SEX, AGING, AND VARIATION IN VASCULAR FUNCTIONALITY SAVVY

性别、衰老和血管功能变化

• 批准号: 8167039
• 负责人: CHERYL D BUSHNELL
• 金额: $ 4.5万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167039
• 关键词: Acceleration; Aging; Atherosclerosis; Atrial Fibrillation; Biological Markers; Blood Pressure; Blood Vessels; Carotid Arteries; Cause of Death; Climacteric; Computer Retrieval of Information on Scientific Projects Database; Coronary heart disease; Disease; Estrogens; Funding; Grant; Hypertension; Incidence; Institution; Investigation; Knowledge; Lead; Lipids; Measures; Menopause; Peripheral Vascular Diseases; Prevention strategy; Research; Research Personnel; Resources; Risk; Risk Factors; Sex Characteristics; Source; Stroke; Time; Tobacco smoking; United States National Institutes of Health; Variant; Vascular Diseases; Weight Gain; Woman; disability; fasting glucose; men; middle age; sex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Stroke is the third leading cause of death in the U.S. and the leading cause of disability. More women than men die from stroke, although men have a higher incidence of stroke. There many other gender differences that are becoming recognized as important, as well, such as risk profiles. For example, men with stroke are more likely to have coronary disease, peripheral vascular disease, and tobacco smoking, whereas, women are more likely to have atrial fibrillation and hypertension. Women also have acceleration of risk factors associated with menopause, which is believed to be related to endogenous estrogen depletion. During this time women frequently develop increased blood pressure and fasting glucose, an atherogenic lipid profile, weight gain, and progression of subclinical atherosclerosis in the carotid arteries. Therefore, in women, mid-life changes may significantly accelerate stroke risk, but many of these changes may be unrecognized because they are subclinical. In addition, various measures of subclinical vascular disease may differ depending on the presence of specific risk factors. Therefore, if only one vascular measure is performed, it may not adequately represent the impact of specific risk factors, and these effects may be sex-specific. In addition, prevention strategies are increasingly being studied with intermediate measures of vascular disease. Investigations of midlife subclinical vascular disease in men and women would aid in our understanding of the risk factors, and biomarkers that impact subclinical risk. This could then lead to sex-specific strategies of prevention earlier than would otherwise occur without knowledge of subclinical disease.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 中风是美国第三大死亡原因，也是残疾的主要原因。尽管男人的中风发生率更高，但女性多于男人死于中风。还有许多其他性别差异也被认为是风险概况等重要的。例如，患有中风的男性更有可能患有冠状动脉疾病，周围血管疾病和吸烟，而女性则更有可能患有心房颤动和高血压。妇女还具有与更年期相关的危险因素加速，这被认为与内源性雌激素耗尽有关。在此期间，妇女经常出现升高的血压和空腹葡萄糖，动脉粥样硬化的脂质特征，体重增加以及颈动脉中亚临床动脉粥样硬化的进展。因此，在妇女中，中年的变化可能会大大加速中风风险，但是其中许多变化可能无法识别，因为它们是亚临床的。此外，亚临床血管疾病的各种测量可能取决于特定危险因素的存在。因此，如果仅执行一种血管措施，则可能不能充分代表特定危险因素的影响，并且这些影响可能是特定于性别的。此外，通过血管疾病的中间措施，越来越多地研究了预防策略。对男性和女性中期亚临床血管疾病的调查将有助于我们对影响亚临床风险的危险因素以及生物标志物的理解。然后，这可能会导致预防性特定的预防策略，而不是在没有亚临床疾病的情况下发生的。