UT Southwestern O'Brien Kidney Research Core Center

德州大学西南奥布莱恩肾脏研究核心中心

• 批准号: 8148016
• 负责人: Peter Igarashi
• 金额: $ 1.9万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-03 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8148016
• 关键词: Acute; Animal Model; Area; Basic Science; Biomedical Research; Cardiovascular Diseases; Cellular biology; Chronic Kidney Failure; Clinical; Clinical Investigator; Clinical Sciences; Collaborations; Congenital Abnormality; Core Facility; Cystic Kidney Diseases; Development; Developmental Biology; Disease; Functional disorder; Funding; Goals; Grant; Human; Human Genetics; Inflammation; Injury; Internal Medicine; Kidney; Kidney Diseases; Medical center; Minerals/Electrolytes Metabolism; Molecular Genetics; Nephrology; Pathogenesis; Pathology; Patients; Pediatrics; Physicians; Physiology; Research; Research Personnel; Scientist; Technology; Texas; Training; Transgenic Organisms; Translating; Translational Research; Universities; base; effective therapy; insight; interdisciplinary approach; molecular pathology; nephrogenesis; professor; programs; square foot; symposium

DESCRIPTION, OVERALL (provided by applicant): This is a new application for the establishment of a George M. O'Brien Kidney Research Core Center at the University of Texas Southwestern Medical Center at Dallas. The Director is Dr. Peter Igarashi, Professor of Internal Medicine and Pediatrics, and Chief of the Division of Nephrology. The overall goal of the Center is to promote bidirectional interactions between basic scientists and clinical researchers that will enhance our understanding of kidney development and pathophysiology and result in more effective treatments of kidney diseases and their complications. This goal will be achieved through the creation of new animal models of kidney diseases and the development of core facilities that will enable physician-scientists who are conducting basic research to more easily translate their findings to humans. Conversely, clinical investigators who are studying patients with renal diseases will identify molecular and genetic abnormalities that can then be studied to derive new insights into disease pathogenesis and treatment. To achieve these goals, the Center will support five Biomedical Research Cores, a Pilot & Feasibility Program, and an Educational Enrichment Program. The Biomedical Research Cores are: 1) Animal Models, 2) Physiology, 3) Cell Biology & Pathology, 4) Molecular Genetics, and 5) Clinical/Translational. The Cores will support ongoing, kidney- related research conducted at UT Southwestern, the North Texas region, nationally, and internationally. The research base consists of 41 externally funded investigators who are conducting basic research in the areas of kidney physiology & cell biology, injury & inflammation, developmental biology & molecular genetics, and renal cystic diseases. Clinical/translational research is conducted in the areas of acute & chronic kidney disease, kidney & cardiovascular disease, and electrolyte & mineral metabolism. The Center will be located in 15,000 sq ft of newly renovated space in the nephrology division and will utilize existing core facilities in human genetics, transgenic technologies, and molecular pathology. The Pilot & Feasibility Program will support two grants per year for investigators who are new to the field. The Educational Enrichment Program will include a research seminar, annual symposium, training grants, and courses offered by a new Dept. of Clinical Sciences. By strengthening existing collaborations and attracting outside investigators, the Center will promote new multidisciplinary approaches to understanding the causes and treatment of renal diseases.

描述，总体（由申请人提供）： 这是在达拉斯西南医学中心建立乔治·奥布莱恩肾脏研究核心中心的新应用。主任是内科和儿科教授彼得·伊加拉西（Peter Igarashi）博士，肾脏病科负责人。该中心的总体目标是促进基础科学家与临床研究人员之间的双向相互作用，这将增强我们对肾脏发育和病理生理学的理解，并导致对肾脏疾病及其并发症的更有效治疗。通过创建新的肾脏疾病动物模型以及核心设施的发展，将实现这一目标，这些核心设施将使医师科学家能够进行基础研究，从而更轻松地将其发现转化为人类。相反，正在研究肾脏疾病患者的临床研究人员将鉴定分子和遗传异常，然后可以研究这些异常，以获取有关疾病发病机理和治疗的新见解。为了实现这些目标，该中心将支持五个生物医学研究核心，一个试验和可行性计划以及一个教育丰富计划。生物医学研究核心是：1）动物模型，2）生理学，3）细胞生物学和病理学，4）分子遗传学，以及5）临床/转化。这些核心将支持正在进行的肾脏相关研究，该研究在UT西南部，北德克萨斯州，国内和国际上进行。该研究基础由41位由外部资助的研究者组成，他们正在肾脏生理与细胞生物学，损伤和炎症，发育生物学和分子遗传学以及肾囊性疾病领域进行基础研究。临床/翻译研究在急性和慢性肾脏疾病，肾脏和心血管疾病以及电解质和矿物质代谢领域进行。该中心将位于肾脏科的15,000平方英尺的新装修空间中，并将利用人类遗传学，转基因技术和分子病理学中的现有核心设施。飞行员与可行性计划将为该领域新手的调查人员提供每年两项赠款。教育丰富计划将包括一项研究研讨会，年度研讨会，培训补助金以及新的临床科学系提供的课程。通过加强现有的合作并吸引外部调查人员，该中心将促进新的多学科方法来了解肾脏疾病的原因和治疗。