University of Minnesota Clinical and Translational Science Institute (UMN CTSI)

明尼苏达大学临床与转化科学研究所 (UMN CTSI)

• 批准号: 10763967
• 负责人: Bruce R Blazar
• 金额: $ 772.72万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2030-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10763967
• 关键词: Academia; Academy; Acceleration; Achievement; Address; Adoption; Advocate; African American; Attention; Award; Bioinformatics; Biometry; Black race; Child; Clinical Data; Clinical Research; Clinical Sciences; Collaborations; Communities; Community Health Aides; Community Medicine; Contracts; Data; Data Collection; Databases; Decision Making; Development; Diverse Workforce; Economics; Education; Electronic Health Record; Enrollment; Equity; Faculty; Fellowship; Fostering; Guidelines; Health; Health Information System; Health Policy; Health system; Healthcare; Incentives; Indigenous; Individual; Informatics; Information Systems; Informed Consent; Infrastructure; Institutional Racism; Investments; Knowledge; Latino; Leadership; Learning; Lesbian Gay Bisexual Transgender Queer; Link; Measures; Medical; Medicine; Mentored Clinical Scientist Development Program; Methodology; Methods; Minnesota; Modeling; Mothers; National Institute on Minority Health and Health Disparities; Nursery Schools; Participant; Pathway interactions; Patients; Personality Assessment; Population; Population Heterogeneity; Postdoctoral Fellow; Process; Public Health Informatics; Research; Research Design; Research Personnel; Research Support; Resource Allocation; Resources; Rural Health; Rural health equity; Science; Scientific Advances and Accomplishments; Series; Services; Strategic Planning; Structural Racism; Technology; Testing; Training; Training Activity; Transcend; Translational Research; Translations; Trust; Universities; Validation; Vietnamese; Work; anti-racism; career development; clinical implementation; cognitive function; community engaged research; community engagement; community partnership; cultural competence; data management; data sharing; early childhood; equity, diversity, and inclusion; experience; fetal methamphetamine exposure; health data; health equity; implementation science; improved; innovation; multidisciplinary; next generation; novel; programs; recruit; research data dissemination; research to practice; response; satisfaction; skills; success; tool; tribal Nation

Abstract. Clinical and translational science (CTS) is at the crossroads of major technology advances requiring academia-community partnerships anchored on trust for effective & rapid deployment of best practices. UMN CTSA Hub will build on proven commitments to accelerate impactful CTS. Aim 1 will provide novel infrastructure to reduce research barriers and accelerate translation to practice via a new Office of Clinical Research and Community Affairs to augment CTSI’s capacity to respond to and facilitate robust and sustainable community relationships transcending single investigator projects. Aim 2 will deliver high quality and efficient research services and resources via Clinical Research Support Center (85 staff) that will lessen trial barriers and support all aspects of study design, biostatistics, bioinformatics, regulatory compliance, contracts and more. Accelerating diversity, equity and inclusion progress will facilitate connectivity to our diverse population. A learning health system (LHS) and continuous quality improvement program will expedite implementation of novel enhancements. Aim 3 will cultivate and train a strong, diverse CTS workforce with new tools and programs; develop and test novel trial processes and participant satisfaction; then disseminate and implement learnings locally and nationally. Tailored enhancements will personalize CTS training for community, academic and workforce professionals, with attention to diversity, informed consent for non- English speakers, an investigator primer, research career development series and more. CTSI’s Rural Health Program offers an Equity Postdoctoral Fellowship and year-long community leader training in health policy & leadership. Cultural competency training will facilitate engagement with our multicultural community. Trained community health workers (CHWs) will advance research dissemination into practice and community. Aim 4 will foster leadership, team science and data sharing to support collaborations including leadership programs, professional coaching, vertically integrated retreats, team function seminars, Northern Leadership for Innovative Team Science program adapted for junior faculty and incentives to gain CTSI leadership skills. Health Informatics will support advanced data management, analytic infrastructures plus electronic health record & LHS information systems. Aim 5 strives for health equity and against structural racism by deploying an Equity Framework and antiracist research practices to train CHWs and Hub Partners for broad community input and decision-making. We will build a national population level geo-database of quantifiable measures of cultural and economic variables using a novel Multidimentional Measures of Systemic Racism Portal to link health and clinical data, define national impact of structural racism on study enrollment and data collection with a validation project on early childhood cognitive function after prenatal methamphetamine exposure. Impact. With a novel infrastructure, a diverse next generation of leaders and a well-trained diverse workforce, our Hub and regional community will co-develop and implement CTS advancements to improve health.

摘要：临床和转化科学（CTS）正处于重大技术进步的十字路口。 学术界与社区的伙伴关系以有效和快速部署 UMN 的信任为基础。 CTSA 中心将建立在经过验证的承诺之上，加速有影响力的 CTS 目标 1 将提供新颖的内容。 通过新的临床办公室减少研究障碍并加速转化为实践的基础设施 研究和社区事务，以增强 CTSI 响应和促进稳健和 超越单一研究者项目的可持续社区关系将提供高质量。 通过临床研究支持中心（85 名员工）提供高效的研究服务和资源，这将减少 试验试验并支持研究设计、生物统计学、生物信息学、法规遵从性的各个方面， 加速多元化、公平性和包容性的进步将促进我们的互联互通。 学习健康系统 (LHS) 和持续质量改进计划将加快人口多样化。 目标 3 的实施将培养和培训一支强大、多元化的 CTS 员工队伍。 新的工具和程序；开发和测试新颖的试验流程和参与者的满意度； 并在当地和全国范围内实施学习，定制增强措施将为 CTS 培训提供个性化服务。 社区、学术界和劳动力专业人士，关注多样性、非 讲英语的人、研究者入门书、研究职业发展系列等。 该计划提供公平博士后奖学金和为期一年的卫生政策和社区领袖培训 文化能力培训将促进与我们的多元文化社区的互动。 社区卫生工作者 (CHW) 将推动研究成果传播到实践和社区中，实现目标 4。 将培养领导力、团队科学和数据共享，以支持包括领导力项目在内的合作， 专业辅导、垂直整合务虚会、团队职能研讨会、北方领导力 适合初级教师的创新团队科学计划和获得 CTSI 领导技能的激励措施。 健康信息学将支持先进的数据管理、分析基​​础设施以及电子健康 目标 5 通过部署实现健康公平并反对结构性种族主义。 公平框架和反种族主义研究实践，为广大社区培训社区卫生工作者和中心合作伙伴 我们将建立一个国家人口层面的可量化措施的地理数据库。 使用新颖的系统性种族主义多维措施门户网站将文化和经济变量联系起来 健康和临床数据，定义结构性种族主义对研究注册和数据收集的国家影响 产前甲基苯丙胺暴露影响后儿童早期认知功能的验证项目。 我们的中心拥有新颖的基础设施、多元化的下一代领导者和训练有素的多元化员工队伍 和区域社区将共同开发和实施 CTS 进步，以改善健康。