Procoagulants in Aging CARDIA Participants

促凝血剂在老年 CARDIA 参与者中的作用

基本信息

批准号：
7673413
负责人：
DAVID GREEN
金额：
$ 21.35万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-30 至 2010-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7673413
关键词：
Accounting Age Aging Ancillary Study Arterial Fatty Streak Atherosclerosis Blood Coagulation Factor Blood Coagulation Factor VII Blood Pressure Blood specimen Body mass index Cholesterol Clinical Coagulants Coronary Cross-Sectional Studies Development Diabetes Mellitus Diet Disease Event Evolution Factor VIII Fibrinogen Frequencies Glucose Haplotypes Hemostatic Agents High Density Lipoprotein Cholesterol Hyperlipidemia Hypertension Individual Insulin Insulin Resistance Interleukin-6 LDL Cholesterol Lipoproteins Laboratories Link Longitudinal Studies Low-Density Lipoproteins Measures Medial Participant Physical activity Plasma Process Race Reducing diet Reporting Research Personnel Risk Factors Role Sampling Severities Smoking Staging Testing Thick Time Triglycerides Weight Gain Woman Youth atherogenesis atherothrombosis cigarette smoking cohort coronary artery calcification critical period insight lifestyle factors male men middle age programs sex stomach cardia von Willebrand Factor

项目摘要

DESCRIPTION (provided by applicant): The role of procoagulant hemostatic factors in atherogenesis has been enigmatic. Increased plasma concentrations of procoagulants in youth may reflect early plaque development, and rising levels of procoagulants may mirror the severity and extent of vessel wall involvement by the disease. Insight into these processes may be gained from a longitudinal study of clotting factors in subjects beginning at the earliest stages of atherosclerosis (prior to age 30), and continuing through ages 40 and 50, when subclinical and clinical evidence of disease may be recognized. Such individuals with disease in middle age may have had elevated concentrations of procoagulants in youth and a greater rate of increase in levels over time as compared to those without evidence of atherosclerosis. A unique opportunity to test this hypothesis is presented by the CARDIA study, which for the past twenty years has serially examined a cohort of men and women who were ages 18-30 at inception. In an ancillary study, we measured levels of fibrinogen, factor VII, factor VIII, and von Willebrand factor in blood samples collected 1990-91 (Year 5) and 1992-93 (Year 7). In these Year 5 and 7 samples, obtained when subjects were in their 20's and 30's, cross-sectional analyses revealed that fibrinogen was higher in women than in men, factor VIII and von Willebrand factor were higher in blacks than in whites, and associations were reported of factor VII with cholesterol and triglycerides, and fibrinogen with body mass index, cholesterol, and LDL-cholesterol. Certain correlations were confined to specific sex/race groups, such as fibrinogen with blood pressure, triglycerides, and cigarette smoking in white males. These associations between established risk factors for atherosclerosis and procoagulants suggest common links to atherogenesis. We now wish to extend our previous study to the year 20 examination (2005-6). We shall examine the associations of rate of change in hemostatic factors with clinical and laboratory evidence of atheromatous disease, such as coronary calcification and increased carotid intimal/medial thickness, as well as changes in CARDIA measured lifestyle factors such as diet, physical activity, body mass index, and smoking, and the development of hypertension, hyperlipidemia, and diabetes. In addition, we shall assess whether changes in factor VII and factor VIII coagulant activities over time are associated with particular factor VII or factor VIII haplotypes. Study of CARDIA participants offers a unique opportunity to examine longitudinal changes in hemostatic components linked to atherothrombosis and to correlate their evolution with that of other recognized coronary risk factors during the critical period preceding clinical manifestations of disease.

描述（由申请人提供）：促凝剂止血因子在动脉粥样硬化中的作用是神秘的。青少年的血管凝剂的血浆浓度升高可能反映了早期牙菌斑的发育，而proc仪的含量升高可能反映出该疾病的血管壁参与的严重程度和程度。从动脉粥样硬化的最早阶段开始（30岁之前）的凝血因子的纵向研究，可以从对这些过程的纵向研究中获得洞察力，并在40岁和50岁时继续识别疾病的亚临床和临床证据。与没有动脉粥样硬化的证据相比，这种中年疾病的患者可能在青年中浓度升高，并且随着时间的流逝浓度升高，并且随着时间的推移浓度升高。 CADCIA研究提出了一个独特的检验该假设的机会，在过去的二十年中，该研究序列地研究了一群年龄在18-30岁时的男女队列。在一项辅助研究中，我们测量了1990 - 91年（第5年）和1992 - 93年收集的血液样本中纤维蛋白原，因子VII，VIII和VON Willebrand因子的水平。在这些第5年和7个样本中，当受试者在20年代和30年代的受试者中获得，横断面分析表明，女性的纤维蛋白原比男性高，黑人因子和冯·威勒布兰德因子高于白人，并且据报道与胆固醇和trigysterolter的因子VII的关联均与胆固醇和触发器的凝聚力和凝血素糖果一样。某些相关性局限于特定的性别/种族组，例如与血压，甘油三酸酯和白人男性吸烟的纤维蛋白原。既定的动脉粥样硬化风险因素与凝血剂之间的这些关联表明与动脉粥样硬化的共同联系。现在，我们希望将我们先前的研究扩展到20年级考试（2005-6）。我们将检查止血因素变化率与临床和实验室疾病的临床和实验室证据的关联，例如冠状动脉钙化和增加的颈动脉内膜/中间厚度，以及Cardia测量的生活方式因素的变化，例如饮食，体育活动，身体活动，体重指数以及吸烟，以及高血压，超级脂肪症和高脂质症和高血压，高脂，二世和二世。此外，我们将评估VII因子和VIII因子的凝结活性随着时间的变化是否与特定因子VII或VIII因子单倍型有关。对Cardia参与者的研究提供了一个独特的机会，可以检查与动脉粥样硬化相关的止血成分的纵向变化，并将其演变与疾病临床表现之前的关键时期相关联与其他公认的冠状动脉危险因素相关联。