From Neighborhoods to Neurons and Beyond
从邻里到神经元及其他
基本信息
- 批准号:7431475
- 负责人:
- 金额:$ 230.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-09-30 至 2012-08-31
- 项目状态:已结题
- 来源:
- 关键词:Academic achievementAcademyAccountingAddressAdolescenceAdolescentAdolescent BehaviorAdolescent DevelopmentAdultAffectiveAfrican AmericanAgeAge of OnsetAge-YearsAggressive behaviorAgreementAlcohol or Other Drugs useAlcoholsAllelesAmericanAmygdaloid structureAnalysis of VarianceAnimal ModelAnnual ReportsAnteriorAnxietyApplications GrantsArchivesAreaArizonaArousalAttention deficit hyperactivity disorderAwardBackBehaviorBehavior ControlBehavior DisordersBehavior assessmentBehavior monitoringBehavioralBehavioral GeneticsBeliefBiochemistryBioinformaticsBiologic CharacteristicBiologicalBiological FactorsBiological PsychiatryBiologyBirthBlinkingBloodBody mass indexBrainBrain imagingBrain regionBudgetsCRH geneCaliforniaCaregiversCaringCaucasiansCaucasoid RaceCell NucleusCellular biologyCensusesCerebral cortexCharacteristicsChicagoChildChild BehaviorChild DevelopmentChild RearingChildhoodChromatinClassClinicalClinical TrialsCognitionCognitiveCognitive ScienceCollaborationsCollectionCommunitiesComplexComputer information processingComputersConditionConduct DisorderConsentConsultationsCorticotropin-Releasing HormoneCreativenessCrimeCriminologyDNADNA MethylationDNA SequenceDNA copy numberDataData AnalysesData CollectionDatabasesDepthDevelopmentDisadvantagedDisciplineDiseaseDisease regressionDisruptionDistalDistrict of ColumbiaDizygotic TwinsDoctor of PhilosophyEcologyEconomicsEducational process of instructingEducational workshopElderlyElementsEmotionalEmotionsEnsureEnvironmentEnvironmental ExposureEnvironmental Risk FactorEpigenetic ProcessEquationEthnic groupExperimental PsychologyExposure toFaceFailureFamilyFamily CharacteristicsFamily ProcessFamily StudyFarming environmentFemaleForce of GravityFoundationsFrequenciesFunctional Magnetic Resonance ImagingFunctional disorderFundingFutureGenderGene ExpressionGene TargetingGenesGeneticGenetic ModelsGenetic Predisposition to DiseaseGenetic ResearchGenetic StructuresGenetic VariationGenomeGenomicsGenotypeGlucocorticoid ReceptorGrantGrowthHandHeadHealthHealth Services AccessibilityHeritabilityHeterogeneityHippocampus (Brain)HispanicsHome environmentHourHouseholdHumanHuman DevelopmentHuman GeneticsHypothalamic structureImageImaging TechniquesImmunoprecipitationImpulsivityIndividualIndividual DifferencesInfantInformed ConsentInterventionInterviewInvestigationIowaJointsJournalsKnowledgeLaboratoriesLate EffectsLawsLeadLifeLife Cycle StagesLinear ModelsLinkLongevityLongitudinal StudiesLos AngelesLow incomeMagnetic Resonance ImagingMammalian GeneticsMapsMaternal BehaviorMeasurementMeasuresMedialMediatingMediationMedicineMental DepressionMental disordersMentored Research Scientist Development AwardMessenger RNAMetalsMethodologyMethodsMethylationMichiganMinorityMinority GroupsModelingModificationMolecularMolecular GeneticsMolecular ProfilingMonitorMonozygotic TwinningMonozygotic twinsMothersNational Institute of Mental HealthNatureNeighborhoodsNeuraxisNeuro-Oncological Ventral Antigen 2NeurobiologyNeuronsNeuropsychologyNeurosciencesNeurosciences ResearchNew YorkNicotineNicotine DependenceNucleotidesNumbersObject AttachmentOutcomePaperParent-Child RelationsParental ConsentParenting behaviorParentsParticipantPathway interactionsPatient Self-ReportPatternPediatricsPeer GroupPeer ReviewPerceptionPersonal SatisfactionPersonalityPersonsPharmacologyPhasePhase I Clinical TrialsPhase II Clinical TrialsPhase III Clinical TrialsPhenotypePilot ProjectsPituitary-Adrenal SystemPlayPopulationPopulation HeterogeneityPositioning AttributePositron-Emission TomographyPovertyPrefrontal CortexPrevalencePrevention programPreventive MedicineProblem behaviorProcessProhibitPromoter RegionsPsychiatristPsychiatryPsychologistPsychologyPsychopathologyPsychophysiologyPsychosocial FactorPublicationsPublished CommentPublishingPurposeQualifyingRaceRangeRateRattusReceptor GeneRecording of previous eventsRecruitment ActivityRegulationRelative (related person)ReportingResearchResearch DesignResearch Ethics CommitteesResearch PersonnelResearch Project GrantsResourcesRewardsRiskRisk FactorsRoleRosaRouteRuralSASSalesSamplingScanningSchoolsScienceSeedsSeminalSeriesSex CharacteristicsSiblingsSingle ParentSiteSocial ChangeSocial ClassSocial ControlsSocial DisorganizationsSocial EnvironmentSocial PsychologySocial SciencesSocial isolationSocioeconomic StatusSociologySourceStagingStandards of Weights and MeasuresStatistical MethodsStimulusStressStressful EventStructureStudentsSubstance Use DisorderSupervisionSurveysSystemTechniquesTestingThinkingTimeTimeLineTobaccoTrainingTranslatingTwin Multiple BirthTwin StudiesUnited States National Institutes of HealthUniversitiesUpdateVariantVietnamViolenceVisitWeekWorkWritingYouthadolescent smokingadolescent substance useage effectage relatedanalytical methodanti socialbasebiological researchbisulfitebrain researchcareercingulate cortexclinically significantcohortcomputerized data processingcontextual factorscostcost effectivedata integrationdata qualitydaydensitydeprivationdesigndetectordeviantearly onsetemotion regulationemotional stimulusendophenotypeenvironmental stressoressaysethnic minority populationexperiencefallsfather rolefollow-upfrontal lobegenetic analysisgenetic associationgenetic risk factorgenetic varianthealth disparityhigh schoolhuman subjectinfancyinnovationinterdisciplinary approachinterestlife course persistentlow socioeconomic statusmalemiddle agemigrationmodel designmortalitymultidisciplinaryneural circuitnonhuman primatenovelparental monitoringpeerpeer influenceprofessorprogramspromoterprotective effectpsychobiologicpsychogeneticspsychologicpsychosocialracial and ethnicracial and ethnic disparitiesracial differenceracial discriminationracial/ethnic differenceresearch studyresilienceresponsesexsocialsocial attachmentsocial cognitive theorysocioeconomicssoftware developmentstemsymposiumteachertheoriestooltraittrendunderage drinkingwillingnessyoung adult
项目摘要
The purpose of this three-phase study is to conduct a multidisciplinary-based investigation of the effects of
individual, family, peer, and neighborhood characteristics on individual differences in adolescent problem
behavior. Phase I consists of an in-school assessment of approximately 7,000 6th – 8th graders in 10
socioeconomically and racially and ethnically diverse schools in the Chicago Public School system. The
purpose of Phase I is to obtain data on environmental and psychosocial factors that may account for
socioeconomic and racial and ethnic differences in problem behavior. Phase II consists of a target sample of
400 full-, half- and unrelated sibling pairs drawn from the original Phase I study who, along with their primary
caregivers, will be brought to the University of Chicago for detailed neuroscience and behavioral assessments.
The primary purpose of Phase II is to identify the environmental, biological, and psychosocial variables that
account for individual differences in problem behavior, and to further determine whether these effects are
genetically or environmentally mediated. Phase III consists of an fMRI investigation using a target sample of
60 concordant and 40 extreme discordant sibling pairs drawn from the Phase II study. The primary purpose of
Phase III is to identify the neurobiological substrates that account for within-pair differences in behavior, and to
determine the extent to which nonshared environmental factors account for individual differences in
neurobiological functioning. A small pilot study of 20 extremely discordant sibling pairs from Phase III will
investigate whether environments alter gene expression via changes in DNA methylation. Because this nested
design uses a bioecological framework to measure risk and protective factors at multiple levels of analysis-
“from neighborhoods to neurons and beyond”- the resulting data uniquely allows for the investigation of
mediating and moderating effects among environmental, psychosocial, biological, and genetic factors on
individual differences in problem behavior.
