Minimal structural strength required in endoluminal devices for aortic aneurysms: mechanisms of rupture when they fail.

主动脉瘤腔内装置所需的最小结构强度：失效时的破裂机制。

• 批准号: nhmrc : 151004
• 负责人: Prof James Semmens
• 金额: $ 6.85万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Development Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/minimal-structural-strength-rupture-fail/80889
• 关键词: Minimal; structural; strength; required; endoluminal

Aneurysmal disease is an age related phenomenon. The mean life expectancy of western populations has doubled in the last 100 years mainly because of the reduction in deaths from occlusive cardiovascular disease. Aneurysmal disease has emerged as a result of the changing pattern of diseases in the community. The impact of this work would be to improve minimally invasive, effective prophylaxis against aneurysm of the abdominal aorta since 80% of those that rupture will result in death. Endoluminal grafting provides a much less invasive procedure and provides an attractive and elegant alternative to open surgery. The general drive in this field is towards miniaturisation. The danger is that structural strengths will be compromised with early failures due to lack of strength; and late failures due to inadequate device durability. This application proposes the development of a collaborative venture with the Department of Vascular Surgery, Royal Perth Hospital, Cook R and D (WA), the Advanced Fluid Dynamics Laboratory (CSIRO, Melbourne) and Centre for Health Services Research (University of WA) to investigate the dynamic flow forces involved in aneurysms of the abdominal aorta. It combines together expertise and facilities to examine the forces acting upon endoluminal stent grafts in pulsatile high pressure environments, the impact on the design, patency, effectiveness and longer-term outcomes. The multidisciplinary team provides a comprehensive approach for this developing area of high technology surgery throughout Australia and internationally. The benefits of this study will directly influence the design and durability of the next generation of endoluminal devices and percutaneous insertions. While Australia is at the forefront of development, its current place in the market can only be maintained by further product development.

动脉瘤疾病是一种与年龄相关的现象。西方人口的平均预期寿命在过去 100 年中翻了一番，主要是因为闭塞性心血管疾病死亡人数的减少。动脉瘤疾病的出现是社区疾病模式变化的结果。这项工作的影响将是改善腹主动脉瘤的微创、有效预防，因为 80% 的腹主动脉瘤破裂会导致死亡。腔内移植提供了一种侵入性小得多的手术，并为开放手术提供了一种有吸引力且优雅的替代方案。该领域的总体驱动力是朝着小型化方向发展。危险在于，由于强度不足，结构强度会因早期失效而受到损害；以及由于设备耐用性不足而导致的晚期故障。该申请建议与血管外科、皇家珀斯医院、库克研发中心（西澳）、高级流体动力学实验室（CSIRO，墨尔本）和健康服务研究中心（西澳大学）建立合作项目，以研究腹主动脉瘤涉及的动态流动力。它结合了专业知识和设施，以检查脉动高压环境中作用于腔内覆膜支架的力，以及对设计、通畅性、有效性和长期结果的影响。多学科团队为整个澳大利亚和国际上高科技手术的这一发展领域提供了全面的方法。这项研究的好处将直接影响下一代腔内装置和经皮插入的设计和耐用性。虽然澳大利亚处于发展的前沿，但其目前的市场地位只能通过进一步的产品开发来维持。