Neural Mechanisms of MTBI: A Prospective fMRI Approach

MTBI 的神经机制：一种前瞻性的功能磁共振成像方法

• 批准号: 6993626
• 负责人: J A SCOTT KELSO
• 金额: $ 31.07万
• 依托单位: FLORIDA ATLANTIC UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-15 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6993626
• 关键词: Internet; behavior disorders; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain injury; brain morphology; clinical research; cognition; computer program /software; functional ability; functional magnetic resonance imaging; human subject; male; neural plasticity; neuropsychological tests; patient oriented research; rehabilitation; sports injury

DESCRIPTION (provided by applicant): Although several mechanisms have been proposed to underlie observed neuropsychological deficits and subsequent recovery of function following Mild Traumatic Brain Injury (MTBI), to date the link between alterations in axonal morphology, large scale neural functioning and behavioral recovery has not been established. This proposal represents an integrated approach to establishing a connection between structural damage resulting from MTBI, consequent deficits in neural functioning and the outward manifestations of cognitive and behavioral symptoms. The approach is both discovery-based and hypothesis driven, in which animal models of neural reorganization and regeneration, as well as possible cognitive compensatory processes are subject to empirical test. The accessibility to pre-injury baseline measures in athletes makes concussion an ideal entry point into the prospective study of MTBI and recovery of function. Over five consecutive years, pre-season baseline measures will be collected from FAU football players (N=80/year) on a Comprehensive Imaging Protocol for the Assessment of Concussion (CIPAC). The CIPAC will employ a combination of: a) functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), b) a Web-based neurocognitive assessment battery designed specifically for prospective testing (Concussion Resolution Index, Headminder Inc.), c) the NeuroCom(R) sensory organization test and d) self reported symptoms. Players identified as suffering a concussion during the course of the season will enter a post-concussion recording schedule in which they will be tested within 24 hours following injury and at regular intervals during recovery and during follow-up at 1 and 3 months. In this prospective approach, pre-injury levels of behavioral and neural functioning acquired during baseline testing will be used to evaluate post-concussion deficits independently for each individual. Particular focus will be on questions concerning: 1) the morphological, physiological and behavioral consequences of (multiple) concussions; 2) mechanisms of plasticity and recovery of function following MTBI; 3) the relationship between deficits in neural functioning and standardized behavioral measures of concussion; and 4) the implications for current assessment techniques and return to play guidelines. This individualized approach should provide important insights into the structural and dynamic mechanisms underlying recovery of function in the human brain.

描述（由申请人提供）：虽然已经提出了几种机制来解释观察到的神经心理缺陷和随后的轻度创伤性脑损伤（MTBI）后的功能恢复，但迄今为止，轴突形态的改变、大规模神经功能和行为恢复之间的联系尚未确定。尚未成立。该提案代表了一种综合方法，用于在 MTBI 造成的结构损伤、随之而来的神经功能缺陷以及认知和行为症状的外在表现之间建立联系。该方法既基于发现又由假设驱动，其中神经重组和再生的动物模型以及可能的认知补偿过程都受到实证检验。运动员受伤前基线测量的可及性使得脑震荡成为 MTBI 和功能恢复前瞻性研究的理想切入点。连续五年，将根据脑震荡评估综合成像方案 (CIPAC) 从 FAU 足球运动员（N=80/年）收集季前基线测量数据。 CIPAC 将采用以下组合：a) 功能磁共振成像 (fMRI) 和扩散张量成像 (DTI)，b) 专门为前瞻性测试设计的基于网络的神经认知评估组（脑震荡分辨率指数，Headminder Inc.），c ) NeuroCom(R) 感觉组织测试和 d) 自我报告的症状。在赛季期间被确定患有脑震荡的球员将进入脑震荡后记录时间表，其中他们将在受伤后 24 小时内接受测试，并在康复期间以及 1 个月和 3 个月的随访期间定期接受测试。在这种前瞻性方法中，在基线测试期间获得的受伤前行为和神经功能水平将用于独立评估每个人的脑震荡后缺陷。特别关注以下问题： 1) （多次）脑震荡的形态、生理和行为后果； 2）MTBI后的可塑性和功能恢复机制； 3）神经功能缺陷与脑震荡标准化行为测量之间的关系； 4) 对当前评估技术和重返比赛指南的影响。这种个性化的方法应该为人脑功能恢复的结构和动态机制提供重要的见解。