"THEORY & COMP IN MOL BIO PHY", AUG 9-20, 2006, LA JOLLA, CA

“理论

• 批准号: 7601649
• 负责人: Alan J Garfinkel
• 金额: $ 0.89万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601649
• 关键词: Address; Anatomy; Cardiac; Cells; Computer Retrieval of Information on Scientific Projects Database; Coupling; Diffusion; Equation; Fibrosis; Funding; Grant; Heterogeneity; Infarction; Institution; Intervention; Muscle Contraction; Play; Reaction; Research; Research Personnel; Resources; Role; Source; Thinking; Tissues; United States National Institutes of Health; Ventricular Fibrillation; Work; prevent; sudden cardiac death; theories; tissue preparation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In normal cardiac conduction, a roughly rectilinear wave of electrical activation causes the wave of muscular contraction that is the heartbeat. In ventricular fibrillation (VF), the leading cause of sudden cardiac death, the wave of electrical activation breaks up into a multi-wave chaotic state. Our research has focused on the question: why does the wave break up? The traditional view was that the wave was broken up by anatomic heterogeneity: such factors as fibrosis, infarct, and loss of cell-to-cell electrical coupling were thought to play the decisive role. However, nonlinear dynamicists have proposed another mechanism: rectilinear waves, governed by reaction-diffusion partial differential equations, can become unstable and break up, even in perfectly homogeneous tissue, due to electrical instabilities. Our work in cardiac tissue preparations has shown that interventions that address these electrical instabilities can prevent fibrillation. (Garfinkel, Kim et al. 2000) The objective of this research is to answer the questions: how important are these two types of factors (anatomical heterogeneity and purely dynamical instability) in generating and sustaining fibrillation? How do they interact?

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在正常的心脏传导中，大致向直线的电动激活导致心跳引起的肌肉收缩波。在心室纤颤（VF）中，心脏猝死的主要原因，电活激活的波浪分化为多波动的混沌状态。我们的研究集中在一个问题上：为什么浪潮破裂？ 传统观点是，波浪是由解剖异质性分解的：诸如纤维化，梗塞和细胞对细胞电耦合的损失之类的因素被认为起着决定性作用。 然而，非线性动力学家提出了另一种机制：由反应扩散部分微分方程控制的直线波可能会变得不稳定和破裂，即使在完全均匀的组织中，由于电不稳定性。 我们在心脏组织制剂中的工作表明，解决这些电不稳定性的干预措施可以防止纤颤。 （Garfinkel，Kim等，2000） 这项研究的目的是回答以下问题：这两种因素（解剖异质性和纯粹的动态不稳定性）在产生和维持纤颤中有多重要？ 他们如何互动？