Cardiovascular Imaging in Ischemic Heart Disease

缺血性心脏病的心血管成像

基本信息

批准号：
9914877
负责人：
UDO HOFFMANN
金额：
$ 12.09万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-01 至 2021-03-01
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9914877
关键词：
Achievement Acute Address Age Antiinflammatory Effect Area Blood Vessels Cardiac Cardiology Cardiovascular system Case-Control Studies Charge Chest Pain Clinical Clinical Data Clinical Investigator Clinical Research Clinical/Radiologic Coronary Coronary Arteriosclerosis Data Environment Epidemiology Evaluation Studies Event Faculty Foundations Framingham Heart Study Funding Future Goals Grant HIV Journals Machine Learning Measurement Measures Medical Mentors Mid-Career Clinical Scientist Award (K24)Myocardial Ischemia National Heart, Lung, and Blood Institute Natural History Outcome Outcomes Research Paper Participant Patients Peer Review Peer Review Grants Placebos Population Positioning Attribute Positron-Emission Tomography Public Health Schools Publications Publishing Radiology Specialty Randomized Randomized Controlled Trials Research Research Methodology Research Personnel Research Project Grants Research Support Risk stratification Syndrome Techniques Testing Time Training Programs Translational Research United States National Institutes of Health base cardiovascular imaging career comparative effectiveness trial coronary plaque cost cost effectiveness experience follow-up high risk imaging biomarker imaging study improved indexing innovation markov model medical schools member novel patient oriented research predictive marker prevent professor programs prospective radiomics randomized trial repository sex skills synergism training opportunity

项目摘要

Project Summary/Abstract The applicant Udo Hoffmann MD MPH is a Professor of Radiology at Harvard Medical School and the Chief of the Division for Cardiovascular Imaging in the Department of Radiology at MGH. Dr. Hoffmann has established a patient oriented research (POR) program that combines innovative translational, clinical, and outcomes research methods to demonstrate the value of advanced cardiovascular imaging. Dr. Hoffmann has published approximately 380 peer reviewed papers, among them many in premier medical journals and has received continued independent, peer-reviewed POR NIH funding since 2005. He is among the very few faculty members at Harvard Medical School who are both the PI and Director of a highly successful NHLBI funded T- 32 program (Cardiac MR and CT Research) and a recipient of a K24. Dr. Hoffmann has successfully mentored more than 60 clinical investigators, most of which currently hold faculty positions in major academic centers and actively perform POR. Moreover, Dr. Hoffmann has successfully accomplished all mentoring and scientific goals of the first K24 award period. Overall, these achievements document Dr. Hoffmann's long standing passion and commitment to POR. His excellent publication, funding, and mentoring record together with his current and planned research support provide an excellent foundation to accomplish the aims of this competitive renewal of the K24 Award “Cardiovascular Imaging in Ischemic Heart Disease”. Dr. Hoffmann proposes a mentoring and research plan that utilizes the synergies of past, ongoing, and future highly innovative independent research projects with educational and training opportunities offered by the cardiac MR CT PET Program, the T32 training program in cardiovascular imaging, the Harvard CTSA, and the Harvard School of Public Health. The specific aims addressing the charge of the K24 Award are to enable Dr. Hoffmann to: 1) dedicate 25% of his time to mentor clinical investigators based on NIH or equivalent funded projects in “Cardiovascular Imaging in Ischemic Heart Disease”, 2) to mentor junior and mid-career clinical investigators with the goal to develop them into clinical researchers who can successfully compete for peer reviewed grants, and 3) to continue to expand a POR program that combines translational, clinical, and outcomes research to develop future leaders in clinical research in cardiovascular imaging and beyond. The research plan encompasses four specific aims: 1) To determine the effects of statin treatment on coronary atherosclerosis in HIV patients in 800 patients with HIV randomized to statin therapy vs. placebo, 2) To determine whether high risk coronary plaque predicts cardiovascular events in 4600 patients with clinical suspicion of CAD, 3) To determine the cost effectiveness of CT FFR in patients with stable and acute chest pain, and 4) To use Radiomics to identify novel imaging markers predicting cardiovascular events in participants of the Framingham Heart Study.

