Minimal structural strength required in endoluminal devices for aortic aneurysms: mechanisms of rupture when they fail.

主动脉瘤腔内装置所需的最小结构强度：失效时的破裂机制。

• 批准号: nhmrc : 151004
• 负责人: Prof James Semmens
• 金额: $ 6.85万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Development Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/minimal-structural-strength-rupture-fail/80889
• 关键词: Minimal; structural; strength; required; endoluminal; Minimal; structural; strength; required; endoluminal

Aneurysmal disease is an age related phenomenon. The mean life expectancy of western populations has doubled in the last 100 years mainly because of the reduction in deaths from occlusive cardiovascular disease. Aneurysmal disease has emerged as a result of the changing pattern of diseases in the community. The impact of this work would be to improve minimally invasive, effective prophylaxis against aneurysm of the abdominal aorta since 80% of those that rupture will result in death. Endoluminal grafting provides a much less invasive procedure and provides an attractive and elegant alternative to open surgery. The general drive in this field is towards miniaturisation. The danger is that structural strengths will be compromised with early failures due to lack of strength; and late failures due to inadequate device durability. This application proposes the development of a collaborative venture with the Department of Vascular Surgery, Royal Perth Hospital, Cook R and D (WA), the Advanced Fluid Dynamics Laboratory (CSIRO, Melbourne) and Centre for Health Services Research (University of WA) to investigate the dynamic flow forces involved in aneurysms of the abdominal aorta. It combines together expertise and facilities to examine the forces acting upon endoluminal stent grafts in pulsatile high pressure environments, the impact on the design, patency, effectiveness and longer-term outcomes. The multidisciplinary team provides a comprehensive approach for this developing area of high technology surgery throughout Australia and internationally. The benefits of this study will directly influence the design and durability of the next generation of endoluminal devices and percutaneous insertions. While Australia is at the forefront of development, its current place in the market can only be maintained by further product development.

动脉瘤是与年龄有关的现象。在过去的100年中，西方人口的平均预期寿命翻了一番，这主要是因为闭塞性心血管疾病的死亡减少。由于社区中疾病的模式变化，动脉瘤疾病已经出现。这项工作的影响是改善针对腹主动脉动脉瘤的微创，有效的预防，因为破裂的人中有80％会导致死亡。内部嫁接提供了较小的侵入性手术，并为开放手术提供了一种吸引人而优雅的替代方法。该领域的一般驱动是迈向小型化。危险在于，由于缺乏力量，结构优势将因早期失败而受到损害。以及由于设备耐用性不足而导致的较晚故障。该应用程序建议与血管外科系，皇家珀斯医院，库克R和D（WA），先进的流体动力学实验室（CSIRO，墨尔本）和卫生服务研究中心（WA）（University of WA）一起研究涉及腹部ARORTA AneurySms涉及的动态流动力的合作企业。它结合了专业知识和设施，以检查在脉动高压环境中作用于内胚骨支架移植物的力，对设计，通畅，有效性和长期结果的影响。多学科团队为整个澳大利亚和国际上的高科技手术发展领域提供了一种全面的方法。这项研究的好处将直接影响下一代内部设备和经皮插入的设计和耐用性。尽管澳大利亚处于发展的最前沿，但其目前在市场上的地位只能通过进一步的产品开发来维持。