Monitoring the hemodynamic response to therapy in diabetic retinopathy

监测糖尿病视网膜病变治疗的血流动力学反应

• 批准号: 10661730
• 负责人: Amani A Fawzi
• 金额: $ 46.55万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10661730
• 关键词: Ablation; Address; Adult; Affect; Age; Aneurysm; Angiography; Area; Automation; Blindness; Blood; Blood Flow Velocity; Blood Vessels; Blood capillaries; Blood flow; Burn injury; Cell physiology; Clinical; Clinical Trials; Collaborations; Color; Complications of Diabetes Mellitus; Computer software; Coupled; Data; Development; Diabetes Mellitus; Diabetic Retinopathy; Disease; Extravasation; Eye; Functional disorder; Goals; Hemorrhage; Image; Imaging Techniques; Individual; Interruption; Ischemia; Knowledge; Lasers; Lateral; Light Coagulation; Liquid substance; Maps; Measurement; Measures; Medical; Microaneurysm; Monitor; Natural History; Nerve Degeneration; Non-Invasive Detection; Ophthalmology; Optics; Outcome; Outcome Measure; Pathology; Patients; Performance; Perfusion; Peripheral; Pharmaceutical Preparations; Pharmacotherapy; Photography; Physiological; Reproducibility; Resolution; Retina; Retinal Hemorrhage; Scanning; Selection for Treatments; Speed; Surface; Technology; Testing; Thick; Time; Vascular Diseases; Vision; adaptive optics; adaptive optics scanning laser ophthalmoscopy; alternative treatment; clinical development; cost; density; diabetic; endothelial repair; flexibility; hemodynamics; improved; insight; macula; macular edema; meter; multimodality; non-invasive imaging; novel; novel therapeutics; optical imaging; preservation; proliferative diabetic retinopathy; quantitative imaging; response; retinal angiogenesis; retinal imaging; retinal ischemia; standard of care; success; therapy design; therapy outcome; tool; treatment response

This proposal aims to study retinal blood flow, detected by non-invasive imaging, during medical treatments for diabetic retinopathy. Success of this proposal will lead to the development of non-invasive measurements that can guide clinicians as they manage patients with sight threatening complications of diabetic retinopathy.

该提案旨在研究在医学治疗期间通过非侵入性成像检测到的视网膜血流 糖尿病视网膜病变。该提案的成功将导致非侵入性测量的发展 可以指导临床医生治疗患有威胁视力的糖尿病视网膜病变并发症的患者。

项目成果

Macrophage-Like Cell Density Is Increased in Proliferative Diabetic Retinopathy Characterized by Optical Coherence Tomography Angiography.

• DOI: 10.1167/iovs.62.10.2
• 发表时间: 2021-08-02
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Ong JX;Nesper PL;Fawzi AA;Wang JM;Lavine JA
• 通讯作者: Lavine JA

Early-stage macular telangiectasia type 2 vascular abnormalities are associated with interdigitation zone disruption.

• DOI: 10.1371/journal.pone.0259811
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Ong JX;Zandi R;Fawzi AA
• 通讯作者: Fawzi AA

Deep Capillary Geometric Perfusion Deficits on OCT Angiography Detect Clinically Referable Eyes with Diabetic Retinopathy.

• DOI: 10.1016/j.oret.2022.05.028
• 发表时间: 2022-12
• 期刊: OPHTHALMOLOGY RETINA
• 影响因子: 4.5
• 作者: Nesper, Peter L.;Ong, Janice X.;Fawzi, Amani A.
• 通讯作者: Fawzi, Amani A.

Global challenges in the management of diabetic retinopathy in women with pre-gestational diabetes.

• DOI: 10.1111/ceo.14173
• 发表时间: 2022-09
• 期刊: Clinical & experimental ophthalmology
• 影响因子: 4

Hemodynamic Effects of Anti-Vascular Endothelial Growth Factor Injections on Optical Coherence Tomography Angiography in Diabetic Macular Edema Eyes.

• DOI: 10.1167/tvst.11.10.5
• 发表时间: 2022-10-03
• 期刊: TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
• 影响因子: 3
• 作者: Song, Jessica;Huang, Bonnie B.;Ong, Janice X.;Konopek, Nicholas;Fawzi, Amani A.
• 通讯作者: Fawzi, Amani A.