项目概要/摘要申请人 Udo Hoffmann MD MPH 是哈佛医学院放射学教授，也是 Hoffmann 博士在麻省总医院放射科设立了心血管影像科。以患者为导向的研究 (POR) 计划，结合创新的转化、临床和结果霍夫曼博士发表了证明先进心血管成像价值的研究方法。约 380 篇同行评审论文，其中许多发表在顶级医学期刊上，并已获得自 2005 年以来，他持续获得独立、经过同行评审的 POR NIH 资助。他是极少数的教师之一哈佛医学院的成员，他们是 NHLBI 资助的一个非常成功的 T-项目的 PI 和主任 Hoffmann 博士成功指导了 32 个项目（心脏 MR 和 CT 研究）和 K24 的获得者。 60多名临床研究人员，其中大多数目前在主要学术中心担任教职此外，霍夫曼博士还成功地完成了所有指导和科学工作。总体而言，这些成就记录了霍夫曼博士的长期成就。他对 POR 的热情和承诺以及出色的出版物、资助和指导记录。当前和计划中的研究支持为实现本目标提供了良好的基础霍夫曼博士竞争性更新 K24 奖“缺血性心脏病的心血管成像”。提出一项指导和研究计划，充分利用过去、正在进行和未来的协同作用心脏 MR 提供的创新独立研究项目以及教育和培训机会 CT PET 计划、心血管影像 T32 培训计划、哈佛 CTSA 和哈佛公共卫生学院。解决 K24 奖的具体目标是使霍夫曼博士能够获得支持。 1) 投入 25% 的时间指导 NIH 或同等资助项目的临床研究人员 “缺血性心脏病的心血管成像”，2) 指导初级和中期临床研究人员目标是将他们培养成能够成功竞争同行评审资助的临床研究人员， 3) 继续扩展 POR 计划，将转化、临床和结果研究结合起来培养心血管成像及其他领域临床研究的未来领导者。包含四个具体目标： 1) 确定他汀类药物治疗对冠状动脉粥样硬化的影响 HIV 患者中的 800 名 HIV 患者随机接受他汀类药物治疗与安慰剂，2) 确定是否高冠状动脉风险斑块可预测 4600 名临床怀疑患有 CAD 的患者的心血管事件，3) 确定 CT FFR 对稳定型和急性胸痛患者的成本效益，以及 4) 使用放射组学识别预测参与者心血管事件的新型成像标志物弗雷明汉心脏研究。

项目成果

期刊论文数量（24）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Fat quality and incident cardiovascular disease, all-cause mortality, and cancer mortality.

脂肪质量和心血管疾病事件、全因死亡率和癌症死亡率。

DOI：
10.1210/jc.2013-4296
发表时间：
2024-09-14
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
0
作者：
Klara J. Rosenquist;J. Massaro;Alison Pedley;M. Long;B. Kreger;R. Vasan;J. Murabito;U. Hoffmann;C. Fox
通讯作者：
C. Fox

Quantitative coronary computed tomography angiography for the detection of cardiac allograft vasculopathy.

定量冠状动脉计算机断层扫描血管造影用于检测心脏同种异体移植血管病变。

DOI：
发表时间：
2020-08
期刊：
影响因子：
5.9
作者：
Foldyna, Borek;Sandri, Marcus;Luecke, Christian;Garbade, Jens;Gohmann, Robin;Hahn, Jochen;Fischer, Julia;Gutberlet, Matthias;Lehmkuhl, Lukas
通讯作者：
Lehmkuhl, Lukas

Erratum to: Outcomes of anatomical vs. functional testing for coronary artery disease : Lessons from the major trials.

勘误表：冠状动脉疾病的解剖与功能测试的结果：主要试验的教训。

DOI：
发表时间：
2020-08
期刊：
影响因子：
1.7
作者：
Karády, Júlia;Taron, Jana;Kammerlander, Andreas Anselm;Hoffmann, Udo
通讯作者：
Hoffmann, Udo

Imaging methods for detection of chemotherapy-associated cardiotoxicity and dysfunction.

用于检测化疗相关心脏毒性和功能障碍的成像方法。

DOI：
发表时间：
2014-04
期刊：
影响因子：
0
作者：
Ong, Daniel S;Scherrer;Coelho;Francis, Sanjeev A;Neilan, Tomas G
通讯作者：
Neilan, Tomas G

PROspective Multicenter Imaging Study for Evaluation of chest pain: rationale and design of the PROMISE trial.

评估胸痛的前瞻性多中心影像研究：PROMISE 试验的基本原理和设计。

DOI：
发表时间：
2014-06
期刊：
影响因子：
4.8
作者：
Douglas, Pamela S;Hoffmann, Udo;Lee, Kerry L;Mark, Daniel B;Al;Anstrom, Kevin;Dolor, Rowena J;Kosinski, Andrzej;Krucoff, Mitchell W;Mudrick, Daniel W;Patel, Manesh R;Picard, Michael H;Udelson, James E;Velazquez, Eric J;Coo
通讯作者：
Coo