BIOLOGICAL MECHANISMS OF ARTERIAL STIFFENING WITH AGE AND ESTROGEN

年龄和雌激素导致动脉硬化的生物学机制

• 批准号: 7719538
• 负责人: Kerrie Moreau
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719538
• 关键词: Age; Arteries; Atherosclerosis; Biological; Cardiovascular Diseases; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Estrogens; Funding; Grant; Heart; High Blood Pressure; Institution; Lead; Menopause; Numbers; Oxidative Stress; Production; Purpose; Research; Research Personnel; Resources; Source; Tissues; United States National Institutes of Health; Woman; Work; cell injury; heart disease risk; loss of function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cardiovascular disease (CVD) is the number one killer in women. After menopause, women have a higher risk for heart disease possibly due to the loss of estrogen. One potential reason for this is that decreasing levels of estrogen have been shown to cause arteries surrounding the heart to stiffen . This stiffening of the arteries causes the heart to work harder and can lead to the development of high blood pressure and atherosclerosis. The purpose of this study is to find out how the loss of estrogen causes arteries to stiffen. One explanation that we will explore is the production of oxidative stress which are molecules that can damage cells and tissues in the body. Another explanation that we will explore is the loss of functioning of the arteries to dilate. We hope that these preliminary data will be able to help our understanding as to how the loss of estrogen as women go through menopause may contribute to the development of CVD.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 心血管疾病（CVD）是女性中排名第一的杀手。 更年期后，女性患心脏病的风险可能更高，可能是由于雌激素的丧失。 造成这种情况的一个潜在原因是，雌激素水平的降低已被证明会导致心脏周围的动脉变硬。 这种动脉的僵硬会导致心脏更加努力，并可能导致高血压和动脉粥样硬化的发展。 这项研究的目的是找出雌激素的丧失如何导致动脉变硬。 我们将要探索的一种解释是产生氧化应激，即氧化应激，这是可以损害体内细胞和组织的分子。 我们将探讨的另一个解释是动脉扩张的功能丧失。 我们希望这些初步数据能够帮助我们了解雌激素随着更年期的经历如何促进CVD的发展。