IDENTIFICATION OF LTR RETROTRANSPOSONS IN VERTEBRATE GENOMES

脊椎动物基因组中 LTR 反转录转座子的鉴定

• 批准号: 7601541
• 负责人: HAIXU TANG
• 金额: $ 0.03万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601541
• 关键词: Algorithms; Class; Communities; Compatible; Computer Retrieval of Information on Scientific Projects Database; Elements; Funding; Genome; Genomics; Grant; Human; Indiana; Indium; Information Technology; Institution; Methods; Research; Research Personnel; Resources; Retrotransposon; Services; Site; Source; Standards of Weights and Measures; United States National Institutes of Health; Universities; Work; base; novel; open source; programs; vertebrate genome

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to utilize the advanced computing facility to identify novel LTR retrotransposon from verterbrate genomic sequences. LTR retrotranposons is a class of transposible elements in eukaryotic genomes. We recently developed a fast and sensitive algorithm to identify these elements. We want to apply this method to intensively search for novel elements in human and other vertebrate genomes. Our program will be made available to the scientific community on all Teragrid sites, and is currently released as open source. 30000 Service Units are requested. This estimate is based on our existing work using IU Bigred and local clusters. Indiana University is a TeraGrid Resource Partner, and as a result there will be excellent local support available from IU's University Information Technology Services, so we will be able to enhance our application to be compatible with the Common Teragrid Standard Services (CTSS) very effectively.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们建议利用先进的计算设施来鉴定从弗特脑基因组序列中的新型LTR逆转录子。 LTR逆转录子是真核基因组中的一类替元。我们最近开发了一种快速敏感的算法来识别这些元素。我们希望将这种方法深入搜索人和其他脊椎动物基因组中的新元素。我们的计划将在所有TERAGRID网站上向科学界提供，目前作为开源发布。请求30000个服务单元。该估算基于我们使用IU Bigred和本地群集的现有工作。印第安纳大学是TeraGRID资源合作伙伴，因此，IU的大学信息技术服务将提供出色的本地支持，因此我们将能够增强我们的应用程序，以与普通的TeraGRID标准服务（CTSS）兼容。