Non-invasive assessment and modulation of brain-gut interoception in humans

人类脑肠内感受的无创评估和调节

• 批准号: 10591158
• 负责人: VITALY NAPADOW
• 金额: $ 27.27万
• 依托单位: SPAULDING REHABILITATION HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10591158
• 关键词: Adult; Amygdaloid structure; Animal Model; Anterior; Area; Brain; Brain Stem; Brain imaging; Brain region; Breathing; Calibration; Cell Nucleus; Cells; Clinical; Cross-Over Studies; Esophagus; Evaluation; Feedback; Food; Four-dimensional; Functional Gastrointestinal Disorders; Functional Magnetic Resonance Imaging; Gastrointestinal Diseases; Gastrointestinal tract structure; Goals; Human; Hypothalamic structure; Image; Individual; Ingestion; Insula of Reil; Interoception; Intervention; Lead; Link; Magnetic Resonance Imaging; Measures; Mechanoreceptors; Methods; Molecular; Muscle Tonus; Nerve; Nodose Ganglion; Nucleus solitarius; Organism; Outcome; Pathway interactions; Peristalsis; Physiology; Pontine structure; Process; Proxy; Randomized; Rectum; Relaxation; Reporting; Research; Role; Signal Transduction; Single-Blind Study; Source; Spinal; Stomach; Techniques; Thalamic structure; Upper digestive tract structure; Vagus nerve structure; Vertebral column; Visceral; brain magnetic resonance imaging; cingulate cortex; cohort; contrast enhanced; dorsal motor nucleus; experimental study; gastrointestinal; gut-brain axis; improved; insight; kinematics; mechanotransduction; neural circuit; neuroimaging; neuroregulation; novel; parabrachial nucleus; rectal; response; tool; vagus nerve stimulation

PROJECT SUMMARY/ABSTRACT Interoception refers to the representation of the internal states of an organism, and includes the processes by which it senses, interprets, integrates, and regulates signals from within itself. Interoception is increasingly viewed as a bidirectional process between the brain and body, in which multiple feedback and feedforward loops lead to an internal representation of the body. The vagus nerve is intimately involved in autonomic control of the upper gastrointestinal (GI) tract, with afferent projections to medullary brainstem nuclei. In turn, interoceptive pathways can also be directly targeted for clinically beneficial neuromodulation and non-invasive neuromodulatory techniques that interact with brainstem vagal circuitry, including transcutaneous auricular vagal nerve stimulation (taVNS), have been reported to modulate efferent visceral vagal pathways via the engagement of nucleus tractus solitarii (NTS). However, broader understanding of taVNS effects on gastric function and brain response to gastric interoceptive signaling is needed, and requires tools to directly probe the gut-brain axis in humans. In our study, we will combine a fully non-invasive experimental framework including sequential gastric and brain Magnetic Resonance Imaging (MRI) with calibrated meal ingestion and MRI- compatible taVNS to evaluate the modulation of visceral interoception along the brain-gut axis. Aim 1 will evaluate gastric function and brain response to gastric interoceptive signaling following calibrated meal ingestion. In Aim 2, we will then investigate taVNS modulation of gastric function and brain response to gastric interoceptive signaling. The proposed study will contribute new insights into the bidirectional gut-brain interaction underlying gastric interoception, and its modulation via non-invasive neuromodulatory techniques that specifically target interoceptive pathways (i.e. taVNS).

项目摘要/摘要 互感是指有机体内部状态的表示，包括 它感知，解释，集成和调节自身内部的信号。际观察越来越多 被视为大脑和身体之间的双向过程，其中多次反馈和馈送 循环导致身体的内部表示。迷走神经密切参与自主神经 控制上胃肠道（GI）的控制，并具有对髓质脑干核的传入。反过来， 互感途径也可以直接针对临床上有益的神经调节和无创 与脑干迷走路电路相互作用的神经调节技术，包括经皮耳 据报道，迷走神经刺激（TAVN）通过 Nucleus tractus solitarii（NTS）的参与。但是，对TAVNS对胃的更广泛理解 需要功能和大脑对胃互感信号的反应，并且需要工具直接探测 人类肠道轴。在我们的研究中，我们将结合一个完全无创的实验框架 具有校准的饮食和MRI-MRI- 兼容的TAVN，以评估沿着脑脉管轴的内脏互动的调节。目标1意志 评估胃功能和大脑对胃间互感信号的反应 摄取。在AIM 2中，我们将研究胃功能的TAVN调制和脑对胃的反应 互感信号传导。拟议的研究将为双向肠脑提供新的见解 相互作用的相互作用胃间歇及其通过非侵入性神经调节技术调节 该专门针对的是跨感受途径（即TAVNS）。