Recording central blood flow velocity waveform by conformal ultrasonic devices

利用适形超声装置记录中心血流速度波形

• 批准号: 9924597
• 负责人: Sheng Xu
• 金额: $ 17.96万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9924597
• 关键词: Acoustics; Address; Arteries; Awareness; Back; Blood; Blood Flow Velocity; Blood Pressure; Blood flow; Caliber; Cardiac Output; Cardiovascular Diseases; Catheterization; Catheters; Clinical; Complex; Device Designs; Devices; Diagnosis; Doppler Effect; Doppler Ultrasonography; Electronics; Elements; Frequencies; Gold; Guidelines; Health Care Costs; Human; Human Resources; Implant; Island; Location; Manuals; Maps; Measurement; Measures; Mechanics; Medical; Membrane; Methods; Monitor; Morphologic artifacts; Motion; Movement; Noise; Organ; Outcome; Patient Monitoring; Patients; Perception; Performance; Peripheral; Phase; Preventive care; Protocols documentation; Pulmonary artery structure; Research; Research Project Grants; Savings; Signal Transduction; Skin; Stretching; System; Technology; Time; Tissues; Training; Transducers; Translating; Ultrasonic Transducer; Ultrasonic wave; Ultrasonics; Ultrasonography; blood flow measurement; clinical practice; data streams; design; design and construction; disease diagnosis; elastomeric; electric impedance; experience; experimental study; hemodynamics; human subject; human tissue; iatrogenic injury; improved; iterative design; materials science; mechanical properties; monitoring device; mortality; operation; optical fiber; patient safety; personalized medicine; phase 2 designs; prototype; standard of care; voltage; wearable device

PROJECT SUMMARY This proposed project aims to develop a soft wearable transducer array for continuous, accurate, and non- invasive measurement of blood flow velocity waveforms. The blood flow velocity waveform can provide critical information about the major organ activities and psychiatric state changes, which would help raise patient awareness, assist preventive care, and serve as the basis for personalized medicine. Conventional measurement protocols include catheter implants, which is invasive and risky, and Doppler ultrasonography, which is heavily user-dependent and often has errors and artifacts. This research is distinct from the existing methods, because it offers several unique features. First, due to its low-profile form factors, the wearable ultrasonic device enables continuous measurement of the blood flow velocity waveform without constricting the natural movement of the subject. Second, this device has similar mechanical properties to the human skin and therefore can achieve a conformal and intimate contact with the skin, which allows accurate and stable measurements. Third, the phased array control mechanism facilitates focusing and steering the ultrasonic beam at any locations with predefined incident angles, which enhances the signal-to-noise-ratio and removes user errors for manual operations. Towards that end, by combining materials science, mechanical design, and electronics integration, we will use an iterative design of experiments to understand and optimize the performance of a single ultrasonic transducer. Then, we will develop phased array control mechanism on a wearable platform to achieve ultrasonic beam focusing and steering. After that, we will integrate the stretchable transducer array with the phased array control circuit to achieve continuous and accurate recording of blood flow velocity waveforms. The proposed research is the first of its kind to use a soft, stretchable system to diagnose and monitor deep tissues under the skin. The availability of a comfortable, non-invasive blood flow monitoring device will make a fundamental difference in how related diseases are diagnosed and treated, which will have a direct impact on the clinical practices. This wearable device will also shift the public perception of blood flow monitoring, promote preventive care, and provide unprecedented data streams for medical professionals, which will translate into significant reductions in associated mortality and healthcare costs. !

项目概要 该项目旨在开发一种软​​可穿戴换能器阵列，用于连续、精确和非 血流速度波形的侵入式测量。血流速度波形可以提供关键的 有关主要器官活动和精神状态变化的信息，这将有助于提高患者的情绪 意识，协助预防性护理，并作为个性化医疗的基础。传统的 测量方案包括导管植入，这是侵入性且有风险的，以及多普勒超声检查， 它严重依赖于用户，并且经常存在错误和伪影。这项研究与现有研究不同 方法，因为它提供了一些独特的功能。首先，由于其低调的外形，可穿戴设备 超声波装置可以连续测量血流速度波形，而不会限制血流速度 主体的自然运动。其次，该装置具有与人体皮肤相似的机械特性， 因此可以实现与皮肤的保形和紧密接触，从而实现精确和稳定 测量。第三，相控阵控制机制有利于超声波的聚焦和转向 光束以预定义的入射角照射到任何位置，从而增强了信噪比并消除了 手动操作的用户错误。为此，通过结合材料科学、机械设计和 电子集成，我们将使用迭代的实验设计来理解和优化 单个超声波换能器的性能。然后，我们将在相控阵控制机制上开发 可穿戴平台实现超声波束聚焦和转向。之后，我们将整合可拉伸的 换能器阵列配合相控阵控制电路实现连续、准确的血液记录 流速波形。这项研究是同类研究中第一个使用柔软、可拉伸的系统来 诊断和监测皮下深层组织。提供舒适、无创的血流 监测设备将对相​​关疾病的诊断和治疗方式产生根本性的改变， 这将直接影响临床实践。这种可穿戴设备也将改变公众 血流监测的感知，促进预防性护理，并提供前所未有的数据流 医疗专业人员，这将大大降低相关死亡率和医疗保健 成本。 ！