2022 Lysosomes & Endocytosis Gordon Research Conference and Gordon Research Seminar

2022 溶酶体

基本信息

批准号：
10461542
负责人：
Christopher G Burd
金额：
$ 1.6万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10461542
关键词：
Academy Address Area Autophagocytosis Award Awareness Biochemistry Biological Models Biology Blood Coagulation Disorders Blood coagulation Cancer Model Cell Death Cells Cellular biology Clinical Collaborations Communication Communities Cytokinesis Data Defect Development Disabled Persons Disease Down-Regulation Drug Addiction Endocytosis Environment Fostering Funding Genetic Genetic Diseases Goals Growth Health Hemostatic function Hermanski-Pudlak Syndrome Homeostasis Human Immune Immune System Diseases Immunity Immunology Inflammation Institutes International Investments Knowledge Link Lysosomes Malignant Neoplasms Mammalian Cell Medicine Membrane Mentorship Metabolism Microbiology Mission Molecular National Center for Advancing Translational Sciences National Institute of Allergy and Infectious Disease National Institute of Child Health and Human Development National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Drug Abuse National Institute of Neurological Disorders and Stroke Nerve Degeneration Neurodegenerative Disorders Neurons Neurosciences Niemann-Pick Diseases Nobel Prize Nutrient Oral Organ Organelles Parkinson Disease Pathway interactions Patients Pharmacologic Substance Pharmacology Physiological Physiological Adaptation Physiology Pigmentation physiologic function Play Postdoctoral Fellow Property Recording of previous events Request for Applications Research Research Personnel Rodent Role Running Sampling Scientist Signal Pathway Signal Transduction Synaptic plasticity System Tissues Toxic effect Tuberous Sclerosis United States National Institutes of Health Variant Virus Diseases Woman Yeasts career cell injury cell type cytotoxicity detection of nutrient experience fly glucose metabolism graduate student human disease informal atmosphere interest lipid metabolism macromolecule meetings neuronal patterning pathogen posters prevent programs proteostasis receptor recycling skills success symposium

项目摘要

Abstract This application requests partial support for a Gordon Research Conference (GRC) on Lysosomes and Endocytosis at Proctor Academy, Andover, NH from June 19-24, 2022. Support for the associated Gordon Research Seminar (GRS) immediately preceding the GRC (June 18-19) is also requested. The Lysosomes and Endocytosis GRC has a 50+ year tradition as the preeminent scientific venue for investigators of endocytosis and lysosome biology in health and in disease. It is also highly regarded for the high level of communication between colleagues at all career levels, and for the mentorship of junior colleagues. For more than a decade now molecular mechanisms of endocytosis and for targeting of molecules to the lysosome for degradation have been the focus of this GRC. However, the field evolves rapidly, and recent advances indicate roles for the endo-lysosome and autophagy pathways in cancer, development, cytokinesis, intra- and inter- cellular signaling, immunity, metabolism, neurodegeneration and other neuronal diseases. The principal goal of the 2022 GRC is to build bridges between investigators working to elucidate molecular mechanisms and investigators of physiological aspects of the lysosome. A related goal is to raise awareness of and interest in lysosome biology outside of the field proper. Accordingly, the 2022 GRC program will embrace an exceptionally diverse cast of 28 invited speakers, favoring colleagues who have either not previously attended or presented at this GRC. Also featured are investigators who have not attended the conference for many years (e.g., >10 years) due to the evolving emphasis of their research programs on human disease; they provide a reservoir of experience regarding the application of fundamental knowledge of the endo-lysosome system to physiological questions. Areas to be addressed include the roles of the endo-lysosomal system in cancer, pathogen (including viruses) infection, nutrient sensing, the control of metabolism, and signaling between tissues. To attain the freshest program possible, nineteen speakers will be selected from submitted abstracts and one entire session will be devoted to new research directions. All attendees will be encouraged to participate in one of two poster sessions. A Gordon Research Seminar (GRS), open solely to graduate students and postdoctoral researchers, will convene one day prior to the start of the GRC. The informal atmosphere of the GRS allows trainees to build presentation and networking skills in a nurturing environment. Due to the vital importance of the endo-lysosomal system to human physiology, and the exceptional record of success of past Lysosomes and Endocytosis Gordon Research Conferences, the support of the NCI, NCATS, NIAID, NIA, NICHD, as well as other NIH institutes, will advance critical investments toward understanding lysosome biology in health and disease.

抽象的本申请请求对溶酶体和戈登研究会议 (GRC) 的部分支持 2022 年 6 月 19 日至 24 日在新罕布什尔州安多弗普罗克特学院进行内吞作用。对相关戈登的支持还要求在 GRC（6 月 18 日至 19 日）之前举行研究研讨会 (GRS)。溶酶体 GRC 拥有 50 多年的传统，是研究人员的卓越科学场所健康和疾病中的内吞作用和溶酶体生物学。也因其高水平而受到高度评价各个职业级别的同事之间的沟通，以及对初级同事的指导。了解更多十多年来，人们对内吞作用和将分子靶向溶酶体的分子机制进行了研究退化问题一直是本次 GRC 的重点。然而，该领域发展迅速，最近的进展表明内溶酶体和自噬途径在癌症、发育、胞质分裂、细胞内和细胞间的作用细胞信号传导、免疫、代谢、神经退行性疾病和其他神经元疾病。主要目标 2022 年 GRC 旨在在致力于阐明分子机制的研究人员和溶酶体生理方面的研究人员。一个相关的目标是提高人们的认识和兴趣溶酶体生物学在本领域之外。因此，2022 年 GRC 计划将包括 28 位受邀演讲者的阵容极其多元化，偏向以前未参加过会议的同事或在本 GRC 上提出。还介绍了很多年没有参加会议的调查人员年（例如，>10 年），因为他们的研究项目对人类疾病的重视程度不断变化；他们提供关于应用内溶酶体基础知识的经验库生理学问题的系统。要解决的领域包括内溶酶体系统在癌症、病原体（包括病毒）感染、营养传感、代谢控制和信号传导组织之间。为了获得尽可能最新的节目，将从提交的内容中选出 19 名演讲者摘要和一整个会议将致力于新的研究方向。所有与会者都将受到鼓励参加两个海报会议之一。戈登研究研讨会 (GRS)，仅向毕业生开放学生和博士后研究人员将在 GRC 开始前一天召开会议。非正式的 GRS 的氛围使学员能够在培育环境中培养演讲和社交技能。由于内溶酶体系统对人类生理学至关重要，以及过去溶酶体和内吞作用戈登研究会议的成功，NCI、NCATS 的支持， NIAID、NIA、NICHD 以及其他 NIH 机构将推进关键投资以促进理解健康和疾病中的溶酶体生物学。