Straw Detector Positron Emission Mammography System

吸管探测器正电子发射乳腺X线摄影系统

• 批准号: 7586620
• 负责人: JEFFREY L LACY
• 金额: $ 37.89万
• 依托单位: PROPORTIONAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7586620
• 关键词: Anguish; Benign; Biopsy; Breast; Breast Cancer Detection; Cancer Patient; Detection; Development; Diagnosis; Diagnostic Procedure; Electronics; Gases; Health Care Costs; Healthcare Systems; Heart; Housing; Image; Lead; Length; Malignant Neoplasms; Mammography; Methods; Organ; Pain; Patients; Performance; Phase; Pilot Projects; Positron; Positron-Emission Tomography; Psyche structure; Radiation Tolerance; Reading; Resolution; Roentgen Rays; Simulate; System; Testing; Tissues; Translations; Woman; attenuation; base; calcification; cost; design; detector; improved; innovation; malignant breast neoplasm; mortality; prototype; radiation detector; tumor; uptake; voltage

DESCRIPTION (provided by applicant): Breast cancer is the second most prevalent cancer in women, with a mortality rate of 40,000 per year in the US. However, if detected and treated early, more than 95% of breast cancer patients will survive. Current method for breast cancer detection relies heavily on X-ray mammography, which produces many false positive findings. These false positive readings cause substantial mental anguish in patients and in many cases, costly and painful biopsies. A full 80% of all biopies uncover only benign masses and calcifications at an estimated annual cost of 2.5 billion dollars. To improve breast cancer detection, we propose a highly innovative design for a dedicated Positron Emission Mammography (PEM) camera utilizing long, linear, lead-walled straw (LWS) detectors that provide high spatial resolution and rigorously accurate depth of interaction determination. Thus detectors with ample field of view to contain the entire breast without translation can be employed and very close detector pair spacing can be used without resolution degradation. Our proposed camera offers markedly increased sensitivity and resolution with substantially reduced cost compared to crystal-based PEM cameras under development. Phase I of the project will achieve proof of concept by constructing and testing two substantial submodules of a full scale camera. In Phase II, a full scale high sensitivity prototype camera will be constructed and tested.

描述（由申请人提供）：乳腺癌是女性第二大癌症，在美国，每年40,000的死亡率为40,000。但是，如果早点发现和治疗，超过95％的乳腺癌患者将存活。当前的乳腺癌检测方法在很大程度上取决于X射线乳房X线摄影，这会产生许多假阳性发现。这些假肯定的读数会导致患者和许多情况下的精神痛苦，即代价高昂和痛苦的活检。在所有自由主义者中，全部80％仅发现良性质量和钙化，估计每年成本为25亿美元。为了改善乳腺癌的检测，我们提出了一种高度创新的设计，该设计使用长，线性的，铅壁的稻草（LWS）探测器进行专用的正电子发射乳房摄影（PEM）摄像头，可提供高空间分辨率并严格准确地进行相互作用的确定。因此，可以使用具有足够视场的探测器，可以使用无需翻译的整个乳房，并且可以在没有分辨率降解的情况下使用非常紧密的检测器对间距。与正在开发的基于晶体的PEM摄像机相比，我们提出的相机具有明显提高的灵敏度和分辨率，成本大大降低。该项目的第一阶段将通过构建和测试全尺度摄像头的两个实质性的子模型来实现概念证明。在第二阶段，将构建和测试全尺度的高灵敏度原型相机。