FAMILIAL PSYCHIATRIC DISORDERS & SCHIZOPHRENIA

家族性精神疾病

• 批准号: 7627633
• 负责人: ROBERT F ASARNOW
• 金额: $ 1万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627633
• 关键词: Adult; Amygdaloid structure; Anterior; Attention; Attention deficit hyperactivity disorder; Brain; Child; Childhood; Clinical; Computer Retrieval of Information on Scientific Projects Database; Computer information processing; Data; Diagnosis; Disease; Funding; Genes; Grant; Hippocampus (Brain); Image; Impairment; Institution; Interview; Measures; Mental disorders; Neurocognitive; Patients; Personality Disorders; Phenotype; Protocols documentation; Questionnaires; Reporting; Research; Research Personnel; Resolution; Resources; Schizophrenia; Sensitivity and Specificity; Siblings; Source; Structure; Temporal Lobe; United States National Institutes of Health; Work; brain volume; family genetics; indexing; proband

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is a family genetic study comparing childhood onset schizophrenia and attention deficit hyperactivity disorder. The objective of this study is to identify genes associated with different facets of the schizophrenia phenotype. Our prior work corroborated earlier reports that childhood onset schizophrenia is a more familial form of schizophrenia than adult onset schizophrenia and helped to refine the characterization of the schizophrenia phenotype by comparing the sensitivity and specificity of three complimentary measures of the schizophrenia phenotype: 1) a diagnosis of schizophrenia; 2) presence of schizophrenic spectrum personality disorders defined by clinical interview or by questionnaire, and 3 neurocognitive impairments tapped by certain measures of attention/information processing. The neurocognitive measures were the most sensitive index of the schizophrenia phenotype while a diagnosis of schizophrenia was the most specific index of schizophrenia spectrum disorders . In addition, we have collected MRIs from 16 schizophrenic children and 24 normal control children using a high resolution SPGR image acquisition protocol. We have analyzed mesial temporal lobe volumes (amygdala and anterior and posterior hippocampus), total temporal lobe volume and total brain volume in order to replicate prior reports of significant reduction in mesial temporal structures in schizophrenic patients. We will begin to collect imaging data for siblings of child onset probands to examine the relationship between the volume of structures demonstrated in prior research to be either smaller or larger in schizophrenic patients than normal controls, and the presence of the three alternative measures of the schizophrenia phenotype cited above. In addition, we will attempt to identify genes associated with the presence of morphometric changes in the brains of schizophrenic probands and their siblings.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目是一项家庭遗传研究，比较儿童时期精神分裂症和注意力缺陷多动障碍。这项研究的目的是确定与精神分裂症表型不同方面相关的基因。我们先前的工作证实了早期的报道，即童年的精神分裂症比成人精神分裂症是一种更家族性的精神分裂症形式，并通过比较了三种精神分裂症表型的敏感性和特异性，有助于完善精神分裂症表型的表征：1）诊断疗法诊断的精神分裂症。 2）由临床访谈或问卷定义的精神分裂谱性格障碍的存在，以及通过某些注意力/信息处理的措施来利用的3种神经认知障碍。神经认知度量是精神分裂症表型的最敏感指数，而精神分裂症的诊断是精神分裂症谱系障碍最特定的指数。此外，我们使用高分辨率SPGR图像采集方案从16名精神分裂症儿童和24名正常对照儿童中收集了MRI。我们已经分析了中叶颞叶体积（杏仁核和前后海马），总颞叶量和总脑体积，以便复制精神分裂症患者中介体颞叶结构的显着减少的报道。我们将开始收集儿童发作概率兄弟姐妹的成像数据，以检查精神分裂症患者中先前研究中证明的结构体积比正常对照组更大或大，并且在上面引用的精神分裂症表型的三种替代方法的存在。此外，我们将尝试鉴定与精神分裂症概率及其兄弟姐妹大脑中形态变化相关的基因。