HRT AND EXERCISE EFFECTS ON CENTRAL ARTERIAL COMPLIANCE

激素替代疗法和运动对中央动脉顺应性的影响

• 批准号: 7604454
• 负责人: Kerrie Moreau
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604454
• 关键词: Arteries; Carotid Arteries; Computer Retrieval of Information on Scientific Projects Database; Conjugated Estrogens; Estradiol; Estrogens; Exercise; Funding; Grant; Heart; Home environment; Hormone replacement therapy; Institution; Measures; Menopause; Neck; Nervous system structure; Oral; Outcome Study; Pharmaceutical Preparations; Placebos; Postmenopause; Protocols documentation; Randomized; Research; Research Personnel; Resources; Source; Ultrasonography; United States National Institutes of Health; Walking; Week; Woman; base; cardiovascular disorder risk; day; heart disease risk; improved; improved functioning; programs; protective effect

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Increases in the stiffness of arteries located throughout the body are associated with a higher risk for heart disease. After menopause, women have a higher risk for cardiovascular disease possibly due to the loss of estrogen. The increased risk for cardiovascular disease may be due, in part, to the increase in the stiffness of the arteries. Hormone replacement therapy (HRT) and regular exercise have been shown to be associated with a lower risk for cardiovascular disease, and may be producing their protective effects through favorable effects on the walls of the artery. The proposed protocol will determine the effects of three different types of HRT and the combined effects of HRT and exercise on improving the stiffness of arteries located in your neck (carotid), as well as on improving the function of your heart and nervous system. Postmenopausal women will be randomly assigned to one of four groups: conjugated estrogen, oral estradiol, estrogen patch, or placebo (no medication). After 3 months, the women will be placed on a home-based endurance-exercise program consisting moderate intensity walking for 40-45 minutes a day, 5-7 days per week. The women will continue to take their HRT while participating in the 3 month walking program. Ultrasound images of the carotid artery and heart will be measured at the beginning of the study and after 6 months of the therapy. The primary outcome of the study will be to determine whether women taking HRT and/or exercise demonstrate an improvement in the stiffness or their arteries.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 整个体内的动脉刚度的增加与心脏病的风险更高有关。 更年期后，女性患心血管疾病的风险较高，可能是由于雌激素的丧失。 心血管疾病的风险增加可能部分是由于动脉僵硬度的增加。 激素替代疗法（HRT）和定期运动已被证明与患心血管疾病的风险较低有关，并且可能通过对动脉壁的有利作用产生保护作用。 提出的方案将确定三种不同类型的HRT的影响以及HRT和运动对改善颈部动脉僵硬（颈动脉）的僵硬以及改善心脏和神经系统功能的影响。绝经后妇女将随机分配给四组之一：共轭雌激素，口服雌二醇，雌激素斑块或安慰剂（无药物）。 3个月后，这些妇女将被置于一个家庭耐力运动计划中，每周5-7天，每天5-7天，每天40-45分钟的步行时间。 妇女将在参加3个月的步行计划时继续接受HRT。 颈动脉和心脏的超声图像将在研究开始和治疗6个月后测量。 该研究的主要结果是确定服用HRT和/或运动的妇女是否表现出僵硬或动脉的改善。