Mentored career development in clinical research in non-malignant hematology

指导非恶性血液学临床研究的职业发展

• 批准号: 7916483
• 负责人: CHARLES S. ABRAMS
• 金额: $ 39.63万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-28 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7916483
• 关键词: Adult; Area; Basic Science; Benign; Biomedical Research; Biometry; Cellular biology; Childhood; Clinical; Clinical Research; Clinical Trials Design; Education; Educational Curriculum; Ensure; Environment; Epidemiology; Erythrocytes; Ethical Issues; Exposure to; Faculty; Funding; Future; Goals; Grant; Hematologist; Hematology; Hemostatic function; Immune System Diseases; Institutes; Knowledge; Lead; Medicine; Mentors; Methodology; Molecular; Myeloproliferative disease; Non-Malignant; Pediatric Hospitals; Pennsylvania; Philadelphia; Research; Research Methodology; Research Personnel; Resources; Stem cells; Structure; Therapeutic; TimeLine; Training; Transfusion; Translational Research; United States National Institutes of Health; Universities; Writing; base; career development; experience; meetings; member; next generation; programs; responsible research conduct; role model; tool; translational medicine

DESCRIPTION (provided by applicant): This application describes plans at the University of Pennsylvania and Children's Hospital of Philadelphia to train the next generation of leaders in clinical and translational research in non-malignant hematology. The breadth and depth of the hematology programs, along with additional resources at the University, provide an ideal setting for this career development program, which will be structured to cover four areas including: Hemostasis, Red Cell Disorders, Immune Hematology and Transfusion Medicine, and Stem Cells and Myeloproliferative Disorders. Experienced faculty members will lead each area and aid the Director and Co- Directors in developing a comprehensive curriculum in benign hematology. These faculty will serve as Primary Mentors, and with Secondary Mentors, will train scholars in their areas of expertise. In addtion, the program will utilize the resources within the recently developed Institute for Translational Medicine and Therapeutics. The specific training goals of this program are: 1) To provide broad-based clinical training and exposure to all aspects of pediatric and adult non-malignant hematology; 2) To guide the Scholar in acquiring the knowledge and tools necessary to be a successful clinical or translational researcher, including training in biostatistics, epidemiology, clinical trials design, and in the responsible conduct of research; 3) To develop scholars with a thorough understanding of advances in basic molecular and cell biology relevant to their areas of clinical research focus, and in methodologies used in these areas; 4) To ensure knowledge and understanding of ethical issues in both basic and clinical biomedical research; and, 5) To provide close mentoring of the scholars with defined timelines to meet goals in education, research, and scientific and grant writing, and to provide positive clinical research role models in a supportive academic environment. The program will train future clinical and translational researchers in benign hematology who are equipped with a sophisticated background in basic science and clinical research methodologies. It is anticipated that graduates of this program will be at the leading edge of their research field and ideally situated to compete for further NIH funding and to serve as faculty members in non-malignant hematology in academic centers, training the next generation of non-malignant hematologists.

描述（由申请人提供）： 该申请描述了宾夕法尼亚大学和费城儿童医院的计划，以培训非恶性血液学临床和转化研究领导者的下一代领导者。血液学计划的广度和深度以及大学的额外资源为这项职业发展计划提供了理想的环境，该计划将结构涵盖四个领域，包括：止血，红细胞疾病，免疫血液学和输血医学，以及干细胞以及干细胞和骨髓增生性疾病。经验丰富的教职员工将领导每个领域，并协助主任和联合主任在良性血液学中开发全面的课程。这些教师将担任主要导师，并在二级导师中培训其专业领域的学者。另外，该计划将利用最近开发的翻译医学和治疗学研究所中的资源。该计划的具体培训目标是：1）提供基于广泛的临床培训并暴露于儿科和成人非恶性血液学的各个方面； 2）指导学者获得成功的临床或转化研究人员所必需的知识和工具，包括在生物统计学，流行病学，临床试验设计方面的培训以及负责任的研究行为； 3）开发学者，对与临床研究重点以及这些领域使用的方法相关的基本分子和细胞生物学的进步有透彻的了解； 4）确保在基础和临床生物医学研究中了解和理解道德问题；以及5）为学者提供定义的时间表的密切指导，以满足教育，研究和科学授予写作的目标，并在支持性的学术环境中提供积极的临床研究榜样。该计划将培训良性血液学的未来临床和转化研究人员，他们配备了基础科学和临床研究方法的精致背景。可以预料，该计划的毕业生将位于其研究领域的前沿，理想地旨在竞争进一步的NIH资金，并担任学术中心非恶性血液学的教职员工，培训下一代非恶性血液学家。