Research Experience and Training Coordination Core

研究经验和培训协调核心

• 批准号: 10353540
• 负责人: Jamie J Bernard
• 金额: $ 7.68万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10353540
• 关键词: Atmosphere; Biochemistry; Biological Sciences; Biology; Collaborations; Communication; Communities; Computational Biology; Data; Data Analyses; Dimensions; Discipline; E-learning; Educational process of instructing; Engineering; Environmental Health; Environmental Pollution; Faculty; Genomics; Health; Historically Black Colleges and Universities; Hour; Individual; Informatics; Information Systems; Institutes; Instruction; Interdisciplinary Study; Joints; Journals; Laboratories; Learning; Link; Mathematics; Methods; Michigan; Modeling; Molecular Biology; Motivation; Movement; National Institute of Environmental Health Sciences; Pharmacology; Physiological; Postdoctoral Fellow; Procedures; Publications; Research; Research Personnel; Research Project Grants; Risk; Rivers; Running; Science; Series; Signal Recognition Particle; Social Sciences; Soil; Students; Superfund; System; Systems Biology; Techniques; Thinking; Time; Toxicokinetics; Toxicology; Training; Translational Research; Travel; Uncertainty; Underrepresented Minority; United States National Institutes of Health; Universities; Videoconferencing; Visit; aryl hydrocarbon receptor ligand; base; community based participatory research; community engagement; course introduction; data management; design; doctoral student; educational atmosphere; experience; graduate student; informal learning; innovation; insight; meetings; member; microbial; outreach; pandemic coronavirus; paragon; pharmacokinetic model; physical science; pre-doctoral; recruit; response; risk perception; social; student training; success; undergraduate research experience; virtual; virtual laboratory

The overarching theme of the Michigan State University Superfund Research Center (MSU SRC) is to understand environmental, microbial and mammalian biomolecular responses to environmental contaminants that act as ligands for the aryl hydrocarbon receptor (AhR). The Research Experience and Training Coordination Core (RETCC) aims to enhance the Center’s success by promoting collaborative, interdisciplinary research. Disciplines represented include: Biochemistry, Computational Biology, Engineering, Data Management & Analysis, Mol. Biology, Pharmacology, Soil Science, Social Science and Toxicology providing trainees with integrated opportunities to value and seek new perspectives. Cross-training of students will be achieved through a multifaceted training approach involving laboratory-based research plus formal and informal instruction. This is designed to accelerate movement towards “Convergence” the third revolution in the biological sciences (molecular biology being the 1st and genomics the 2nd) (Sharp et al., 2011) by bringing the biological sciences, physical sciences/engineering and mathematics together. The MSU SRC is a paragon of this movement, as evidenced by the collaborations leading to joint publications by the toxicologists, engineers and mathematical modelers involved in the Project. Interdisciplinary research is accomplished by promoting nine Specific Aims: (1) Monthly Virtual Laboratory meetings where the Michigan State, Emory, Purdue and Rutgers researchers link by video conferencing, with emphasis placed on presentations by graduate students and post-doctoral fellows; (2) a four-session interactive Seminar Series providing a conceptual and motivational framework for trainees to appreciate the value of embracing multi-method, interdisciplinary research involving teams of diverse individuals; (3) Diverse trainee recruitment and retention; (4) providing interdisciplinary training to students through (i) formal instruction (a Computational Biology course, and a Physiologically-based Toxicokinetics course– both presented as intensive three and five day hands-on short courses), (ii) a seminar series organized by the graduate student/postdoctoral fellows who invite the speakers, and (iii) support travel to provide special educational opportunities, visit a lab to learn a new technique; (5) a Systems Biology/Genomics Journal Club; (6) a one semester course meeting 1 hour/week, focused on the social dimensions and communication of environmental health research; (7) to provide basic introduction to data management and analysis; (8) to provide information about the Center’s activities and trainees to the SRP on a quarterly basis; and (9) to institute procedures for compliance with the requirement that all graduate students and post docs enter their relevant information in NIH’s CareerTrac in a timely fashion. This package of activities serves as an innovating and coordinating hub to bring together all involved in the SRC. If the coronavirus pandemic continues, the non-laboratory portions of these aims will be accomplished in digital learning environments. We anticipate 20 PhD students and 5 PostDocs in the MSU SRC/year and their training period will be approximately 4.5-5 and 2-3 years, respectively.

密歇根州立大学超级基金研究中心 (MSU SRC) 的首要主题是 了解环境、微生物和哺乳动物生物分子对环境污染物的反应 作为芳基烃受体 (AhR) 的配体 研究经验和培训协调。 核心（RETCC）旨在通过促进协作、跨学科研究来提高中心的成功。 代表学科包括：生物化学、计算生物学、工程学、数据管理和 分析、分子生物学、药理学、土壤科学、社会科学和毒理学为学员提供 通过交叉培训，可以实现学生重视和寻求新观点的综合机会。 多方面的培训方法，包括基于实验室的研究以及正式和非正式的指导。 旨在加速生物科学第三次革命“融合”的发展 （分子生物学是第一个，基因组学是第二个）（Sharp et al., 2011）通过引入生物科学， 密歇根州立大学 SRC 是这一运动的典范，因为它融合了物理科学/工程和数学。 毒理学家、工程师和数学家的合作导致联合出版物证明了这一点 参与该项目的建模者通过促进九个具体目标来实现：(1) 每月一次的虚拟实验室会议，密歇根州立大学、埃默里大学、普渡大学和罗格斯大学的研究人员通过以下方式联系起来 视频会议，重点是研究生和博士后研究员的演讲（2）； 为期四节的互动研讨会系列，为学员提供概念和激励框架 认识到采用由不同个人参与的多方法、跨学科研究团队的价值； (3) 多样化的学员招募和保留； (4) 通过 (i) 正式培训为学生提供跨学科培训 教学（计算生物学课程和基于生理学的毒代动力学课程 - 均提供 (ii) 毕业生组织的系列研讨会 邀请演讲者的学生/博士后研究员，以及 (iii) 支持旅行以提供特殊教育 机会，参观实验室学习新技术；（5）系统生物学/基因组学期刊俱乐部；（6） 学期课程会议 1 小时/周，重点关注环境的社会维度和沟通 健康研究；（7）提供数据管理和分析的基本介绍；（8）提供信息； 每季度向 SRP 通报中心的活动和受训人员情况；以及 (9) 制定以下程序： 遵守所有研究生和博士后在 NIH 中输入相关信息的要求 CareerTrac 及时地提供了这一系列活动作为创新和协调中心。 如果冠状病毒大流行持续下去，所有参与 SRC 的人都将被排除在外。 我们预计将有 20 名博士生和 5 名博士后在数字化学习环境中实现。 MSU SRC/年和他们的培训时间分别约为 4.5-5 和 2-3 年。