Neuromarkers of Social Coordination: A Dynamical Approach

社会协调的神经标志物：动态方法

• 批准号: 7648151
• 负责人: J A SCOTT KELSO
• 金额: $ 34.78万
• 依托单位: FLORIDA ATLANTIC UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7648151
• 关键词: Address; Adult; Alzheimer' s Disease; Architecture; Area; Autistic Disorder; Awareness; Behavior; Behavioral; Biological Models; Brain; Brain region; Build-it; Clinical; Cognitive; Communication; Complex; Conscious; Coupled; Coupling; Development; Disease; Effectiveness; Electrodes; Electroencephalography; Experimental Models; Functional Magnetic Resonance Imaging; Goals; Heart; Housing; Human; Human Characteristics; Individual; Laboratories; Link; Measures; Mediating; Mental Health; Methods; Mission; Motor; National Institute of Mental Health; Nature; Neurons; Neurosciences; Perception; Physics; Process; Psychology; Reproducibility; Research; Research Personnel; Rest; Schizophrenia; Social Behavior; Social Environment; Social Functioning; Social Interaction; Social support; Stimulus; Systems Analysis; Time; Work; addiction; base; cognitive neuroscience; computerized data processing; density; depression; enhancing factor; member; neural patterning; neurobehavioral; neurobiological mechanism; neuromechanism; neurophysiology; neuropsychiatry; novel; relating to nervous system; research study; response; social; social neuroscience; stability testing; success

DESCRIPTION (provided by applicant): This application addresses a fundamental question of significance to understanding human nature and the entire field of social neuroscience: "What distinguishes a true social interaction between human beings from other perceptuo-motor interactions?" Understanding how coordination occurs both within the human brain and between human brains is vital to the basic and clinical neuroscience mission of NIMH, The reason is that disruptions of coordinative interactions among cortical and subcortical areas and the breakdown of neural integration are thought to lie at the heart of major neuropsychiatric disorders such as schizophrenia and autism. We aim to 1) identify the neurobehavioral mechanisms underlying how brain regions couple and decouple both within an individual brain and between brains engaged in social settings and 2) clarify the nature of the informational coupling between individuals engaged in social behavioral interactions. The work will be carried out by a dedicated interdisciplinary team of researchers whose expertise spans cognitive neuroscience, psychology and physics. It builds upon and explores in depth our recent discovery of an oscillatory complex in the brain that may act as a specific neuromarker of social behavior. The proposed research uses behavioral methods and sophisticated computational analyses in combination with dual high density EEG electrode arrays developed for the simultaneous recording of brain activity from interacting pairs of people to uncover where social signals are processed in the brain and how they become coupled dynamically between individuals. The novel conceptual and analytic framework of coordination dynamics is used to explore cognitive (within brain) and social (shared between-brain) neural representations hypothesized to underlie social coordination. Coordination dynamics provides theoretical concepts, methods and ecologically valid paradigms to attack the outstanding question of how large scale integration in the brain and across brains is accomplished. The research represents a first attempt to incorporate dynamical systems analysis into the study of socially-mediated neurophysiological activity in conscious, interacting humans. Uncovering the neurobiological mechanisms that underlie coordinated human behavior in an individual during social interactions constitutes a major step toward understanding neuropsychiatric disorders and is likely to result in the development of more effective pharmacological and behaviorally relevant treatments.

描述（由申请人提供）：本申请解决了理解人性和整个社会神经科学领域的重要问题：“是什么区别了人类与其他感知运动互动之间的真正社会互动？”了解协调如何在人脑内和人的大脑之间进行，对于NIMH的基本和临床神经科学任务至关重要，原因是，皮质和皮层区域之间协调性相互作用的破坏以及神经整合的崩溃被认为是主要神经性精神疾病的核心和诸如Schizizophrenia和自动化之类的主要神经性疾病的核心。我们的目的是1）确定大脑区域如何在个体大脑内以及从事社交环境的大脑之间的夫妻和将大脑之间的夫妇融合在一起的神经行为机制； 2）阐明参与社交行为互动的个人之间信息耦合的性质。这项工作将由专门的研究人员跨学科团队进行，其专业知识涵盖了认知神经科学，心理学和物理学。它基于并深入探索了我们最近发现的大脑中一种振荡复合物，该复合物可能是社会行为的特定神经标志物。拟议的研究使用了行为方法和复杂的计算分析，结合了双重高密度的EEG电极阵列，用于同时记录大脑活动，从相互作用的人们到揭露在大脑中处理社会信号以及如何在个人之间动态耦合的社会信号。协调动力学的新颖概念和分析框架用于探索认知（大脑）和社会（脑之间共享）神经表示，假设是社会协调的基础。协调动力学提供了理论概念，方法和生态有效的范式，以攻击大脑和整个大脑中大规模整合的杰出问题。这项研究是将动态系统分析纳入有意识，相互作用的人类中社会介导的神经生理活性的研究的首次尝试。在社交互动过程中揭示了人类行为的基础的神经生物学机制构成了理解神经精神疾病的主要步骤，并且很可能导致发展更有效的药理和行为相关的治疗方法。