ORAL CANDIDA

口腔念珠菌

• 批准号: 7719112
• 负责人: Anna I Dongari-Bagtzoglou
• 金额: $ 0.83万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719112
• 关键词: Antifungal Agents; Candida; Cells; Computer Retrieval of Information on Scientific Projects Database; Epithelial Cells; Funding; Grant; Immune; Immunocompromised Host; Institution; Neutrophil Activation; Opportunistic Infections; Oral; Oral candidiasis; Proteins; Purpose; Research; Research Personnel; Resistance; Resources; Source; Testing; United States National Institutes of Health; cell type; cytokine; fungus; neutrophil; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Oral candidiasis is perhaps the most frequent opportunistic infection associated with an immunocompromised host. The most important immune cell type in the defense against Candida is the neutrophil (PMN). Although these cells are considered important in the resistance to and eradication of fungi, expression of these functions requires activation by soluble proteins known as cytokines. In the immunocompromised host these molecules are more likely to be derived from cells of non-immune origin, such as epithelial cells. The purpose of this study is to test the activation of neutrophil anti-fungal functions in response to cytokines secreted by oral epithelial cells.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 口服念珠菌病也许是与免疫功能低下宿主相关的最常见机会感染。防御念珠菌中最重要的免疫细胞类型是中性粒细胞（PMN）。尽管这些细胞在对真菌的抗性和消除中被认为很重要，但这些功能的表达需要可溶性蛋白质被称为细胞因子的蛋白质。在免疫功能低下的宿主中，这些分子更有可能源自非免疫起源细胞，例如上皮细胞。这项研究的目的是测试响应口腔上皮细胞分泌的细胞因子的中性粒细胞抗真菌功能的激活。