Small Animal PET/SPECT/CT Molecular Imaging

小动物 PET/SPECT/CT 分子成像

基本信息

批准号：
8053517
负责人：
BENNETT B CHIN
金额：
$ 60万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-01 至 2012-03-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This proposal is to obtain funding for a state-of-the-art small animal PET/CT molecular imaging instrument. Our institution has committed resources to support, develop and maintain this instrument. It will provide small animal high resolution in vivo radionuclide molecular imaging with precise anatomic correlation using computed tomography (CT). High-resolution positron emission tomography (PET) provides a non-invasive method to visualize molecular events in vivo. This is critical to medical science investigations because it will enable basic science studies of in vivo mechanisms of disease. Oncologists, cardiologists, and other investigators throughout the University and Medical Center will be able to perform longitudinal, in vivo molecular imaging studies in contemporary small animal models. The basic science of radiochemistry will also tremendously benefit through testing and development of novel radiotracers in vivo. Radio chemists can efficiently determine the in vivo biodistribution, radiation dosimetry, and radiotracer kinetics of novel radiotracers. Furthermore, advanced therapeutics can also be tested and developed in in vivo small animal models, using radiotracers which can monitor the early molecular events of a therapeutic response. A wide array of advanced therapeutics may include both novel drug compounds and novel strategies such as cell based therapies. In addition to contributing to understanding basic mechanisms of pathophsiology, radiotracer techniques have proven human safety for both diagnostic and therapeutic applications. Novel radiotracers, radiotracer methods, and therapeutic monitoring techniques are, therefore, highly translational to in vivo human studies. PUBLIC HEALTH RELEVANCE: We plan to use this instrument to study the reasons why medical diseases occur, to test new methods to detect disease, and to test new therapies before they are used in humans. This can greatly advance medical science and the treatment of cancer, heart disease, and a wide variety of other human diseases. Studying disease in live tissues is essential to understanding how diseases occur, testing new non-invasive tests, and testing safety and efficacy of new therapies before human use.

描述（由申请人提供）：本提案旨在为最先进的小动物 PET/CT 分子成像仪器获得资金。我们的机构已投入资源来支持、开发和维护该工具。它将使用计算机断层扫描 (CT) 提供小动物高分辨率体内放射性核素分子成像，并具有精确的解剖学相关性。高分辨率正电子发射断层扫描 (PET) 提供了一种非侵入性方法来可视化体内分子事件。这对于医学科学研究至关重要，因为它将能够对疾病的体内机制进行基础科学研究。整个大学和医学中心的肿瘤学家、心脏病学家和其他研究人员将能够在当代小动物模型中进行纵向体内分子成像研究。放射化学的基础科学也将通过体内新型放射性示踪剂的测试和开发而受益匪浅。放射化学家可以有效地确定新型放射性示踪剂的体内生物分布、辐射剂量测定和放射性示踪动力学。此外，还可以使用放射性示踪剂在体内小动物模型中测试和开发先进的治疗方法，放射性示踪剂可以监测治疗反应的早期分子事件。一系列广泛的先进疗法可能包括新的药物化合物和新的策略，例如基于细胞的疗法。除了有助于理解病理生理学的基本机制之外，放射性示踪剂技术还证明了诊断和治疗应用对人体的安全性。因此，新型放射性示踪剂、放射性示踪剂方法和治疗监测技术对于人体体内研究具有高度转化作用。公共卫生相关性：我们计划使用该仪器来研究医学疾病发生的原因，测试检测疾病的新方法，并在新疗法用于人类之前对其进行测试。这可以极大地推进医学科学以及癌症、心脏病和多种其他人类疾病的治疗。研究活体组织中的疾病对于了解疾病如何发生、测试新的非侵入性测试以及在人类使用前测试新疗法的安全性和有效性至关重要。