Enhanced Contrast Imaging for Screening of Early Pancreatic Cancer

增强对比成像筛查早期胰腺癌

基本信息

批准号：
7672295
负责人：
NICUSOR IFTIMIA
金额：
$ 14.66万
依托单位：
PHYSICAL SCIENCES, INC
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-11 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7672295
关键词：
Abdomen Acinar Cell Address Age Animal Model Animals Area Award Binding Biological Blood Circulation Cancer Etiology Cancer cell line Cancerous Capital Catheters Cell Line Cells Clinical Clinical Research Collaborations Computer software Connective Tissue Data Data Set Detection Development Diagnosis Diagnostic Diagnostic Neoplasm Staging Disease Ductal Ductal Epithelial Cell Ductal Epithelium Dyes Early Diagnosis Effectiveness Encapsulated Endocrine Endoscopy Engineering Epidermal Growth Factor Receptor Epithelial Equipment Evaluation Feasibility Studies Flour Fluorescence Fluorescent Dyes Frequencies Funding Gastrointestinal tract structure Gelatin Genes Goals Gold Government Growth Hand Hepatic Duct Histology Human Image Indocyanine Green Intravenous Label Lasers Lateral Lesion Light Local Therapy Location Lung Lymphoid Tissue Malignant Neoplasms Malignant neoplasm of gastrointestinal tract Malignant neoplasm of pancreas Measurement Methods Modeling Molecular Probes Morbidity - disease rate Morphology Nanotechnology Normal Cell Nude Mice Optical Coherence Tomography Optics Organ Organ Size Outcome Pancreas Pancreatic Ductal Adenocarcinoma Pancreatic duct Patients Peptides Persons Peutz-Jeghers Syndrome Pharmaceutical Preparations Phase Probability Process Property Qualifying Reporting Research Research Personnel Resolution Scanning Screening for cancer Screening procedure Sensitivity and Specificity Signal Transduction Solutions Source Specificity Specimen Speed Staging Structure Surface Survival Rate Symptoms System Techniques Technology Testing Therapeutic Three-Dimensional Image Time Tissues Topical application Translating Ultrasonography United States United States National Institutes of Health Universities Work base bile duct cancer cell cancer diagnosis cancer site chronic pancreatitis data acquisition design fluorescence imaging fluorophore imaging modality imaging probe improved in vivo instrument instrumentation millimeter minimally invasive mortality mouse model nanoparticle neoplastic neoplastic cell optical imaging pancreatic neoplasm particle physical science programs public health relevance targeted delivery tool tumor tumor xenograft

项目摘要

DESCRIPTION (provided by applicant): This proposal addresses a real need for an improved technology for early detection and rapid screening of ductal pancreatic cancer. Very recent advances in nanotechnology and high resolution optical coherence tomography (OCT) imaging have led to the development of new investigative tools capable of probing biological tissues at the cellular level. These tools can be used to localize abnormal neoplastic cells and expedite the cancer screening process. Physical Sciences Inc. (PSI), in collaboration with Northeastern University (NEU), proposes to develop a technology that could be used for screening of early stage epithelial cancerous lesions of the pancreatic duct. Endoscopically guided high-resolution OCT imaging, combined with fluorescence imaging, will be used to localize abnormal lesions within the tissue. Gold-coated gelatin-based particles, loaded with a fluorophore and functionalized to recognize the epidermal growth factor receptor (EGFR), will be topically or intravenously delivered to the body to target cancer cells, indicate cancer location, and enhance the contrast of OCT imaging. In Phase I, this technology will be tested on various pancreatic cancer cell lines in cultures and in an orthotropic mouse model of human pancreatic cancer. The Phase I results and observations will be used to improve this technology in a Phase II program. A pilot in vivo study on a large number of animals will be performed in Phase II to test the effectiveness of this technology for early stage ductal pancreatic cancer screening. PUBLIC HEALTH RELEVANCE: The proposed research could substantially improve cancer screening and surveillance, allowing for detection at an early stage when it is treatable and more easily curable. It is well established that earlier cancer diagnosis results in improved clinical outcomes, decreased morbidity, and reduced mortality from disease.

描述（由申请人提供）：该提案解决了对早期检测和快速筛查导管癌的改进技术的真正需求。纳米技术和高分辨率光学相干断层扫描（OCT）成像的最新进展已导致开发了能够在细胞水平探测生物组织的新研究工具。这些工具可用于定位异常的肿瘤细胞并加快癌症筛查过程。物理科学公司（PSI）与东北大学（NEU）合作，提议开发一种可用于筛查胰管的早期上皮癌变病变的技术。内镜下引导的高分辨率OCT成像，结合荧光成像，将用于在组织内定位异常病变。基于荧光团并识别表皮生长因子受体（EGFR）的金色涂层明胶颗粒将被局部或静脉内输送到人体上，以指示癌细胞，表明癌症的位置，并增强OCT成像的对比度。在第一阶段，该技术将在培养物的各种胰腺癌细胞系和人类胰腺癌的正交小鼠模型中进行测试。 I期结果和观察结果将用于在II期计划中改善该技术。在II期中，将对大量动物进行一项针对大量动物的试点研究，以测试该技术对早期导管胰腺癌筛查的有效性。公共卫生相关性：拟议的研究可以大大改善癌症的筛查和监测，从而在早期阶段进行可治疗且更容易治愈时进行检测。众所周知，较早的癌症诊断可改善临床结果，降低发病率和疾病死亡率降低。