Central Effects of Acupuncture: Acupoint Specificity

针灸的中枢作用：穴位特异性

• 批准号: 7559980
• 负责人: JI L FANG
• 金额: $ 3.2万
• 依托单位: GUANG AN MEN HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-05 至 2009-12-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7559980
• 关键词: Acupuncture Points; Acupuncture procedure; Adult; Area; Biometry; Brain; Brain Mapping; China; Chinese Traditional Medicine; Clinical; Clinical Treatment; Collaborations; Country; Coupled; Data; Data Analyses; Doctor of Medicine; Doctor of Philosophy; Elbow; Electroacupuncture; Face; Fellowship; Functional Magnetic Resonance Imaging; General Hospitals; Goals; Guidelines; Home environment; Hospitals; Human; Image; Individual; Institutes; Knowledge; Leg; Limbic System; Massachusetts; Mentorship; Meridians; Methods; Names; Nerve Fibers; Neurosciences; Pattern; Preparation; Process; Publications; Research; Research Personnel; Resources; Rest; Route; Science; Signal Transduction; Specificity; Spinal Cord; Supervision; Technology; Testing; Training; Visit; Work; base; bioimaging; computerized data processing; design; experience; hemodynamics; insight; medical schools; nerve supply; neuroimaging; neuromechanism; neurophysiology; programs; receptor density; relating to nervous system; response; skills; theories

The purpose of this study is to use fMRI to investigate whether the brain response to acupuncture depends primarily on the meridian origin or on the segmental innervations of the acupoint. Whether different acupoints exert effects that are distinct from one another (acupoint specificity) is an important but unsettled issue in acupuncture theory and practice. In this study the acupoint specificity is tested in 18 healthy adults by comparing two acupoints of different meridians and a sham point, all of which are in the same neural segment, and a fourth acupoint that differs both in meridian and in segmental innervarions from the acupoints above. Whole brain fMRI is performed during electroacupuncture at St36 (Zusanli),Gb34 (Yanglingquan) and a sham point on the leg, and at Li11(Quchi) on the elbow. The fMRI data are analyzed to identify regions that may be activated or deactivated, and to quanity the signal changes. The hemodynamic response will be corelated with the meridian and segmental innervations of the acupoints. My long-term goal is to find more evidence to elucidate the central neurophysiological mechanism of acupoint specificity. This will help provide a scientific guideline for the selection of acupoints in clinical PHS 416-1 (Rev. 06/02) Page 2 Number pages consecutivelyat the bottomthroughout (Form Page 2) the application. Do not use suffixes such as 2a, 2b. NAME OF APPLICANT (Last, first, middle initial) Kirschstein-NRSA Individual Fellowship Application Fang.Jiliang Continuation Page Item 18to continue Dr. Kathleen K.S. Hui is a pioneer in the application of fMRI to study the acupuncture effects on human brain. She works closely with Kenneth Kwong.Ph.D., Jing liu, Lie Ac, and Bruce Rosen, M.D., Ph.D and a team of interdisciplinary experts in an enviroment with exceptional imaging facilities at the Martinos Center for Biomedical Imaging (hereafter referred to as "the Center") of Massachusetts General Hospital (MGH). Their findings have potential significance and may contribute new insight into the neuromechanisms of acupuncture. I am confident that the fellowship training under their supervision and mentorship will provide me with the skills and knowledge for the successful application of fMRI in acupuncture research in my home country. The following are the areas that I propose for my trainiing. 1. Training and working experience by participating in Dr. Hui's ongoing acupuncture projects at the Center. 2. Complete a small independent pilot plot in acupuncture/fMRI under the supervision and mentorship of Dr. Hui and Dr. Kwong. 3. Attend courses of neuroimaging, neuroscience, biostatistics, etc offered by MGH, Harvard Medical School and Massachusetts Institute of Technology; participate in the intensive courses designed for visiting fellows and the weekly Human Brain Mapping seminars at the Center. 4.Understand more thoroughly the principles of fMRI and master a method that is best suited for processing acupuncture fMRI data. Several established data processing programs (AFNI,SPM, FSL and Freesurfer, etc)are being used or tested at the Center. Attempts are being made to integrate useful features from different programs for acupuncture fMRI data processing. 5.Further my knowledge in neuroscience, focusing on brain functions, functional connectivity especially the relationships of the limbic system with the rest of the brain. After finishing this training, I shall return to China to continue using neuroimaging in acupuncture research. I shall work in close collaboration with Dr. Hui's group at the Center. We shall bring together the clinical resources and experiences in Traditional Chinese Medicine (TCM)at my hospital and the science and technology at the MGH imaging center. Kirschstein-NRSA Individual Fellowship Application NAME OFAPPLICANT (Last, first, middle initial) Fang.Jiliang Table of Contents Page Numbers (Number pagas consecutively at the bottom throughout the application. Section 1¿ Applicant Do not use suffixes such as 6a, 6b.) Face Page (Items 1-8,15), Page 2 (Items 16-18, 22), and Table of Contents (Form Page 3) 1-4 Scholastic

本研究的目的是利用功能磁共振成像来研究大脑对针灸的反应是否取决于 主要看经络的起源还是穴位的节段神经支配是否不同。 穴位发挥的作用各不相同（穴位特异性）是一个重要但尚未解决的问题 针灸理论和实践中的问题 本研究在 18 名健康成年人中测试了穴位特异性。 通过比较不同经络的两个穴位和一个假穴，所有这些穴位都处于同一神经网络 节段，以及第四个穴位，其经络和节段内在变化都与 上述穴位在电针St36（足三里）、Gb34时进行全脑功能磁共振成像。 对腿部的阳陵泉和假穴以及肘部的曲池进行功能磁共振成像数据分析。 识别可能被激活或停用的区域，并对信号变化进行量化。 血流动力学反应与腧穴的经络和节段神经支配有关。 我的长期目标是找到更多证据来阐明中枢神经生理机制 为临床选穴提供科学指导。 PHS 416-1 (Rev. 06/02) 第 2 页 在整个底部连续编号页码（表格第 2 页） 请勿使用 2a、2b 等后缀。 申请人姓名（姓氏、名字、中间名首字母） Kirschstein-NRSA 个人奖学金申请 方继良 续页 第 18 项继续 Kathleen K.S. Hui 博士是应用功能磁共振成像研究针灸疗效的先驱 她与 Kenneth Kwong.Ph.D.、Jing liu、Lie Ac 和 Bruce Rosen 密切合作， 医学博士、博士和跨学科专家团队在卓越成像环境中 马蒂诺斯生物医学成像中心（以下简称“中心”）的设施 马萨诸塞州总医院（MGH）的研究结果具有潜在意义，可能会产生潜在的影响。 我相信该奖学金将为针灸的神经机制提供新的见解。 在他们的监督和指导下进行的培训将为我提供以下技能和知识： 我国fMRI在针灸研究中的成功应用如下。 我建议进行培训的领域。 1. 参加许医生正在进行的针灸项目的培训和工作经验 中心。 2. 在监督下完成针灸/功能磁共振成像的小型独立试点 许博士及邝博士的指导。 3. 参加麻省总医院、哈佛大学神经影像、神经科学、生物统计学等课程 医学院和麻省理工学院参加强化课程； 专为访问学者和中心每周举行的人脑图谱研讨会而设计。 4.更深入地理解fMRI原理，掌握最适合的方法 处理针灸功能磁共振成像数据。几个已建立的数据处理程序（AFNI，SPM， FSL 和Freesurfer等）正在中心使用或测试。 来自针灸功能磁共振成像数据处理的不同程序的有用功能。 5.进一步加深我在神经科学方面的知识，重点关注大脑功能、功能连接 尤其是边缘系统与大脑其他部分的关系。 完成本次培训后，我将返回中国继续在针灸中使用神经影像学 我将与中心的许博士团队密切合作。 汇集了我院的中医临床资源和经验 医院和 MGH 影像中心的科学技术。 Kirschstein-NRSA 个人奖学金申请 申请人姓名（姓氏、名字、中间名首字母） 方继良 目录 页码 （在 整个应用程序的底部。 第 1 节申请人 （请勿使用 6a、6b 等后缀。） 正面页（第 1-8,15 项）、第 2 页（第 16-18、22 项）和目录（表格第 3 页）1-4 学术的

项目成果

White matter abnormalities in major depression: a tract-based spatial statistics and rumination study.

• DOI: 10.1371/journal.pone.0037561
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Zuo N;Fang J;Lv X;Zhou Y;Hong Y;Li T;Tong H;Wang X;Wang W;Jiang T
• 通讯作者: Jiang T

The Limbic-Prefrontal Network Modulated by Electroacupuncture at CV4 and CV12.

• DOI: 10.1155/2012/515893
• 发表时间: 2012
• 期刊: Evidence-based complementary and alternative medicine : eCAM
• 作者: Fang J;Wang X;Liu H;Wang Y;Zhou K;Hong Y;Liu J;Wang L;Xue C;Song M;Liu B;Zhu B
• 通讯作者: Zhu B