Inorganic Ion Exchange Materials for 90Sr/90Y Generator

90Sr/90Y发生器用无机离子交换材料

• 批准号: 6654359
• 负责人: ALAN J CISAR
• 金额: $ 52.02万
• 依托单位: LYNNTECH, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-15 至 2006-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6654359
• 关键词: biomedical equipment development; chemical synthesis; neoplasm /cancer radioimmunotherapy; radiochemistry; radiopharmacology; radiotracer; strontium; technology /technique development; yttrium

DESCRIPTION (provided by applicant): Because it is an energetic pure beta emitter with a half-life on the scale of days (64.1 hr) 90Y is seeing increasing interest as an isotope for use as a radiation source for radioimmunotherapy (RIT). Current processes for obtaining 90Y involve extracting and purifying the 90Y produced by the decay of 90Sr in solution using a liquid-liquid extraction process. The isotope is produced at a centralized location and shipped to users worldwide. The generator proposed here will permit the production of the desired isotope locally in a hospital or regional radiopharmacy where it can be used immediately. Phase I identified two inorganic ion exchange materials that can be loaded with a "cow" of 90Sr and "milked" to produce a carrier-free solution of 90Y ready for immediate use. In Phase II this technology will be further refined and used in the design of a generator capable of delivering a useful quantity of 90Y on a weekly basis in a chemical form suitable for radiopharmaceutical applications. The generator will be fabricated and its efficacy will be demonstrated. The superior long-term stability of the inorganic ion exchanger compared to organic ion exchange materials will be demonstrated. PROPOSED COMMERCIAL APPLICATION: Radioimmunotherapy, where an antibody selectively delivers a radiation source directly to a tumor, is seeing increasing interest as a means of attacking tumors by delivering a therapeutic dose of radiation to the tumor with minimal exposure for other organs. Currently 90Y is produced by a complex multistep process process and supplied from a central source, with clinicians dependent on reliable delivery to have the isotope they need when they need it. The generator proposed here would make 90Y as readily available as 99m Tc is now and greatly increase the use of this valuable therapy. As an alternative, the developed technology could be utilized on a larger scale to simplify the current 90Y production method.

描述（由申请人提供）：因为它是一种充满活力的纯贝塔 半衰期为天（64.1小时）90Y的发射器正在观察 作为辐射源的同位素越来越受到关注 放射免疫治疗（RIT）。目前获得 90Y 的流程包括 提取并纯化90Sr在溶液中衰变产生的90Y 采用液-液萃取工艺。同位素产生于 集中地点并运送给世界各地的用户。 这里提出的发生器将允许生产所需的同位素 在当地可以使用的医院或地区放射性药物房 立即地。第一阶段确定了两种无机离子交换材料，可以 装载 90Sr“奶牛”并“挤奶”以产生无载体溶液 90Y 可立即使用。在第二阶段，这项技术将进一步 改进并用于能够提供有用的发电机的设计 每周 90Y 的数量，其化学形式适合 放射性药物应用。发电机将被制造及其 功效将被证明。卓越的长期稳定性 无机离子交换剂与有机离子交换材料相比 证明了。 拟议的商业应用：放射免疫疗法，即抗体选择性地将放射源直接传递到肿瘤，作为一种通过向肿瘤传递治疗剂量的放射线而对其他器官的暴露最小化来攻击肿瘤的手段，人们越来越感兴趣。 目前，90Y 是通过复杂的多步骤工艺过程生产的，并由中央来源提供，临床医生依靠可靠的交付来在需要时获得所需的同位素。 这里提出的发生器将使 90Y 像现在的 99m Tc 一样容易获得，并大大增加这种有价值的疗法的使用。 作为替代方案，所开发的技术可以更大规模地利用，以简化当前的 90Y 生产方法。