Temple SIREN Emergency Care Clinical Research Hub

Temple SIRN 紧急护理临床研究中心

基本信息

批准号：
9973240
负责人：
NINA T GENTILE
金额：
$ 15.53万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-15 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9973240
关键词：
Academic Medical Centers Accident and Emergency department Acute Address Adherence Adult African American Agreement Ancillary Study Area Blood Coagulation Disorders Blunt Trauma Cardiology Caring Catchment Area Cessation of life Childhood Chronic Cities Clinical Clinical Research Clinical Trials Clinical Trials Network Collaborations Communication Communities Community Hospitals Conduct Clinical Trials Country County Data Discipline Emergency Care Emergency Medicine Emergency Situation Emergency research Emotional Enrollment Ethnic Origin Evaluation Financial cost Funding Future Geographic Locations Grant Healthcare Heart Arrest Heart failure Height Hematology Hispanics Hospitals Individual Informatics Injury Institution Language Lead Leadership Lung Medicine Minority Modeling Monitor Neurological emergencies New Jersey Observational Study Patient Care Patient Recruitments Patients Philadelphia Population Population Heterogeneity Population Study Prevention program Process Protocols documentation Provider Race Reading Records Registries Research Research Design Research Infrastructure Research Personnel Research Project Grants Research Subjects Research Support Respiratory distress Role Rural Scientist Site Societies Socioeconomic Status Specialist System Time Training Translating Trauma Traumatic Brain Injury United States National Institutes of Health Universities Work acute care acute stroke base bench to bedside career data management design disability emergency service responder experience improved improved outcome injured interest meetings member minority communities outreach population health pre-clinical rural area social determinants suburb symposium translational study trauma care trauma centers treatment trial trend violence prevention webinar working group

项目摘要

The Temple-led Emergency care research network comprised of multiple community and academic medical centers and EMS providers throughout Philadelphia, eastern PA and NJ have effectively conducted clinical trials together since 2007. To meet the needs for specific study enrollment, the group has grown from 2 to now 5 actively enrolling sites and is prepared to expand to 10 hospitals with the highest volume emergency and trauma centers and 6 of the busiest EMS systems all with an expressed interest in participating in pre- hospital research to cover the entire Philadelphia metro area and the suburban and rural areas that surround it. This large hub-spoke network spans very diverse populations including extremely poor, mostly African American and Hispanic communities in densely populated cities such as Philadelphia, Chester and Reading, to highly affluent areas in suburban Montgomery county, and to rural Bucks and Berks county in PA Dutch country. Temple-SIREN hub and spoke leaders have had career-long commitment to emergency care and are active in translational, pre-hospital and clinical research in heart failure and cardiac arrest, respiratory distress, disorders of coagulation and treatment of exsanguination, acute stroke and traumatic brain injury and severe penetrating and blunt trauma, all fertile ground for SIREN studies. These clinician-scientists in Emergency Medicine, Cardiology, Pulmonary, Hematology, Neurocritical, and Trauma care are leaders in their fields and set the standards for care for patients with acute illness and injury. Through collaboration and hub oversight, the Temple-SIREN group expects to significantly contribute SIREN studies' enrollment. In addition, we plan to stay ahead of the curve by translating preclinical work to the bedside and using our highly diverse regional network for population studies to address racial and social determinants of emergency care in our region. The Temple-SIREN HUB staff plans to work closely with participating site investigators and coordinators from multiple disciplines to efficiently execute SIREN studies. Mechanisms to enhance efficiency and quality of clinical research across sites include use of a common informatics system to identify potential study patients; frequent communication with investigators and coordinators via webinars and conference calls; diligent site management focused on good clinical research practices and compliance and yearly HUB-spoke meetings to provide additional training by study role. Temple-SIREN investigators and coordinators are expect to work with the SIREN clinical coordinating center and data management center and ad hoc working groups to design and operationalize SIREN studies. The Temple-SIREN HUB team would benefit from participating in this coordinated approach to emergency care research as would the people of Philadelphia and the surrounding communities served by our hospitals and EMS systems.

天普大学领导的紧急护理研究网络由多个社区和学术机构组成费城、宾夕法尼亚州东部和新泽西州的医疗中心和 EMS 提供商已有效地开展了自 2007 年起一起进行临床试验。为了满足特定研究入组的需求，该小组已从 2 目前已有 5 个积极注册站点，并准备扩展到 10 家急诊量最大的医院和创伤中心以及 6 个最繁忙的 EMS 系统都表示有兴趣参与预治疗医院研究覆盖整个费城都会区及其周边的郊区和农村地区。这个庞大的中心辐射网络涵盖了非常多样化的人群，其中包括极度贫困的人，其中大部分是非洲人费城、切斯特和雷丁等人口稠密城市的美国和西班牙裔社区蒙哥马利县郊区的高度富裕地区以及宾夕法尼亚州荷兰巴克斯和伯克斯县的农村地区国家。 Temple-SIREN 中心和辐射领导人在整个职业生涯中都致力于紧急护理，并且积极参与心力衰竭和心脏骤停、呼吸窘迫、凝血障碍和失血、急性中风、创伤性脑损伤和严重出血的治疗穿透性创伤和钝性创伤，都是 SIREN 研究的沃土。这些处于紧急状态的临床医生科学家医学、心脏病学、肺病学、血液学、神经重症学和创伤护理是各自领域的领导者，制定急性疾病和受伤患者的护理标准。通过协作和中心监督， Temple-SIREN 小组预计将为 SIREN 研究的入学人数做出重大贡献。此外，我们计划通过将临床前工作转化为临床工作并利用我们高度多样化的区域来保持领先地位人口研究网络，旨在解决我们地区紧急护理的种族和社会决定因素。 Temple-SIREN HUB 工作人员计划与参与的现场调查员和协调员密切合作来自多个学科的人员有效地执行 SIREN 研究。提高效率和质量的机制跨站点临床研究包括使用通用信息系统来识别潜在的研究患者；通过网络研讨会和电话会议与调查人员和协调员经常沟通；勤奋的网站管理层专注于良好的临床研究实践和合规性以及每年的 HUB 发言会议，以按学习角色提供额外培训。 Temple-SIREN 调查员和协调员预计将与 SIREN临床协调中心和数据管理中心以及特设工作组来设计和实施 SIRN 研究。 Temple-SIREN HUB 团队将从参与本次活动中受益与费城及周边地区的人民一样，采取协调一致的紧急护理研究方法我们的医院和 EMS 系统服务的社区。