这项三阶段研究的目的是对以下因素的影响进行多学科调查:
个人、家庭、同伴和邻里特征对青少年问题个体差异的影响
第一阶段包括对 10 名大约 7,000 名 6 至 8 年级学生进行校内评估。
芝加哥公立学校系统中社会经济、种族和民族多样化的学校。
第一阶段的目的是获取可能解释的环境和社会心理因素的数据
第二阶段包括失业和种族及民族差异问题行为的目标样本。
400对从最初的第一阶段研究中抽取的全血缘、半血缘和无血缘关系的兄弟姐妹,以及他们的主要兄弟姐妹
护理人员将被带到芝加哥大学进行详细的神经科学和行为评估。
第二阶段的主要目的是确定环境、生物和社会心理变量
考虑问题行为的个体差异,并进一步确定这些影响是否是
第三阶段包括使用目标样本进行功能磁共振成像研究。
从第二阶段研究中抽取的 60 对一致和 40 对极端不一致的兄弟姐妹。
第三阶段是确定导致配对内行为差异的神经生物学基础,并
确定非共享环境因素在多大程度上解释个体差异
一项针对 III 期中 20 对极度不一致的兄弟姐妹的小型试点研究将进行。
研究环境是否通过 DNA 甲基化的变化改变基因表达,因为这是嵌套的。
设计使用生物生态框架来衡量多个分析层面的风险和保护因素-
“从邻里到神经元及其他”——所产生的数据独特地允许对
环境心理、社会、生物和遗传因素之间的中介和调节作用
问题行为的个体差异。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Community Violence Exposure and Adolescent Delinquency: Examining a Spectrum of Promotive Factors.
社区暴力暴露和青少年犯罪:检查一系列促进因素。
- DOI:
- 发表时间:2016-01
- 期刊:
- 影响因子:2
- 作者:Chen, Pan;Voisin, Dexter R;Jacobson, Kristen C
- 通讯作者:Jacobson, Kristen C
Do Dog Behavioral Characteristics Predict the Quality of the Relationship between Dogs and Their Owners?
狗的行为特征可以预测狗与其主人之间的关系质量吗?
- DOI:
- 发表时间:2013
- 期刊:
- 影响因子:0
- 作者:Hoffman, Christy L;Chen, Pan;Serpell, James A;Jacobson, Kristen C
- 通讯作者:Jacobson, Kristen C
Community Violence Exposure and Sexual Behaviors in a Nationally Representative Sample of Young Adults: The Effects of Race/Ethnicity and Gender.
全国代表性年轻人样本中的社区暴力暴露和性行为:种族/民族和性别的影响。
- DOI:
- 发表时间:2015
- 期刊:
- 影响因子:1.6
- 作者:Voisin, Dexter R;Chen, Pan;Fullilove, Robert;Jacobson, Kristen C
- 通讯作者:Jacobson, Kristen C
Developmental trajectories of substance use from early adolescence to young adulthood: gender and racial/ethnic differences.
从青春期早期到成年早期物质使用的发展轨迹:性别和种族/民族差异。
- DOI:
- 发表时间:2012-02
- 期刊:
- 影响因子:0
- 作者:Chen, Pan;Jacobson, Kristen C
- 通讯作者:Jacobson, Kristen C
Child psychopathic traits moderate relationships between parental affect and child aggression.
