MINORITY-BASED COMMUNITY ONCOLOGY PROGRAM

基于少数民族的社区肿瘤学计划

• 批准号: 10680599
• 负责人: Balazs Halmos
• 金额: $ 92.94万
• 依托单位: MONTEFIORE MEDICAL CENTER (BRONX, NY)
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10680599
• 关键词: Academic Medical Centers; Address; Adjuvant; Adjuvant Study; Advanced Malignant Neoplasm; Aftercare; Albert Einstein Cancer Center; American College of Radiology Imaging Network; Anal carcinoma; Area; Biological Markers; Black race; Breast Cancer Detection; Cancer Center; Cancer Control; Cancer Patient; Clinical; Clinical Research; Collection; Committee Members; Communities; Community Clinical Oncology Program; County; Coupled; Diagnosis; Doctor of Philosophy; Eastern Cooperative Oncology Group; Ethnic Origin; Evaluation; Faculty; Foundations; Funding; Goals; Health system; Hematopoietic Neoplasms; Hispanic; Home; Infrastructure; Institution; Language; Leadership; Malignant Neoplasms; Measurement; Medical center; Medicine; Mentored Clinical Scientist Development Program; Mentors; Methodology; Methods; Minority; Minority Groups; Minority Participation; Mission; Morbidity - disease rate; NCI-Designated Cancer Center; Neuropathy; New York; Nivolumab; Outcome; Outcomes Research; Patient Care; Patients; Pilot Projects; Prevention; Protocols documentation; Recording of previous events; Research; Research Personnel; Resources; Role; Science; Site; System; Therapeutic; Therapeutic Trials; Training; Training Programs; Training Support; Training and Education; Translational Research; Underrepresented Minority; United States; Urban Community; anticancer research; base; biomarker validation; black women; cancer care; cancer clinical trial; cancer health disparity; cancer imaging; cancer prevention; cancer therapy; care delivery; career; college; experience; federal poverty level; financial toxicity; health care delivery; health related quality of life; innovation; institutional capacity; malignant breast neoplasm; member; minority engagement; minority patient; minority subjects; mortality; novel; oncology program; patient engagement; population based; postgraduate education; precision medicine; programs; prospective; screening; success; taxane; team-based care; treatment trial; trial design; trial planning; underserved community; underserved minority

The overall goals of the Montefiore-Einstein minority-based NCORP community site are to advance the diagnosis, prevention, and management of early and advanced cancer by participating in NCORP trials as a minority/underserved community site, and contributing scientifically and administratively to the NCORP research bases. This will be accomplished by leveraging the strengths of the Montefiore Health System (MHS), including Montefiore Medical Center (MMC), which brings strengths in integrated patient care and innovative health care delivery systems in an academic medical center serving a largely minority population, and the Albert Einstein College of Medicine and Cancer Center (Einstein), which brings strength in training and education, and in baslc, translational, and clinical research through its NCI- designated cancer center. The MMC-Einstein program also brings critical leadership to the NCORP Research Bases, including ECOG-ACRIN, Alliance, and NRG, including leadership roles at the level of the group chair's office, scientific committee chair (or co-chair), and protocol chair (or co-chair). Our plans build upon our long-standing involvement in all aspects of cancer research as a main member of ECOG for 45 years and an NCI-designated cancer center for 48 years, and a strong history of minority accrual to cancer treatment trials (about 65%of all patients). MMC serves the Bronx, an urban community of 1.47 million residents, of whom 89% are minorities and 29% live below the federal poverty level. In the prior funding period we had a strong track record scientific contributions to the NCORP research bases, and met our accrual targets with exceptionally strong minority participation. In the next funding period, we will continue our strong leadership in cancer therapeutics (EA2165), expand the spectrum of our activities to include new programs in cancer imaging and screening (TMIST), cancer control/prevention (EAZ171), and cancer care delivery research (CCDR). The MMC-Einstein NCORP program is led by faculty with experience in cancer therapeutics and biomarker research (J. Sparano, MD), precision medicine and immunoncology (B. Halmos, MD), and CCDR and cancer prevention/control (B. Rapkin, PhD), and is supported by a cadre of other investigators with a broad range of expertise, some of whom benefited from NCI- funded K12 training program in clinical cancer research.

