Novel small animal PET scanner using 2.0 mm lead-walled straw detectors

使用 2.0 毫米铅壁吸管探测器的新型小动物 PET 扫描仪

• 批准号: 7326740
• 负责人: JEFFREY L LACY
• 金额: $ 20万
• 依托单位: PROPORTIONAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-05 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7326740
• 关键词: 3-Dimensional; Aging; Animal Model; Animals; Arts; Back; Benchmarking; Biological Process; Blur; Brain imaging; Breast; Caliber; Clinical assessments; Count; Depth; Development; Devices; Dimensions; Disease; Electronics; Elements; Employee Strikes; Event; Facility Construction Funding Category; Funding; Futility; Gamma Rays; Gases; Grant; Grouping; Heart; Human; Image; Imaging Device; Imaging Phantoms; Imaging Techniques; Immunity; Invasive; Investigation; Lead; Length; Life; Location; Marketing; Measures; Methods; Mission; Modeling; Molecular; Monitor; Mus; Numbers; Operative Surgical Procedures; Organ; Performance; Phase; Placement; Positioning Attribute; Positron; Positron-Emission Tomography; Property; Radioisotopes; Rate; Rattus; Relative (related person); Research; Resolution; Rotation; Simulate; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Solid; Source; Staging; Structure; System; Techniques; Technology; Test Result; Testing; Time; Tracer; United States National Institutes of Health; Variant; attenuation; base; cost; density; design; detector; human disease; improved; in vivo; instrument; instrumentation; molecular imaging; mouse model; novel; novel strategies; optical imaging; prevent; quality assurance; quantum; reconstruction; response; simulation; size; tool; tumor; uptake

DESCRIPTION (provided by applicant): Molecular imaging techniques are among the most powerful tools for non-invasive investigation of disease and fundamental biological processes in vivo and are therefore of high significance to the mission of the NIH. Positron Emission Tomography (PET) provides sensitivity to molecular tracer concentrations several orders of magnitude less than any other imaging technique offering a large fundamental sensitivity advantage. Also PET is able to produce rigorous quantitative 3D uptake distribution uniquely free of attenuation and scatter effects giving it another strong advantage over other methods such as optical imaging. Since mouse is by far the most popular species in molecular imaging, high resolution is of exceptional importance. A number of commercial scintillator based dedicated small animal PET scanners are on the market but are limited to a useful volumetric imaging resolution of no better than 5 ¿l and are very costly ($500,000 - $850,000). Recent attempts to reduce crystal size to levels needed to improve resolution performance have shown that depth of interaction (DOI) error reduces improvement to marginal levels despite substantial cost increase demonstrating the futility of the approach. Development of a low cost, high resolution PET scanner is proposed based on revolutionary detector elements composed of lead walled straws (LWS). Compared to scintillation crystal detectors, this technology is intrinsically many fold less expensive to produce and because the position of each detected gamma ray is located precisely in 3D space, fundamentally superior camera configurations can be employed to great advantage. Detectors can be placed very close to the imaged subject and events accepted over a substantially larger solid angle providing unparalleled sensitivity while maintaining immunity from resolution degradation caused by DOI. Unlike crystal devices with DOI problems, resolution performance of LWS devices scales precisely with detector dimension. Based on scaling of performance achieved in a 4 mm straw pilot device backed up by a comprehensive Monte Carlo study an optimally designed 2 mm LWS camera can reach at least a volumetric resolution of 1.2 ¿l and with recently demonstrated resolution refinements should achieve a further reduction to 0.58 ¿l. Furthermore using a very small detector module count of 28, a 4 fold increase in sensitivity and throughput can be achieved. In stark contrast to crystal devices the LWS camera design produces highly uniform sensitivity and resolution over its entire very large field of view. Feasibility will be demonstrated by construction of two densely packed 200 straw LWS modules of 30 - 50 cm length. Imaging performance using a rotating gantry will be evaluated through phantom testing. Lower cost combined with quantum improvement in quality will afford an exceptional new molecular imaging tool.

描述（由申请人提供）：分子成像技术是对体内心理生物过程的非侵入性投资的最强大的工具，并且对NIH的任务具有很高的意义。因此，宠物能够产生严格的三d摄取分布的独特关注和散射效果，使其与其他方法相比，诸如光学成像等其他方法。 L非常昂贵（$ 500,000- $ 850,000）。革命性的探测器元素由铅壁（LW）组成对受试者进行成像，并在基本的实体上进行，同时可以保持免疫力RR ESLOUSE降解，而DOI引起的降解与具有多齿状的晶体设备不同，分辨率执行的设备尺度缩放了具有检测器维度的尺度。体积分辨率为1.2€ l并在最近证明的分辨率改进应进一步降低到0.58````'''。 l。使用探测器模块的数量为28，敏感性和刺激性增加。长度使用旋转的幻影测试与质量相结合，并进行质量较低。