UT Southwestern O'Brien Kidney Research Core Center

德州大学西南奥布莱恩肾脏研究核心中心

• 批准号: 7480286
• 负责人: Peter Igarashi
• 金额: $ 86.02万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-03 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7480286
• 关键词: Acute; Animal Model; Area; Basic Science; Biomedical Research; Cardiovascular Diseases; Cellular biology; Chronic Kidney Failure; Clinical; Clinical Investigator; Clinical Sciences; Collaborations; Congenital Abnormality; Core Facility; Cystic Kidney Diseases; Development; Developmental Biology; Disease; Functional disorder; Funding; Goals; Grant; Human; Human Genetics; Inflammation; Injury; Internal Medicine; Kidney; Kidney Diseases; Medical center; Minerals/Electrolytes Metabolism; Molecular Genetics; Nephrology; Pathogenesis; Pathology; Patients; Pediatrics; Physicians; Physiology; Research; Research Personnel; Scientist; Technology; Texas; Training; Transgenic Organisms; Translating; Translational Research; Universities; base; insight; interdisciplinary approach; molecular pathology; nephrogenesis; professor; programs; symposium

DESCRIPTION, OVERALL (provided by applicant): This is a new application for the establishment of a George M. O'Brien Kidney Research Core Center at the University of Texas Southwestern Medical Center at Dallas. The Director is Dr. Peter Igarashi, Professor of Internal Medicine and Pediatrics, and Chief of the Division of Nephrology. The overall goal of the Center is to promote bidirectional interactions between basic scientists and clinical researchers that will enhance our understanding of kidney development and pathophysiology and result in more effective treatments of kidney diseases and their complications. This goal will be achieved through the creation of new animal models of kidney diseases and the development of core facilities that will enable physician-scientists who are conducting basic research to more easily translate their findings to humans. Conversely, clinical investigators who are studying patients with renal diseases will identify molecular and genetic abnormalities that can then be studied to derive new insights into disease pathogenesis and treatment. To achieve these goals, the Center will support five Biomedical Research Cores, a Pilot & Feasibility Program, and an Educational Enrichment Program. The Biomedical Research Cores are: 1) Animal Models, 2) Physiology, 3) Cell Biology & Pathology, 4) Molecular Genetics, and 5) Clinical/Translational. The Cores will support ongoing, kidney- related research conducted at UT Southwestern, the North Texas region, nationally, and internationally. The research base consists of 41 externally funded investigators who are conducting basic research in the areas of kidney physiology & cell biology, injury & inflammation, developmental biology & molecular genetics, and renal cystic diseases. Clinical/translational research is conducted in the areas of acute & chronic kidney disease, kidney & cardiovascular disease, and electrolyte & mineral metabolism. The Center will be located in 15,000 sq ft of newly renovated space in the nephrology division and will utilize existing core facilities in human genetics, transgenic technologies, and molecular pathology. The Pilot & Feasibility Program will support two grants per year for investigators who are new to the field. The Educational Enrichment Program will include a research seminar, annual symposium, training grants, and courses offered by a new Dept. of Clinical Sciences. By strengthening existing collaborations and attracting outside investigators, the Center will promote new multidisciplinary approaches to understanding the causes and treatment of renal diseases.

总体描述（由申请人提供）： 这是在达拉斯德克萨斯大学西南医学中心建立乔治·M·奥布莱恩肾脏研究核心中心的新申请。主任是内科和儿科教授兼肾内科主任 Peter Igarashi 博士。该中心的总体目标是促进基础科学家和临床研究人员之间的双向互动，以增强我们对肾脏发育和病理生理学的理解，并更有效地治疗肾脏疾病及其并发症。这一目标将通过创建新的肾脏疾病动物模型和开发核心设施来实现，这些设施将使正在进行基础研究的医生科学家能够更轻松地将他们的发现转化为人类。相反，研究肾病患者的临床研究人员将识别分子和遗传异常，然后对其进行研究，以获得对疾病发病机制和治疗的新见解。为了实现这些目标，该中心将支持五个生物医学研究核心、一个试点和可行性计划以及一个教育丰富计划。生物医学研究核心是：1) 动物模型，2) 生理学，3) 细胞生物学和病理学，4) 分子遗传学，5) 临床/转化。该核心项目将支持德州大学西南分校、北德克萨斯地区、国内和国际范围内正在进行的肾脏相关研究。该研究基地由41名外部资助的研究人员组成，主要从事肾脏生理学与细胞生物学、损伤与炎症、发育生物学与分子遗传学、肾囊性疾病等领域的基础研究。临床/转化研究在急性和慢性肾脏疾病、肾脏和心血管疾病以及电解质和矿物质代谢领域进行。该中心将坐落于肾脏科新装修的 15,000 平方英尺空间内，并将利用人类遗传学、转基因技术和分子病理学方面的现有核心设施。试点和可行性计划每年将为新进入该领域的研究人员提供两笔资助。教育丰富计划将包括研究研讨会、年度研讨会、培训补助金以及新的临床科学系提供的课程。通过加强现有合作并吸引外部研究人员，该中心将推广新的多学科方法来了解肾脏疾病的原因和治疗。