蒙特菲雷 - 因斯坦少数民族的NCORP社区网站的总体目标是促进 通过参加NCORP的早期和晚期癌症的诊断，预防和管理 作为少数民族/服务不足的社区地点的试验，并在科学和行政上为 NCORP研究基础。这将通过利用Montefiore Health的优势来实现 系统（MHS），包括蒙特菲奥尔医疗中心（MMC），它带来了综合患者的优势 学术医疗中心的护理和创新医疗保健提供系统，主要服务于 少数民族人口和阿尔伯特·爱因斯坦医学与癌症中心（爱因斯坦），这是 通过其NCI-带来培训和教育的力量，以及BASLC，翻译和临床研究 指定的癌症中心。 MMC-Einstein计划还为NCORP带来了关键的领导 研究基础，包括ECOG-ACRIN，Alliance和NRG，包括领导角色 小组主席办公室，科学委员会主席（或联合主席）和协议主席（或联合主席）。我们的计划 基于我们长期参与癌症研究的各个方面的主要成员 ECOG 45年和NCI指定的癌症中心已有48年，并且有少数族裔的历史 应计癌症治疗试验（约占所有患者的65％）。 MMC服务于布朗克斯，这是一个城市社区 147万居民，其中89％是少数民族，29％的居民生活在联邦贫困水平以下。在 以前的资助期我们对NCORP研究基础有很强的往绩科学贡献，并且 以极为强大的少数派参与来满足我们的应计目标。在下一个资金期间，我们将 继续我们在癌症治疗学方面的强大领导（EA2165），将我们的活动的范围扩展到 包括癌症成像和筛查的新计划（TMIST），癌症控制/预防（EAZ171）和 癌症护理分娩研究（CCDR）。 MMC-Einstein NCORP计划由教师领导 癌症治疗和生物标志物研究（J. Sparano，MD），精密医学和 免疫学（MD B. Halmos）和CCDR和癌症预防/对照（B. Rapkin，PhD），IS 在其他具有广泛专业知识的研究人员的支持下，其中一些人受益于NCI- 资助的K12临床癌症研究培训计划。

项目成果

Expanding Criteria for Prognostic Stage IA in Hormone Receptor-Positive Breast Cancer.

扩大激素受体阳性乳腺癌 IA 期预后标准。

• DOI: 10.1093/jnci/djab095
• 发表时间: 2021
• 期刊: Journal of the National Cancer Institute
• 作者: Kantor,Olga;King,TariA;Shak,Steven;Russell,ChristyA;Giuliano,ArmandoE;Hortobagyi,GabrielN;Burstein,HaroldJ;Winer,EricP;Dey,Tanujit;Sparano,JosephA;Mittendorf,ElizabethA
• 通讯作者: Mittendorf,ElizabethA

Lymphovascular invasion, race, and the 21-gene recurrence score in early estrogen receptor-positive breast cancer.

• DOI: 10.1038/s41523-021-00231-x
• 发表时间: 2021-03-01
• 期刊: NPJ breast cancer
• 影响因子: 5.9
• 作者: Makower D;Lin J;Xue X;Sparano JA
• 通讯作者: Sparano JA

Understanding Racial Disparities in Gastrointestinal Cancer Outcomes: Lack of Surgery Contributes to Lower Survival in African American Patients.

• DOI: 10.1158/1055-9965.epi-20-0950
• 发表时间: 2021-03
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Bliton JN;Parides M;Muscarella P;Papalezova KT;In H
• 通讯作者: In H

Systematic Patient Navigation Strategies to Scale Breast Cancer Disparity Reduction by Improved Cancer Prevention and Care Delivery Processes.

系统性患者导航策略通过改进癌症预防和护理服务流程来缩小乳腺癌差异。

• DOI: 10.1200/jop.19.00314
• 发表时间: 2020
• 期刊: JCO oncology practice
• 影响因子: 4
• 作者: Simon,MelissaA;Trosman,JuliaR;Rapkin,Bruce;Rittner,SarahS;Adetoro,Elizabeth;Kirschner,MarcieC;O'Brian,CatherineA;Tom,LauraS;Weldon,ChristineB
• 通讯作者: Weldon,ChristineB

Reply to K. Ando et al.

回复 K. Ando 等人。

• DOI: 10.1200/jco.21.00424
• 发表时间: 2021
• 期刊: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
• 作者: Sparano,JosephA;Crager,MichaelR;Tang,Gong;Gray,RobertJ;Stemmer,SalomonM;Shak,Steven
• 通讯作者: Shak,Steven