学因素之间的动态相互作用与对种族社区中独特环境环境的行为反应之间的动态相互作用有关。 肥胖通常与代谢和生理环境中的扰动有关。一群与肥胖相关的异常已被定义为“代谢综合征”。肥胖症的CVD并发症似乎与脂肪组织本身产生“脂肪因子”的能力有关，这种“脂肪因子”直接易受胰岛素辨认，内皮功能障碍，炎症和血管疾病。拟议的计划将使用最先进的方法来定义与肥胖相关的代谢，生理和生化特征以及对生活方式修改的有益反应的潜在种族差异。 拟议的计划使用多学科策略来系统地表征与肥胖相关的CVD的潜在种族差异，通过利用心理学，生理学，生物化学，护理和临床医学领域。在一系列主题相关研究中，我们的计划的研究计划范围从：种族社区内的流行病学研究到族裔社区实践中以患者为中心的临床试验干预措施到人类病理生物学的新生物标志物的分析。这个合作的多入侵者团队建立在莫尔豪斯医学院和埃默里大学之间的互补伙伴关系基础上。该合作伙伴关系共同承诺解决我们服务的高风险CVD人群中的族裔差异。具体目的是： 目标1：定义心理社会/文化因素和生物学介体的相对影响，为肥胖症中种族差异的决定因素和基于人群的双种族群体中的代谢综合征。 AIM 2：定义针对患者的行为干预措施的有效性，以增强基于社区的临床实践的背景下的非裔美国人患者的健康。 目标3：评估创新的生活方式干预策略对非裔美国人血管疾病风险的常规生物标志物的影响。 目标4：增强从事CVD差异研究/实践的研究员/从业人员的教育/培训，并促进伙伴关系，以增强族裔社区的心血管健康。 该项目的一个主要目的是表征在早期的血管疾病亚临床阶段发生的血管基因表达的异常，如大动脉功能，成人肥胖症所评估，并评估其相关性及其潜在病原体介导途径之间的潜在病原体介导途径。 尽管令人信服的证据表明，遗传和其他生物学因素易于肥胖和高血压，但这些常见的，同时发生的疾病可能反映了生物学因素与心理社会和文化环境之间的复杂相互作用。 综上所述，这一系列研究将是第一个将人血管mRNA表达谱变化与血管功能和肥胖症的生理改变联系起来的研究之一。总体而言，可以预料，这些实验将为非裔美国肥胖受试者中血管僵硬和内皮功能障碍的分子基础提供新的见解。 肥胖通常与代谢和生理环境中的扰动有关。一群与肥胖相关的异常已被定义为“代谢综合征”。肥胖症的CVD并发症似乎与脂肪组织本身产生“脂肪因子”的能力有关，这种“脂肪因子”直接易受胰岛素辨认，内皮功能障碍，炎症和血管疾病的影响。拟议的计划将使用最先进的方法来定义与肥胖相关的代谢，生理和生化特征以及对生活方式修改的有益反应的潜在种族差异 拟议的计划使用多学科策略来系统地表征与肥胖相关的CVD的潜在种族差异，通过利用心理学，生理学，生物化学，护理和临床医学领域。在一系列主题相关研究中，我们的计划的研究计划范围从：种族社区内的流行病学研究到族裔社区实践中以患者为中心的临床试验干预措施到人类病理生物学的新生物标志物的分析。这个合作的多入侵者团队建立在莫尔豪斯医学院和埃默里大学之间的互补伙伴关系基础上。该合作伙伴关系共同承诺解决我们服务的高风险CVD人群中的族裔差异。具体目的是： 目标1：定义心理社会/文化因素和生物学介体的相对影响，为肥胖症中种族差异的决定因素和基于人群的双种族群体中的代谢综合征。 目标2：在基于社区的临床实践的背景下，定义针对患者的行为干预措施的有效性，以增强非裔美国人患者的健康状况 目标3：评估创新的生活方式干预策略对非裔美国人血管疾病风险的常规生物标志物的影响 目标4：增强从事CVD差异研究/实践的研究员/从业人员的教育/培训，并促进伙伴关系，以增强族裔社区的心血管健康