Central Effects of Acupuncture: Acupoint Specificity

针灸的中枢作用：穴位特异性

• 批准号: 7559980
• 负责人: JI L FANG
• 金额: $ 3.2万
• 依托单位: GUANG AN MEN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-05 至 2009-12-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7559980
• 关键词: Acupuncture Points; Acupuncture procedure; Adult; Area; Biometry; Brain; Brain Mapping; China; Chinese Traditional Medicine; Clinical; Clinical Treatment; Collaborations; Country; Coupled; Data; Data Analyses; Doctor of Medicine; Doctor of Philosophy; Elbow; Electroacupuncture; Face; Fellowship; Functional Magnetic Resonance Imaging; General Hospitals; Goals; Guidelines; Home environment; Hospitals; Human; Image; Individual; Institutes; Knowledge; Leg; Limbic System; Massachusetts; Mentorship; Meridians; Methods; Names; Nerve Fibers; Neurosciences; Pattern; Preparation; Process; Publications; Research; Research Personnel; Resources; Rest; Route; Science; Signal Transduction; Specificity; Spinal Cord; Supervision; Technology; Testing; Training; Visit; Work; base; bioimaging; computerized data processing; design; experience; hemodynamics; insight; medical schools; nerve supply; neuroimaging; neuromechanism; neurophysiology; programs; receptor density; relating to nervous system; response; skills; theories

The purpose of this study is to use fMRI to investigate whether the brain response to acupuncture depends primarily on the meridian origin or on the segmental innervations of the acupoint. Whether different acupoints exert effects that are distinct from one another (acupoint specificity) is an important but unsettled issue in acupuncture theory and practice. In this study the acupoint specificity is tested in 18 healthy adults by comparing two acupoints of different meridians and a sham point, all of which are in the same neural segment, and a fourth acupoint that differs both in meridian and in segmental innervarions from the acupoints above. Whole brain fMRI is performed during electroacupuncture at St36 (Zusanli),Gb34 (Yanglingquan) and a sham point on the leg, and at Li11(Quchi) on the elbow. The fMRI data are analyzed to identify regions that may be activated or deactivated, and to quanity the signal changes. The hemodynamic response will be corelated with the meridian and segmental innervations of the acupoints. My long-term goal is to find more evidence to elucidate the central neurophysiological mechanism of acupoint specificity. This will help provide a scientific guideline for the selection of acupoints in clinical PHS 416-1 (Rev. 06/02) Page 2 Number pages consecutivelyat the bottomthroughout (Form Page 2) the application. Do not use suffixes such as 2a, 2b. NAME OF APPLICANT (Last, first, middle initial) Kirschstein-NRSA Individual Fellowship Application Fang.Jiliang Continuation Page Item 18to continue Dr. Kathleen K.S. Hui is a pioneer in the application of fMRI to study the acupuncture effects on human brain. She works closely with Kenneth Kwong.Ph.D., Jing liu, Lie Ac, and Bruce Rosen, M.D., Ph.D and a team of interdisciplinary experts in an enviroment with exceptional imaging facilities at the Martinos Center for Biomedical Imaging (hereafter referred to as "the Center") of Massachusetts General Hospital (MGH). Their findings have potential significance and may contribute new insight into the neuromechanisms of acupuncture. I am confident that the fellowship training under their supervision and mentorship will provide me with the skills and knowledge for the successful application of fMRI in acupuncture research in my home country. The following are the areas that I propose for my trainiing. 1. Training and working experience by participating in Dr. Hui's ongoing acupuncture projects at the Center. 2. Complete a small independent pilot plot in acupuncture/fMRI under the supervision and mentorship of Dr. Hui and Dr. Kwong. 3. Attend courses of neuroimaging, neuroscience, biostatistics, etc offered by MGH, Harvard Medical School and Massachusetts Institute of Technology; participate in the intensive courses designed for visiting fellows and the weekly Human Brain Mapping seminars at the Center. 4.Understand more thoroughly the principles of fMRI and master a method that is best suited for processing acupuncture fMRI data. Several established data processing programs (AFNI,SPM, FSL and Freesurfer, etc)are being used or tested at the Center. Attempts are being made to integrate useful features from different programs for acupuncture fMRI data processing. 5.Further my knowledge in neuroscience, focusing on brain functions, functional connectivity especially the relationships of the limbic system with the rest of the brain. After finishing this training, I shall return to China to continue using neuroimaging in acupuncture research. I shall work in close collaboration with Dr. Hui's group at the Center. We shall bring together the clinical resources and experiences in Traditional Chinese Medicine (TCM)at my hospital and the science and technology at the MGH imaging center. Kirschstein-NRSA Individual Fellowship Application NAME OFAPPLICANT (Last, first, middle initial) Fang.Jiliang Table of Contents Page Numbers (Number pagas consecutively at the bottom throughout the application. Section 1¿ Applicant Do not use suffixes such as 6a, 6b.) Face Page (Items 1-8,15), Page 2 (Items 16-18, 22), and Table of Contents (Form Page 3) 1-4 Scholastic

