Non-invasive characterization of secondary brain injuries after severe acute brain injury using integrated functional optical imaging and electroencephalography

使用集成功能光学成像和脑电图对严重急性脑损伤后继发性脑损伤进行非侵入性表征

• 批准号: 10198065
• 负责人: Ulas Sunar
• 金额: $ 7.94万
• 依托单位: WRIGHT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10198065
• 关键词: Acute; Acute Brain Injuries; Address; Blood flow; Brain; Brain Injuries; Brain region; Caring; Cerebrovascular Circulation; Cerebrum; Clinical; Color; Computer software; Custom; Device or Instrument Development; Devices; Diffuse; Diffusion; Electroencephalogram; Electroencephalography; Enrollment; FDA approved; Feedback; Goals; Gold; Human; Hypoxia; Injury; Intensive Care Units; Intervention; Investigation; Ischemia; Ischemic Stroke; Lead; Location; Measurement; Measures; Medicine; Metabolic; Monitor; Optics; Outcome; Oxygen; Patients; Physiologic pulse; Pilot Projects; Populations at Risk; Public Health; Records; Reporting; Scalp structure; Secondary to; Seizures; Severities; Signal Transduction; Site; Spectrum Analysis; Subarachnoid Hemorrhage; Survivors; System; TBI Patients; Technology; Testing; Time; Tissues; Traumatic Brain Injury; Trephine hole; base; brain electrical activity; brain tissue; cerebral oxygenation; computerized data processing; cost; data acquisition; data fusion; effective therapy; electric field; hemodynamics; high risk; imaging approach; improved; injury-related death; instrument; instrumentation; interest; light intensity; monitoring device; multidisciplinary; multimodality; optical imaging; programs; temporal measurement; tissue oxygenation; tool; validation studies

PROJECT SUMMARY/ABSTRACT There is a need for improved monitoring tools for the brain in TBI patients. Survivors of severe brain injuries may require care in an intensive care unit (ICU), where the brain is vulnerable to secondary brain injuries, defined by a mismatch between the metabolic supply and demand that creates ischemia. Existing technologies for monitoring secondary brain injuries are inadequate: continuous scalp EEG is noninvasive and detects seizures, but only indirectly reflects cerebral blood flow compromise. In some cases, invasive probes are placed within the brain to detect cerebral blood flow and brain tissue oxygenation directly. However, this strategy can be risky and only monitors a small region of the brain. Thus, there is a need for real-time, noninvasive, multimodal measurements of the brain’s electrical activity, oxygenation, and hemodynamics in humans. Our goal is to address this need through combined measurements of EEG and functional optical spectroscopy (EEG-Optical) instrumentation and analysis to provide a complementary fusion of data on brain activity and function. EEG records the brain’s local electrical field potentials with exquisite temporal resolution. Optical imaging uses low- intensity light to quantify cerebral blood flow (CBF) and cerebral oxygen saturation (StO2). In Aim 1, we will adapt our DCS current instrument for continuous for longitudinal monitoring of TBI patients alongside to clinical instruments. In Aim2, we will perform a validation study to evaluate this new, integrated, noninvasive technology by comparing directly with the gold standard, FDA-approved invasive measurement of brain blood flow and oxygenation in patients with TBI undergoing clinically-standard invasive monitoring. This study will lead directly to further device development and investigational device application, with a goal for a device that will allow for brain blood flow and oxygenation monitoring in all patients with acute brain injuries in order to guide management.

项目概要/摘要 严重脑损伤幸存者可能需要改进的大脑监测工具。 需要在重症监护室 (ICU) 接受护理，那里的大脑很容易受到继发性脑损伤，定义为 现有技术的代谢供应需求之间的不匹配会导致缺血。 监测继发性脑损伤是不够的：连续头皮脑电图是无创的，可以检测癫痫发作， 但仅间接反映脑血流受损。在某些情况下，侵入性探头被放置在脑内。 然而，这种策略可能存在风险且存在风险。 仅监测大脑的一小部分区域，因此需要实时、无创、多模式。 我们的目标是测量人类大脑的电活动、氧合和血流动力学。 通过脑电图和功能光谱（EEG-光学）的组合测量来满足这一需求 仪器和分析提供脑电图数据的补充融合。 以精细的时间分辨率记录大脑的局部电场电位。 在目标 1 中，我们将采用强度光来量化脑血流量 (CBF) 和脑氧饱和度 (StO2)。 我们的 DCS 当前仪器用于对 TBI 患者进行连续纵向监测以及临床 在 Aim2 中，我们将进行验证研究来评估这种新的、集成的、非侵入性技术。 通过直接与 FDA 批准的侵入性脑血流量测量金标准进行比较 这项研究将直接引导接受临床标准侵入性监测的 TBI 患者的氧合。 进一步的设备开发和研究设备应用，目标是开发一种能够允许 对所有急性脑损伤患者进行脑血流和氧合监测，以指导 管理。

项目成果

First-in-clinical application of a time-gated diffuse correlation spectroscopy system at 1064 nm using superconducting nanowire single photon detectors in a neuro intensive care unit.

使用超导纳米线单光子探测器在神经重症监护病房中首次临床应用 1064 nm 的时间选通漫相关光谱系统。

• DOI: 10.1364/boe.448135
• 发表时间: 2022-01-28
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: C. Poon;D. S. Langri;B. Rinehart;T. Rambo;A. Miller;B. Foreman;U. Sunar
• 通讯作者: U. Sunar

Non-Invasive Continuous Optical Monitoring of Cerebral Blood Flow after Traumatic Brain Injury in Mice Using Fiber Camera-Based Speckle Contrast Optical Spectroscopy.

使用基于光纤相机的散斑对比光学光谱法对小鼠脑外伤后的脑血流进行无创连续光学监测。

• 发表时间: 2023-09-25
• 影响因子: 3.3
• 作者: Langri, Dharminder S;Sunar, Ulas
• 通讯作者: Sunar, Ulas

Noninvasive Optical Monitoring of Cerebral Blood Flow and EEG Spectral Responses after Severe Traumatic Brain Injury: A Case Report.

严重创伤性脑损伤后脑血流和脑电图光谱反应的无创光学监测：病例报告。

• 发表时间: 2021-08-20
• 影响因子: 3.3
• 作者: Poon, Chien;Rinehart, Benjamin;Langri, Dharminder S;Rambo, Timothy M;Miller, Aaron J;Foreman, Brandon;Sunar, Ulas
• 通讯作者: Sunar, Ulas