2020 Meiosis Gordon Research Conference and Gordon Research Seminar

2020年减数分裂戈登研究大会暨戈登研究研讨会

基本信息

批准号：
9980585
负责人：
Paula Elaine Cohen
金额：
$ 1万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9980585
关键词：
Academia Address Aneuploidy Animal Model Architecture Biological Biological Models Cell Cycle Cell Cycle Checkpoint Cell Cycle Regulation Cell division Cells Cellular biology Chromatin Chromosome Pairing Chromosome Segregation Chromosomes Collaborations Communities Congenital Abnormality DNA Repair Data Defect Discipline Down Syndrome Edward&apos s syndrome Ensure Environment Epigenetic Process Eukaryota European Event Fostering Functional disorder Gene Expression Gene Expression Regulation Genetic Recombination Genomic Instability Germ Cells Goals Growth Haploidy Hour Human Infertility Insecta Institution International Investigation Knowledge Lead Learning Light London Meiosis Meiotic Recombination Mentors Mentorship Microscopy Molecular Names Nature Nematoda North America Oncogenes Oral Participant Plants Postdoctoral Fellow Process Production Regulation Reproduction Reproductive Health Research Research Personnel Resolution Running Science Scientist Slide Spontaneous abortion Time Underrepresented Minority Variant Vertebrates Woman Work biophysical analysis career catalyst chromosome movement college comparative egg experience faculty mentor fascinate fungus genome editing graduate student improved innovation meetings novel peer posters prevent programs sperm cell stillbirth success symposium theories undergraduate student

项目摘要

Meiosis is the specialized cell division cycle that gives rise to haploid gametes for sexual reproduction. Given the conserved nature of many of the distinct events in meiosis, there is a surprising degree of variation in meiotic regulation across sexually reproducing species. Exploring both these distinct differences and commonalities is crucial to our understanding of how meiosis is regulated to ensure the production of euploid gametes. Nowhere is this more important than in our own species, in which defects in meiosis are responsible for the extremely high rates of infertility, miscarriage, and birth defects, such as Trisomies 18 and 21 (Down syndrome). Furthermore, the meiotic program encompasses unique molecular processes underlying cell cycle control and checkpoint activation, DNA repair and recombination, chromatin architecture, chromosome movements, and gene expression. This immense complexity can inform a wide variety of biological sub- disciplines, including germ cell biology, DNA repair and cancer, gene regulation and epigenetics, and chromosome dynamics and spindle assembly, to name a few. Partial support is requested for the premier international meeting on Meiosis as part of the Gordon Research Conferences (GRC), and the accompanying trainee-led Meiosis Gordon Research Seminar (GRS), taking place at Colby-Sawyer College in New London, NH on June 7-12 and June 6-7, 2020, respectively. The goals are: (1) To harness the strength of various model systems and state-of-the-art technical approaches to shed light on the molecular mechanisms underpinning meiosis; (2) To identify novel scientific themes and collaborations that can accelerate the pace of discovery in our field; and (3) To promote an environment of inclusivity and to identify key ingredients for success of our trainees, our diversity representation, and women. The GRC will gather 180 participants to present and discuss cutting-edge, mostly unpublished research addressing critical topics in meiosis. The program comprises 9 plenary sessions that broadly address current issues in the initiation and progression of meiotic recombination, meiotic progression and cell cycle checkpoints, regulation of meiotic gene expression, chromosome pairing and synapsis, chromosome dynamics, and chromosome segregation. Four poster sessions will allow trainees to present their data and to engage in critical discussions about their work with leaders in the field. An open forum Power Hour will be convened with the aims of addressing the challenges faced by women in science, and supporting the professional growth of women in our community. The GRS consists of three plenary and two poster sessions, and will include 60 participants, including several invited faculty mentors. The GRS provides opportunities for trainees to present their work, to network, and to discuss the topics that will be covered in more depth during the GRC. Our community enjoys and promotes strong representation by women, but we will further enhance our diversity by offering attendance support to under- represented minorities, young investigators, and researchers from predominantly undergraduate institutions.

减数分裂是一种特殊的细胞分裂周期，产生用于有性生殖的单倍体配子。给定由于减数分裂中许多不同事件的保守性，存在令人惊讶的变异程度有性生殖物种的减数分裂调节。探索这些明显的差异和共性对于我们理解如何调节减数分裂以确保整倍体的产生至关重要配子。这对于我们自己的物种来说最为重要，其中减数分裂的缺陷是造成这种情况的原因不孕症、流产和出生缺陷（如 18 三体症和 21 三体症）的发生率极高（下综合症）。此外，减数分裂程序涵盖细胞周期背后的独特分子过程控制和检查点激活、DNA 修复和重组、染色质结构、染色体运动和基因表达。这种巨大的复杂性可以为多种生物亚种提供信息学科，包括生殖细胞生物学、DNA修复和癌症、基因调控和表观遗传学，以及仅举几例，染色体动力学和纺锤体组装。请求总理提供部分支持作为戈登研究会议（GRC）一部分的减数分裂国际会议，以及伴随的由实习生主导的减数分裂戈登研究研讨会 (GRS)，在新伦敦科尔比-索耶学院举行，新罕布什尔州分别于2020年6月7日至12日和6月6日至7日举行。其目标是：（1）发挥各方面的力量模型系统和最先进的技术方法来阐明分子机制支持减数分裂； (2) 确定可以加快步伐的新颖的科学主题和合作我们领域的发现； (3) 促进包容性环境并确定包容性的关键要素我们的学员、我们的多元化代表以及女性的成功。 GRC将聚集180名参与者展示并讨论针对减数分裂关键主题的前沿、大部分未发表的研究。这该计划包括 9 场全体会议，广泛讨论启动和进展中的当前问题减数分裂重组、减数分裂进程和细胞周期检查点、减数分裂基因表达的调节、染色体配对和突触、染色体动力学和染色体分离。四张海报课程将允许学员展示他们的数据并参与关于他们工作的批判性讨论该领域的领导者。将召开开放论坛“Power Hour”，旨在应对挑战科学界女性面临的问题，并支持我们社区女性的职业发展。 GRS 由三场全体会议和两场海报会议组成，将有 60 名与会者参加，其中包括几位受邀者教师导师。 GRS 为学员提供展示工作、建立人际网络和讨论的机会 GRC 期间将更深入讨论的主题。我们的社区享有并促进强大的女性代表，但我们将通过向不足的人提供出席支持来进一步增强我们的多样性代表少数族裔、年轻研究者和主要来自本科院校的研究人员。