Straw Detector Positron Emission Mammography System

吸管探测器正电子发射乳腺X线摄影系统

• 批准号: 7495552
• 负责人: JEFFREY L LACY
• 金额: $ 55.25万
• 依托单位: PROPORTIONAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7495552
• 关键词: Anguish; Benign; Biopsy; Breast; Breast Cancer Detection; Cancer Patient; Count; Depth; Detection; Development; Diagnosis; Diagnostic Procedure; Electronics; Gases; Health Care Costs; Healthcare Systems; Heart; Housing; Image; Lead; Length; Malignant Neoplasms; Mammography; Methods; Organ; Pain; Patients; Performance; Personal Satisfaction; Phase; Pilot Projects; Positron; Positron-Emission Tomography; Psyche structure; Radiation Tolerance; Rate; Reading; Resolution; Roentgen Rays; Simulate; System; Testing; Tissues; Translations; Woman; attenuation; base; calcification; concept; cost; design; detector; improved; innovation; malignant breast neoplasm; mortality; prototype; radiation detector; size; tumor; uptake; voltage

DESCRIPTION (provided by applicant): Breast cancer is the second most prevalent cancer in women, with a mortality rate of 40,000 per year in the US. However, if detected and treated early, more than 95% of breast cancer patients will survive. Current method for breast cancer detection relies heavily on X-ray mammography, which produces many false positive findings. These false positive readings cause substantial mental anguish in patients and in many cases, costly and painful biopsies. A full 80% of all biopies uncover only benign masses and calcifications at an estimated annual cost of 2.5 billion dollars. To improve breast cancer detection, we propose a highly innovative design for a dedicated Positron Emission Mammography (PEM) camera utilizing long, linear, lead-walled straw (LWS) detectors that provide high spatial resolution and rigorously accurate depth of interaction determination. Thus detectors with ample field of view to contain the entire breast without translation can be employed and very close detector pair spacing can be used without resolution degradation. Our proposed camera offers markedly increased sensitivity and resolution with substantially reduced cost compared to crystal-based PEM cameras under development. Phase I of the project will achieve proof of concept by constructing and testing two substantial submodules of a full scale camera. In Phase II, a full scale high sensitivity prototype camera will be constructed and tested.

描述（由申请人提供）：乳腺癌是女性中第二常见的癌症，在美国每年的死亡率为 40,000 人。然而，如果及早发现和治疗，超过 95% 的乳腺癌患者将存活下来。目前乳腺癌检测方法严重依赖X射线乳房X线照相术，这会产生许多假阳性结果。这些假阳性读数会给患者带来巨大的精神痛苦，并且在许多情况下，还会导致昂贵且痛苦的活检。 80% 的活组织检查仅发现良性肿块和钙化，估计每年的费用为 25 亿美元。为了改善乳腺癌检测，我们提出了一种高度创新的设计，专门用于正电子发射乳房X线摄影（PEM）相机，该相机利用长、线性、铅壁吸管（LWS）探测器，提供高空间分辨率和严格精确的相互作用深度确定。因此，可以采用具有足够视场以包含整个乳房而无需平移的探测器，并且可以使用非常接近的探测器对间距而不会降低分辨率。与正在开发的基于晶体的 PEM 相机相比，我们提出的相机可显着提高灵敏度和分辨率，同时大幅降低成本。该项目的第一阶段将通过构建和测试全尺寸相机的两个重要子模块来实现概念验证。在第二阶段，将建造并测试全尺寸高灵敏度原型相机。