儿童精神病特征调节父母情感和儿童攻击性之间的关系。
- DOI:
- 发表时间:2011-10
- 期刊:
- 影响因子:13.3
- 作者:Yeh MT;Chen P;Raine A;Baker LA;Jacobson KC
- 通讯作者:Jacobson KC
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
KRISTEN C. JACOBSON其他文献
KRISTEN C. JACOBSON的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('KRISTEN C. JACOBSON', 18)}}的其他基金
Assessing a Structured, Goal-Oriented, Animal-Assisted Therapy Program among Youth with Socioemotional Problems: A Pilot Study of Feasibility, Acceptability, and Initial Efficacy
评估有社会情感问题的青少年的结构化、目标导向、动物辅助治疗计划:可行性、可接受性和初步疗效的试点研究
- 批准号:
10705738 - 财政年份:2022
- 资助金额:
$ 230.25万 - 项目类别:
Assessing a Structured, Goal-Oriented, Animal-Assisted Therapy Program among Youth with Socioemotional Problems: A Pilot Study of Feasibility, Acceptability, and Initial Efficacy
评估有社会情感问题的青少年的结构化、目标导向、动物辅助治疗计划:可行性、可接受性和初步疗效的试点研究
- 批准号:
10533210 - 财政年份:2022
- 资助金额:
$ 230.25万 - 项目类别:
Long-term benefits of dog ownership: Effects on stress and social behavior
养狗的长期好处:对压力和社会行为的影响
- 批准号:
8401129 - 财政年份:2012
- 资助金额:
$ 230.25万 - 项目类别:
Long-term benefits of dog ownership: Effects on stress and social behavior
养狗的长期好处:对压力和社会行为的影响
- 批准号:
8207421 - 财政年份:2012
- 资助金额:
$ 230.25万 - 项目类别:
They Call it Puppy Love: Epidemiology and Biology of the Child-Dog Bond
他们称之为早恋:童狗关系的流行病学和生物学
- 批准号:
7992875 - 财政年份:2010
- 资助金额:
$ 230.25万 - 项目类别:
They Call it Puppy Love: Epidemiology and Biology of the Child-Dog Bond
他们称之为早恋:童狗关系的流行病学和生物学
- 批准号:
8101166 - 财政年份:2010
- 资助金额:
$ 230.25万 - 项目类别:
Genetics of Vulnerability to Antisocial Behavior
反社会行为脆弱性的遗传学
- 批准号:
7168652 - 财政年份:2003
- 资助金额:
$ 230.25万 - 项目类别:
Genetics of Vulnerability to Antisocial Behavior
反社会行为脆弱性的遗传学
- 批准号:
6801006 - 财政年份:2003
- 资助金额:
$ 230.25万 - 项目类别:
Genetics of Vulnerability to Antisocial Behavior
反社会行为脆弱性的遗传学
- 批准号:
6673867 - 财政年份:2003
- 资助金额:
$ 230.25万 - 项目类别:
相似国自然基金
“抗疫精神”对医护职业偏好、行为偏好的短期与长期影响:基于医务人员和医学院学生的研究
- 批准号:72173093
- 批准年份:2021
- 资助金额:48 万元
- 项目类别:面上项目
湖州师范学院理论物理强子共振态和核物理方向学术交流与平台建设
- 批准号:
- 批准年份:2021
- 资助金额:50 万元
- 项目类别:
湖州师范学院理论物理奇特核结构与反应方向学术交流与平台建设
- 批准号:
- 批准年份:2020
- 资助金额:50 万元
- 项目类别:专项基金项目
数学院士专家大学中学系列科普活动
- 批准号:12026425
- 批准年份:2020
- 资助金额:20.0 万元
- 项目类别:数学天元基金项目
湖州师范学院基于HIRFL-CSR和HIAF的核物理理论发展和交流平台
- 批准号:
- 批准年份:2019
- 资助金额:50 万元
- 项目类别:专项基金项目
相似海外基金
Investigating Sleep-Related Disparities in U.S. Childrens Learning Difficulties
调查美国儿童学习困难中与睡眠相关的差异
- 批准号:
10191086 - 财政年份:2021
- 资助金额:
$ 230.25万 - 项目类别:
Investigating Sleep-Related Disparities in U.S. Childrens Learning Difficulties
调查美国儿童学习困难中与睡眠相关的差异
- 批准号:
10383729 - 财政年份:2021
- 资助金额:
$ 230.25万 - 项目类别:
Florida International University MARC U*STAR Program
佛罗里达国际大学 MARC U*STAR 项目
- 批准号:
7426578 - 财政年份:2008
- 资助金额:
$ 230.25万 - 项目类别:
Addiction Research and Investigation for Science Educators (ARISE)
科学教育者成瘾研究和调查(ARISE)
- 批准号:
7849006 - 财政年份:2008
- 资助金额:
$ 230.25万 - 项目类别:
Addiction Research and Investigation for Science Educators (ARISE)
科学教育者成瘾研究和调查(ARISE)
- 批准号:
7300966 - 财政年份:2008
- 资助金额:
$ 230.25万 - 项目类别: