Training in Translational Research and Entrepreneurship in Pulmonary Vascular Biology

肺血管生物学转化研究和创业培训

• 批准号: 9906249
• 负责人: Mark T Gladwin
• 金额: $ 55.03万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9906249
• 关键词: Biology; Blood Vessels; Entrepreneurship; Lung; Training; Translational Research; Biology; Blood Vessels; Entrepreneurship; Lung; Training; Translational Research

SUMMARY/ABSTRACT Biomedical investigators are experiencing a limitation in their collective ability to translate the remarkable basic science discoveries of the current era into the clinical arena—a divide appropriately termed “the valley of death.” In our first cycle of funding, we developed a novel training program in bench-to-bedside research methodology designed to train the next generation of clinical and basic researchers in translational approaches to pulmonary vascular biology and medicine. Our first eight trainees have had considerable success in publications, grant funding, and securing academic positions; two of the trainees were underrepresented minorities and six were women. In response to feedback from our current trainees and advisory boards, and in an effort to address the increasing pressure from the NIH, political leaders, and the public to translate basic discovery into therapeutic applications that positively change lives, we will extend the scope of our program in this second cycle of funding to incorporate entrepreneurial training, including: 1) development of a novel joint University of Pittsburgh (ranked #5 in NIH funding)-Carnegie Mellon University MBA Program (ranked #1 in part-time programs) in Entrepreneurship; 2) elective rotations focused on commercialization of biotechnology; and 3) an expanded faculty that includes translational scientist-entrepreneurs. We have created separate milestone-driven Translational Tracks and Entrepreneurial Tracks, but retaining the option for trainees to customize an Individual Development Plan to include components of either track. Trainees will be co-mentored by faculty with complementary research approaches to provide comprehensive training, and projects focused on patient-oriented bench-to-bedside (T1) research, with constant attention to trainee career development. Our faculty include translationally-focused pulmonologists, cardiologists, vascular surgeons, and PhDs spanning basic science to entrepreneurship, with a history of scientific productivity in pulmonary vascular biology, excellent funding support, successful mentoring, and expertise from drug discovery to commercialization of biotechnology. Substantial institutional support and resources are available through endowments to the VMI and a translational program project grant directed by Dr. Gladwin. The proposed training program, leadership, advisory boards, training faculty, and infrastructure at the University of Pittsburgh are strongly positioned to build on an already rich bench-to-bedside translational training program and create a generation of researchers committed to spanning the “valley of death” between basic research discoveries, clinical application, and commercial viability in pulmonary vascular disease.

摘要/摘要 生物医学研究人员正在遇到限制他们的集体能力，以翻译非凡的基本 当前时代的科学发现进入临床领域 - 适当地称为“ 死亡。 旨在培训下一代临床和基础研究人员的方法论 肺血管生物学和医学。我们的前八名学员已经考虑了成功 出版物，授予资金和确保学术职位；其中两个培训的人数不足 少数民族和六个是女性。为了回应我们目前的培训和咨询委员会的反馈，以及 努力应对NIH，政治领导人和公众的日益压力，以翻译基本 发现对改变生活的治疗应用程序，我们将扩展我们计划的范围 融合创业培训的第二个资金周期，包括：1）开发新的关节 匹兹堡大学（NIH资助中排名第5）-Carnegie Mellon University MBA课程（排名第一 兼职计划）企业家精神； 2）专注于生物技术商业化的选修课； 3）包括翻译的科学家 - 企业家在内的扩展教师。我们已经创建了单独的 里程碑驱动的翻译轨道和企业家轨道，但保留了培训的选择 自定义单个开发计划，以包括两个轨道的组件。学员将被共同授予 通过教师采用完整的研究方法来提供全面的培训，并以项目为重点 在面向患者的基准​​（T1）研究上，不断关注受训者的职业发展。我们的 教师包括翻译专注的肺科医生，心脏病学家，血管外科医生和PHDS跨度 企业家基础科学，具有肺血管生物学的科学生产力的史， 从药物发现到商业化的出色资金支持，成功的心理和专业知识 生物技术。可以通过VMI的捐赠提供大量的机构支持和资源 以及由Gladwin博士指导的翻译计划项目赠款。拟议的培训计划，领导力， 匹兹堡大学的咨询委员会，培训教职员工和基础设施很强 建立在已经很丰富的基准对床位的翻译培训计划的基础上，并创建了一代研究人员 致力于跨越基础研究发现，临床应用和 肺血管疾病的商业生存能力。