UC Davis Environmental Health Sciences Core Center

加州大学戴维斯分校环境健康科学核心中心

基本信息

批准号：
9918177
负责人：
Irva Hertz-Picciotto
金额：
$ 157万
依托单位：
UNIVERSITY OF CALIFORNIA AT DAVIS
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-05 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9918177
关键词：
Academia Achievement Address Adopted Advisory Committees Affect Air Air Pollution Animals Area Asthma Biochemical Biological Biological Assay Biological Markers Biological Models Biological Sciences Biometry California Cell Culture Techniques Chemicals Climate Collaborations Communities Community Actions Community Developments Complex Country Devices Diabetes Mellitus Dimensions Disease Dose Ecology Endocrine system Engineering Ensure Environment Environmental Exposure Environmental Health Environmental Impact Environmental Pollution Epidemiology Faculty Fostering Functional disorder Funding Generations Genetic Genomics Geography Health Health Professional Health Sciences Home environment Human Immune Immune system In Vitro Individual Infrastructure Integrative Medicine Interdisciplinary Study International Intervention Knowledge Leadership Learning Link Malignant Neoplasms Measurement Medicine Metabolic Methods Mission Modeling Molecular Molecular Target Monitor National Institute of Environmental Health Sciences Nervous system structure Neurodevelopmental Disorder Outcome Pathway interactions Patients Physiological Pilot Projects Policies Policy Maker Population Predisposition Process Public Health Public Health Practice Pump Radar Reproductive system Research Research Personnel Resources Respiratory System Risk Schools Science Scientist Severities Social Conditions Social Justice Strategic Planning Stress Target Populations Technology Testing Time Toxic effect Toxicokinetics Training Translating Translational Research Translations Underrepresented Minority Veterinary Medicine Vision Wildfire Woman Work behavior influence career clinical care college design disability dissemination research environmental justice epidemiology study epigenomics experimental study exposed human population exposure route health equity health science research improved in silico interdisciplinary approach interdisciplinary collaboration interest member metabolomics new technology novel nutrition portability prevent programs prototype recruit resilience respiratory response sensor social media success technology development transcriptomics translational approach working group

项目摘要

PROJECT SUMMARY - Overall The mission of the UC Davis Environmental Health Sciences Center (EHSC) is to advance understanding of environmentally induced disease and disability and to translate this knowledge into interventions, new practices or policy changes that reduce those exposures or mitigate their effects on health. The EHSC brings together faculty from seven schools and colleges engaged in environmental health sciences (EHS) research spanning molecular biosciences, environmental science, engineering, pathophysiology, biostatistics, epidemiology, and community development, with relevance to human conditions. The EHSC has made huge strides in less than 4 years. Among its notable achievements, the EHSC has: broken through silos, transformed interdisciplinary collaboration into the standard modus operandi among our members, attracted both new and established investigators, and placed environmental health on the radar of other Centers throughout UC Davis. Increasingly, EHSC members are engaging with community stakeholders and seeking to address community-driven questions. A few highlights of EHSC accomplishments are: 1) a novel vivarium facility for air pollution health studies using real-time air pumped from a heavily trafficked tunnel; 2) a program of research on exposures and health effects in response to hugely destructive wildfires now commonplace throughout the western U.S.; 3) recruitment of many new investigators, including two underrepresented minority women; establishment of a strong presence on social media. Guided by the NIEHS 2018-2023 Strategic Plan and the NIEHS Translational Research Framework, we adopted three overarching theme areas: 1) interdisciplinary translational EHS linking molecular/cell culture experiments, whole animal assays, human epidemiologic research, interventions, and policy; 2) integration of environment, social justice and health to understand vulnerability and resilience; 3) building bridges with communities, clinicians, and policy- makers. Layered on those broad themes, we continue to cultivate the historic UCD strengths in research on respiratory, nervous, immune, metabolic, endocrine, and reproductive systems, and recently expanded into cancer and climate-related health research. The Center has a Pilot Projects Program and four cores: Administration, Integrative Health Sciences, Exposure Sciences and Community Engagement, as well as various advisory committees. In the coming funding period, the UC Davis EHSC will expand its scope and impact by 1) advancing cutting-edge research in exposure characterization, environmental health effects, their molecular biologic mechanisms, and technology development for improving measurement of exposures and biomarkers; 2) enlarging the cadre of EHS researchers, and 3) engaging with policy-makers, community stakeholders and health professionals, to ensure relevance of our research and to translate findings into public health improvement. The Center emphasizes inter-disciplinary and translational approaches to environmental health issues and is developing partnerships with other Centers throughout UC Davis.

项目概要 - 总体加州大学戴维斯分校环境健康科学中心 (EHSC) 的使命是增进对环境引起的疾病和残疾，并将这些知识转化为干预措施、新的减少这些暴露或减轻其对健康影响的做法或政策变化。 EHSC 带来来自七所学校和学院从事环境健康科学（EHS）研究的教师一起跨越分子生物科学、环境科学、工程学、病理生理学、生物统计学、流行病学和社区发展，与人类状况相关。 EHSC 取得了巨大成就在不到 4 年的时间里取得了长足的进步。 EHSC 取得了显着的成就，其中包括：突破孤岛，将跨学科合作转变为我们成员之间的标准运作方式，吸引了新的和已建立的调查人员，并将环境健康置于其他中心的关注范围内整个加州大学戴维斯分校。 EHSC 成员越来越多地与社区利益相关者互动，并寻求解决社区驱动的问题。 EHSC 成就的几个亮点包括：1) 新颖的动物园使用从交通繁忙的隧道中抽出的实时空气进行空气污染健康研究的设施； 2）一个程序针对破坏性巨大的野火的暴露和健康影响的研究现已司空见惯整个美国西部； 3) 招募许多新的调查员，其中包括两名代表性不足的调查员少数民族妇女；在社交媒体上建立强大的影响力。由 NIEHS 指导 2018-2023 战略计划和 NIEHS 转化研究框架，我们采用了三个总体主题领域：1) 连接分子/细胞培养实验、整体动物分析的跨学科转化 EHS，人类流行病学研究、干预措施和政策； 2）环境、社会正义和健康以了解脆弱性和复原力； 3) 与社区、临床医生和政策建立桥梁- 制造商。基于这些广泛的主题，我们继续培养都柏林大学在研究方面的历史优势呼吸系统、神经系统、免疫系统、代谢系统、内分泌系统和生殖系统，最近又扩展到癌症和气候相关的健康研究。该中心有一个试点项目计划和四个核心：管理、综合健康科学、暴露科学和社区参与，以及各种咨询委员会。在接下来的资助期内，加州大学戴维斯分校 EHSC 将扩大其范围并 1) 推进暴露特征、环境健康影响及其影响方面的前沿研究分子生物学机制以及改善暴露测量的技术开发生物标志物； 2) 扩大 EHS 研究人员队伍，以及 3) 与政策制定者、社区接触利益相关者和卫生专业人员，以确保我们研究的相关性并将研究结果转化为公众健康改善。该中心强调环境问题的跨学科和转化方法健康问题，并正在与加州大学戴维斯分校的其他中心发展合作伙伴关系。