MRI OF MURINE CARDIAC FUNCTION

小鼠心脏功能的 MRI

• 批准号: 7601209
• 负责人: BENNETT B CHIN
• 金额: $ 0.5万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601209
• 关键词: 3-Dimensional; Algorithms; Applications Grants; Cardiac; Computer Retrieval of Information on Scientific Projects Database; Data; Echocardiography; Functional disorder; Funding; Genetic; Grant; Heart failure; Image; Institution; Investigation; Left Ventricular Ejection Fraction; Magnetic Resonance Imaging; Measurement; Mus; Pilot Projects; Research; Research Personnel; Resolution; Resources; Screening procedure; Source; Time; Transgenic Mice; Transgenic Model; United States National Institutes of Health; Ventricular Function; base; single photon emission computed tomography; technique development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Investigations of the genetic basis of cardiac dysfunction, using transgenic mice, require accurate characterization of ventricular function. High spatial resolution MRI of greater than 16 time frames per cardiac cycle is difficult to achieve in a short MRI imaging session. Our hypothesis is that rapid acquisition, high temporal resolution SPECT has sufficient spatial resolution to accurately characterize 3 dimensional measurements of cardiac function. The aim of this pilot study is to correlate rapid, high temporal resolution SPECT measurements of ventricular function (LVEF and RVEF from end-diastolic and end-systolic volumes) with those obtained by MRI. If rapid SPECT can accurately characterize cardiac function, an algorithm for echocardiography primary screening, SPECT for secondary functional characterization, and MRI for high spatial resolution measurements will be proposed to fully characterize cardiac dysfunction in transgenic models of heart failure. This preliminary data would be used in a grant proposal to support further development of these techniques.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 使用转基因小鼠对心脏功能障碍的遗传基础的研究需要对心室功能进行准确的表征。 在短暂的MRI成像会议中，很难实现每个心脏周期大于16个时间范围的高空间分辨率MRI。 我们的假设是快速获取，高时间分辨率SPECT具有足够的空间分辨率，可以准确表征心脏功能的3维测量。这项试验研究的目的是将心室功能（LVEF和RVEF的末端舒张和末期终止量和终止2卷）与MRI获得的快速，高的时间分辨率SPECT测量相关联。 如果快速SPECT能够准确地表征心脏功能，则将提出用于超声心动图主要筛选，次级功能表征的SPECT和高空间分辨率测量的MRI算法，以充分表征心脏失效转基因模型中心脏功能障碍。 该初步数据将用于赠款建议中，以支持这些技术的进一步开发。