A Dyadic Sleep Intervention for Alzheimers Disease Patients and Their Caregivers

针对阿尔茨海默病患者及其护理人员的二元睡眠干预

• 批准号: 9918212
• 负责人: Yeonsu Song
• 金额: $ 19.61万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-15 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9918212
• 关键词: Address; Admission activity; Advanced Practice Nurse; Aftercare; Alzheimer' s Disease; Alzheimer' s disease caregiver; Alzheimer' s disease patient; American; Area; Behavioral; Biological Markers; Biological Process; Board Certification; C-reactive protein; Capsicum; Cardiovascular system; Caregivers; Chronic Disease; Cognitive; Control Groups; Data; Dementia; Doctor of Philosophy; Education; Elderly; Event; Family Nursing; Fellowship; Focus Groups; Funding; Future; Gene Expression; Genomics; Geriatrics; Gerontology; Goals; Health; Health Care Costs; Healthcare Systems; Home visitation; Hour; Hypertension; Impaired cognition; Individual; Inflammation; Inflammatory; Institution; Institutionalization; Intervention; Intervention Studies; Knowledge; Los Angeles; Measures; Medicine; Mentors; Methods; Nature; Non-Insulin-Dependent Diabetes Mellitus; Nurse Practitioners; Nursing Homes; Outcome; Patient Care; Patients; Phase; Pilot Projects; Preparation; Public Health; Quality of Care; Quality of life; Randomized Controlled Trials; Recommendation; Research; Research Activity; Research Personnel; Research Training; Resources; Risk; Sleep; Sleep Disorders; Sleep disturbances; Stress; Structure; Techniques; Telephone; Testing; Time; Training; United States National Institutes of Health; Veterans; Work; actigraphy; base; career development; caregiver interventions; clinical center; community setting; compression therapy; economic value; educational atmosphere; experience; follow-up; improved; improvement on sleep; inflammatory marker; informal caregiver; innovation; interest; intervention effect; intervention program; medical schools; meetings; member; mortality risk; novel; prevent; primary outcome; professor; programs; skills; sleep health; sleep quality; trial design; usability

Project Summary/Abstract Yeonsu Song, PhD, RN, FNP-C is an Assistant Professor at the David Geffen School of Medicine at UCLA and is fully committed to becoming an independently-funded investigator specializing in sleep in individuals with cognitive impairments such as Alzheimer’s disease (AD) and their caregivers. She has a particular interest in testing a dyadic sleep intervention program for Alzheimer’s disease patients and their informal caregivers. Dr. Song’s unique background makes her an ideal candidate for this field of research. She has fellowship training in advanced geriatrics, and has board certification in advanced practice nursing as a family nurse practitioner. She is currently supported by an Advanced Fellowship in Geriatrics through the Veterans Affairs (VA) Greater Los Angeles Healthcare System, Geriatric Research, Education, and Clinical Center (GRECC). Career development and training plan: This plan features an outstanding research and educational environment at UCLA, with nationally renowned expert mentors. Her primary mentoring team is comprised of Drs. Jennifer Martin (expert in behavioral sleep interventions), Cathy Alessi (expert in sleep medicine), Michael Irwin (expert in inflammatory factors and sleep), and Edmond Teng (expert in assessment of AD). She will also draw on resources available through UCLA’s CTSI, UCLA’s Multicampus Program in Geriatric Medicine and Gerontology, UCLA’s Claude D. Pepper Center, and the GRECC. Her training plan features carefully curated coursework and hands-on training experiences, all aligned with her training goals. Research plan: The proposed research is hypothesis-driven and guided by preliminary data from Dr. Song’s VA-funded pilot study and existing behavioral sleep intervention methods. During the past 2 years of her fellowship, she has developed a dyadic sleep intervention program. In phase 1 (Aim 1), she will iteratively refine and finalize the intervention program targeting both members of the dyad (patients and caregivers) by evaluating acceptability and usability. In phase 2 (Aims 2-4) she will pilot test the program effects by assessing sleep, health, and quality of life in both members of the group using a small randomized controlled trial design, with the main analyses focused on caregiver outcomes. The intervention program will involve five sessions, including 4 home visits and one telephone session. It will include manualized sleep hygiene recommendations and a behavioral sleep intervention including sleep compression therapy. A unique aspect of the proposed work is that the program is tailored to address sleep problems of both patients and caregivers, and includes upstream biomarkers to evaluate a key mechanism of intervention benefits that can be further explored in future research. Skills developed from executing this training and research plan will enable Dr. Song to become an independent researcher and a leader in research on managing sleep in AD patients and their caregivers, with the goal of improving their health and quality of life.

项目概要/摘要 Yeonsu Song，博士、注册护士、FNP-C 是加州大学洛杉矶分校大卫格芬医学院的助理教授， 完全致力于成为一名独立资助的研究者，专门研究患有以下疾病的个体的睡眠 她对阿尔茨海默病 (AD) 等认知障碍及其护理人员特别感兴趣。 测试针对阿尔茨海默病患者及其非正式护理人员的二元睡眠干预计划。 宋的独特背景使她成为该研究领域的理想人选。她接受过奖学金培训。 拥有高级老年病学博士学位，并拥有家庭执业护士高级实践护理委员会认证。 她目前通过退伍军人事务部 (VA) 大区获得老年病学高级奖学金的支持 洛杉矶医疗系统、老年研究、教育和临床中心 (GRECC)。 职业发展和培训计划：该计划具有出色的研究和教育特色 她的主要导师团队由加州大学洛杉矶分校的环境和全国知名的专家导师组成。 Jennifer Martin 博士（行为睡眠干预专家）、Cathy Alessi（睡眠医学专家）、Michael Irwin（炎症因子和睡眠专家）和 Edmond Teng（AD 评估专家）她也会。 利用加州大学洛杉矶分校的 CTSI、加州大学洛杉矶分校老年医学多校区项目提供的资源， 老年学、加州大学洛杉矶分校克劳德·D·佩珀中心和 GRECC 她的培训计划经过精心策划。 课程作业和实践培训经验，所有这些都与她的培训目标一致。 研究计划：拟议的研究以假设为驱动，并以宋博士的初步数据为指导 VA 资助的试点研究和她过去两年的现有行为睡眠干预方法。 在奖学金中，她制定了一个二元睡眠干预计划，在第一阶段（目标 1），她将迭代地进行。 完善并最终确定针对二人组成员（患者和护理人员）的干预计划： 在第二阶段（目标 2-4）中，她将通过评估来试点测试计划效果。 使用小型随机对照试验设计研究小组两名成员的睡眠、健康和生活质量， 主要分析集中在护理人员的结果上，干预计划将涉及五次会议， 包括 4 次家访和 1 次电话会议，其中包括手动睡眠卫生建议。 以及行为睡眠干预，包括睡眠加压疗法。 该计划的工作重点是解决患者和护理人员的睡眠问题，包括 上游生物标志物来评估干预效益的关键机制，可以进一步探索 通过执行该培训和研究计划而开发的技能将使宋博士能够 成为 AD 患者及其睡眠管理研究的独立研究者和领导者 护理人员，以改善他们的健康和生活质量为目标。