Novel Fluid Management System for Microfluidic Devices

用于微流体装置的新型流体管理系统

• 批准号: 7657325
• 负责人: ALAN J CISAR
• 金额: $ 46.96万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2010-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7657325
• 关键词: Ablation; Area; Automation; Behavior; Biochemical; Biochemical Reaction; Biological Assay; Blood Cells; Caring; Cell Separation; Cells; Characteristics; Chemicals; Clinical; Complex; Development; Devices; Diagnosis; Diagnostic; Diagnostic tests; Dimensions; Drug Infusion Systems; Electrodes; Electrolyses; Electronics; Engineering; Environment; Equipment; Evaluation; Evolution; Exhibits; Foundations; Future; Gases; Gene Chips; Government; Health; Healthcare; Home environment; Hour; Housing; Infusion Pumps; Laboratories; Lasers; Learning; Licensing; Liquid substance; Location; Longevity; Manufactured Materials; Manufacturer Name; Marketing; Mechanics; Medical; Methods; Microfluidic Analytical Techniques; Microfluidic Microchips; Microfluidics; Movement; Names; Operative Surgical Procedures; Patient Care; Patients; Performance; Persons; Phase; Physicians; Positioning Attribute; Preclinical Drug Evaluation; Price; Process; Production; Proteomics; Public Health; Pump; Reagent; Regulatory Affairs; Research Personnel; Respiratory Diaphragm; Sample Size; Scheme; Science; Small Business Innovation Research Grant; Solid; Source; Specialist; Surface; Syringes; System; Systems Analysis; Techniques; Technology; Testing; Work; Workplace; base; chemical synthesis; commercialization; cost; cost effective; design; engineering design; experience; fluid flow; genetic analysis; improved; industry partner; meetings; milliliter; millimeter; nanolitre; new technology; next generation; novel; pressure; programs; prototype; public health relevance; reaction rate; research and development; tool

DESCRIPTION (provided by applicant): Microfluidics is a branch of science dealing with the behavior, precise control and manipulation of microliter and nanoliter volumes of fluids. Its applications include blood-cell-separation, biochemical assays, chemical synthesis, genetic analysis (e.g., gene-chips and proteomics chips), drug screening, electrochromatography, etc. One of the most difficult problems in bringing microfluidic products to the market is the lack of appropriate methods to accurately transfer and manage small quantities of fluid. Many microfluidic devices rely on relatively complex and costly mechanically activated pumps that are unsuitable for many applications. Techniques that are built into the microfluidic device and operate by electrically activated processes, such as electroosmosis and piezoelectrics, are often insufficiently reliable. Thus, there is a need to develop cheap and accurate fluid management systems and components. This proposal describes a novel, low cost micropump for fluid management that is based on electrochemical (i.e., electrolysis & fuel cell) principles. Its benefits are: (1) accurate delivery of microliter quantities of fluids, (2) low cost of manufacture (it is based on a single moving part), (3) ability to operate at very high backpressures if required (>100 psi), and (4) scaleable to meet a variety of user applications (flow rates range from microliters per minute to milliliters per minute). In Phase I, we streamlined the micropump assembly techniques and demonstrated the micropump's process and cost advantages. Practical uses of the micropump were demonstrated, such as for controlling a laboratory colorimetric enzymatic reaction on a microfluidic diagnostic chip. The micropump's reliability was also demonstrated through long- term continuous operation. The low cost, accuracy, and reliability of the micropump strongly differentiates it from competing methods, making this micropump uniquely appropriate for inclusion into high volume medical products (cartridges and microfabricated fluidic chips etc.) that are designed to be disposable. This is important because the field of microfluidics is moving in this direction. The proposed Phase II project involves materials development, engineering design, process control development and microfluidics applications testing that, if successful, will position the technology for future transition into a manufacturing or product environment. Our program includes working with a medical equipment manufacturer and with regulatory affairs specialists. The focus is on exploiting the unique features of the micropump for use in future drug infusion systems. PUBLIC HEALTH RELEVANCE The proposed technology will benefit public health by providing cost-effective system components for bringing next generation health care products and diagnostic tests to the market place. Cost effective next generation health care products and diagnostics will allow physicians to provide improved and more individualized patient treatment and care.

描述（由申请人提供）：微流体学是科学的一个分支，涉及流体的微氧和纳米素体积的行为，精确控制和操纵。它的应用包括血细胞分离，生化测定，化学合成，遗传分析（例如基因芯片和蛋白质组学芯片），药物筛查，电色谱学等。在将微流体产物带到市场上的最困难问题之一是缺乏适当的方法来准确地转移和管理小额量的流体量。许多微流体设备依赖于相对复杂且代价高昂的机械激活的泵，这些泵不适合许多应用。在微流体设备中内置并通过电动过程（例如电流和压电）运行的技术通常不足以可靠。因此，有必要开发廉价且准确的流体管理系统和组件。该提案描述了一种用于流体管理的新型，低成本的微型泵，该微型量基于电化学（即电解和燃料电池）原理。它的好处是：（1）准确递送微量液数量的流体，（2）制造成本低（基于单个移动零件），（3）如果需要（> 100 psi），在非常高的背压（> 100 psi）和（4）可缩放的用户应用程序（每分钟每分钟至毫升的流量范围）中以非常高的背压（> 100 PSI）进行操作。在第一阶段，我们简化了微型聚集组装技术，并证明了微型群的过程和成本优势。证明了微型聚会的实际用途，例如用于在微流体诊断芯片上控制实验室比色酶促反应。还通过长期连续操作证明了微泵的可靠性。微型泵的低成本，准确性和可靠性将其与竞争方法有很大的区别，使该微泵完全适合将其纳入大量的医疗产品（墨盒和微生物芯片等）。这很重要，因为微流体的领域正在朝这个方向移动。拟议的第二阶段项目涉及材料开发，工程设计，过程控制开发和微流体应用测试，如果成功，将将技术定位为将来过渡到制造或产品环境。我们的计划包括与医疗设备制造商以及监管事务专家合作。重点是利用微型群的独特特征，以在未来的药物输注系统中使用。 公共卫生相关性该提议的技术将通过提供具有成本效益的系统组件来使公共卫生受益，以将下一代医疗保健产品和诊断测试带入市场。具有成本效益的下一代医疗保健产品和诊断将使医生能够提供改进和更个性化的患者治疗和护理。