这项研究的目的是使用fMRI研究大脑对针灸的反应是否依赖 首先在子午线或穴位的分段神经上。是否与众不同 穴位执行彼此不同的效果（穴位特异性）是一个重要但尚未确定的 针灸理论和实践中的问题。在这项研究中，在18位健康成年人中测试了兆头特异性 通过比较不同的子午线和假点的两个穴位，所有这些都处于同一神经中 段，以及在子午线和分段内膜中不同的第四个穴位 上面的穴位。全脑fMRI在ST36（Zusanli）的电针中进行，GB34 （Yanglingquan）和腿上的假点，在肘部的Li11（Quchi）上。分析fMRI数据 识别可能被激活或停用的区域，并消除信号的变化。 血液动力学反应将与穴位的子午线和分段神经加在一起。 我的长期目标是找到更多证据，以阐明 穴位特异性。这将有助于为选择临床的晋升提供科学指南 PHS 416-1（修订版06/02）第2页数字页面保守底部（表2） 应用程序。请勿使用后缀2a，2b。 申请人的名称（最后，第一个，中间缩写） Kirschstein-NRSA个人奖学金申请 Fang.jiliang 延续页面 第18项继续 Kathleen K.S.博士HUI是fMRI应用针灸对对针灸的影响的先驱 人脑。她与Kenneth Kwong.ph.d.，Jing Liu，Lie AC和Bruce Rosen紧密合作， 医学博士，博士学位和一个跨学科专家团队，在具有出色成像的环境中 马提尼斯生物医学成像中心（以下称为“中心”）的设施 马萨诸塞州综合医院（MGH）。他们的发现具有潜在的意义，可能 对针灸的神经力学有了新的见解。我有信心奖学金 在他们的监督和指导方面的培训将为我提供技能和知识 在我的祖国，fMRI成功地应用了针灸研究。以下是 我建议培训的领域。 1。通过参加Hui博士正在进行的针灸项目的培训和工作经验 中心。 2。在监督下完成针灸/fMRI中的一个小型独立飞行员地块， Hui博士和Kwong博士的遗产。 3。参加MGH，哈佛提供的神经影像学，神经科学，生物统计学等课程 医学院和马萨诸塞州理工学院；参加密集课程 专为参观研究员和中心的每周人脑映射半射手而设计。 4.更彻底地理解fMRI和掌握一种最适合的方法 处理针灸fMRI数据。几个已建立的数据处理程序（AFNI，SPM， FSL 在中心使用或测试了FreeSurfer等）。正在尝试整合 针灸fMRI数据处理的不同程序的有用功能。 5。进一步的我对神经科学的了解，专注于大脑功能，功能连通性 特别是边缘系统与大脑其余部分的关系。 完成这项培训后，我将回到中国继续使用针灸中的神经影像 研究。我将与中心的Hui博士小组密切合作。我们将带来 在我的 医院以及MGH成像中心的科学技术。 Kirschstein-nrsa个人奖学金应用程序名称Applicant的名称（最后，第一个，中间缩写） Fang.jiliang 目录 页码 （保守的帕加斯在 整个应用程序中的底部。 第1节申请人 请勿使用后缀6a，6b。） 面页（项目1-8,15），第2页（项目16-18，22）和目录（表3）1-4 学术

项目成果

White matter abnormalities in major depression: a tract-based spatial statistics and rumination study.

• DOI: 10.1371/journal.pone.0037561
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Zuo N;Fang J;Lv X;Zhou Y;Hong Y;Li T;Tong H;Wang X;Wang W;Jiang T
• 通讯作者: Jiang T

The Limbic-Prefrontal Network Modulated by Electroacupuncture at CV4 and CV12.

• DOI: 10.1155/2012/515893
• 发表时间: 2012
• 期刊: Evidence-based complementary and alternative medicine : eCAM
• 作者: Fang J;Wang X;Liu H;Wang Y;Zhou K;Hong Y;Liu J;Wang L;Xue C;Song M;Liu B;Zhu B
• 通讯作者: Zhu B