Mechanisms of signaling in otoconial organs

耳锥器官的信号传导机制

基本信息

批准号：
7534032
负责人：
ELLENGENE H PETERSON
金额：
$ 58.31万
依托单位：
OHIO UNIVERSITY ATHENS
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-07-01 至 2011-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7534032
关键词：
Address Animals Attention Auditory Award Behavior Biological Models Biomechanics Build-it Cell model Clinical Computing Methodologies Coupling Data Databases Diagnosis Elements Figs - dietary Foundations Frequencies Functional disorder Goals Hair Hair Cells Head Movements In Situ In Vitro Information Theory Knowledge Labyrinth Lead Learning Left Magnetic Resonance Imaging Measurement Measures Mechanics Medical Membrane Mission Modeling Movement National Institute on Deafness and Other Communication Disorders Organ Pattern Peripheral Physicians Posture Preparation Process Property Research Research Personnel Semicircular canal structure Shapes Signal Transduction Source Space Perception Speed Staging Stimulus Structure System Systems Analysis Testing Time Turtles Type I Hair Cell Utricle structure Video Recording Visit Work base cell type electrical property gaze improved macula mechanical behavior multidisciplinary programs research study response sensory system social treatment strategy

项目摘要

Project summary. Normal behavior and spatial orientation depend upon vestibular signals from the inner ear. There are two major subdivisions of the vestibular periphery: semicircular canals and otoconial organs. The former have been intensively studied. Otoconial organs are much less well understood, even though studies of central vestibular processing increasingly highlight their importance in control of posture, gaze, spatial orientation, and vegetative functions. Thus, there is a pressing need to understand this important subdivision of the labyrinth. We propose to address this need by analyzing the mechanical and biophysical origins of signals from a major otoconial organ, the utricle. Our experimental preparation is a turtle, one of the premier model systems for analyses of peripheral auditory and vestibular mechanisms. This multidisciplinary initiative analyzes utricular mechanisms at levels from behavior to cellular modeling. It builds on results from our current studies of biomechanics, which have yielded the most detailed data base on the structure and mechanics of the utricle available for any vertebrate. Aim 1 uses high-speed video recording and NMR images of the labyrinth to quantify the stimuli that utricular hair cells are exposed to in freely behaving animals. Aim 2 and Aim 3 combine experimental mechanics with biophysical and computational analyses to characterize important mechanical and hair cell responses to these stimuli. Aim 4 uses morphophysiology, information analysis, and modeling to quantify the resulting afferent signals and their information content, contrast these signals with hair cell responses to the same stimuli, and test hypotheses about the origins of signal diversity in utricular afferents. Thus, the proposed research continues our efforts to build the first detailed, quantitative description of the mechanisms that shape utricular signals to the CMS. Relevance. Vestibular dysfunction is a common cause of physician visits. It can be particularly disabling, and vestibular deficits are thus a significant medical, social, and financial concern. In spite of its importance, the vestibular system, and otoconial organs in particular, are far less well understood than other sensory systems. We need new knowledge of otoconial organ function to improve diagnosis and treatment strategies. By contributing to this knowledge, the proposed research is directly relevant to the mission of the NIDCD.

项目摘要。正常行为和空间取向取决于内部的前庭信号耳朵。前庭外围有两个主要细分：半圆形管和耳鼻肌器官。前者已经进行了深入的研究。耳鼻肌器官的理解程度不高得多，即使中央前庭处理的研究越来越强调它们在控制姿势，凝视，空间取向和营养功能。因此，迫切需要理解这一重要的迷宫的细分。我们建议通过分析机械和生物物理来满足这种需求来自主要耳机的信号的起源，即乌尔特。我们的实验准备是一只乌龟，是外围听觉和前庭机制分析的主要模型系统。这多学科计划分析了从行为到细胞建模的水平的尿液机制。它建立关于我们目前对生物力学研究的结果，这些研究产生了关于任何脊椎动物的肠结构和力学。 AIM 1使用高速视频录制和迷宫的NMR图像，以量化刺激性细胞的刺激。行为动物。 AIM 2和AIM 3将实验力学与生物物理和计算相结合分析以表征对这些刺激的重要机械和毛细胞反应。 AIM 4用途形态生理学，信息分析和建模，以量化产生的传入信号及其信息含量，将这些信号与对同一刺激的毛细单元响应进行对比，并检验假设关于Utricular传入中信号多样性的起源。因此，拟议的研究继续我们的努力为了构建第一个详细的详细描述，对将尿布信号塑造成CMS的机制进行了定量描述。关联。前庭功能障碍是医师就诊的常见原因。它可能是特别残疾的，因此，前庭缺陷是一个重大的医疗，社会和财务问题。尽管很重要，前庭系统，尤其是耳鼻肌器官，比其他感觉远没有理解系统。我们需要有关耳鼻肌器官功能的新知识，以改善诊断和治疗策略。通过为这一知识做出贡献，拟议的研究与 nidcd。