ENDOPHTHALMITIS IN WESTERN AUSTRALIA (1980-2002): INCIDENCE, MANAGEMENT AND EFFECTIVENESS OF CHEMOPROPHYLAXIS

西澳大利亚州的眼内炎（1980-2002 年）：发病率、治疗和化学预防的有效性

• 批准号: nhmrc : 110250
• 负责人: Prof James Semmens
• 金额: $ 23.27万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/endophthalmitis-western-australia-effectiveness-chemoprophylaxis/80809
• 关键词: ENDOPHTHALMITIS; WESTERN; AUSTRALIA; 1980; 2002

Endophthalmitis is a serious sight threatening infection of the internal cavities of the eye. Although endophthalmitis is not a common post-operative complication of eye surgery, 200 cases of this serious sight threatening infection occur each year in Australia following cataract surgery. Not only is this condition extremely distressing to the patients and surgeons alike, around A$4 million per year is spent each year treating the infection. Also, there is significant expenditure on methods to prevent the infection that have not, as yet, been demonstrated beneficial. Our study will use a multidisciplinary team consisting of consultant ophthalmologists, public health researchers, a biostatistician and health economist to assess the impact of endophthalmitis in WA from 1980-2002 (around 480 cases). The population-based WA Linked Database provides a unique opportunity to produce what will be the largest population study of endophthalmitis. Data from the study will provide important information to develop best-practice treatment guidelines to prevent endophthalmitis following cataract surgery. The significance of this study will be that accurate information on the clinical epidemiology and true cost of endophthalmitis will be obtained for WA. By studying the records of patients with endophthalmitis and comparing them with matched patients, who did not have post-operative endophthalmitis following cataract surgery, we will characterise the risks for this severe complication by identifying the underlying factors that are responsible for the infection. We will also better understand the effect of methods used to prevent the infection. The use of a whole population-based study to assess methods of endophthalmitis prevention has not been done before and will have a significant beneficial impact on health policy and best-practice, not only in Australia, but also internationally.

内pythmitis是一种严重的视力，威胁着眼睛内部空腔的感染。尽管内脑炎不是眼科手术的常见术后并发症，但每年在白内障手术后，每年在澳大利亚发生200例严重的视力威胁感染。这种情况不仅使患者和外科医生都极为痛苦，每年每年花费约400万美元来治疗感染。同样，关于防止感染的方法还没有大量支出，但尚未证明有益。我们的研究将使用由顾问眼科医生，公共卫生研究人员，生物统计学家和健康经济学家组成的跨学科团队，以评估1980 - 2002年从1980 - 2002年开始的WA内恐惧症的影响（约480例）。基于人群的WA链接数据库提供了一个独特的机会，可以产生最大的人群研究。该研究的数据将提供重要的信息，以制定最佳实践治疗指南，以防止白内障手术后内脑炎。这项研究的重要性是，将获得有关WA的临床流行病学和真实成本的准确信息。通过研究内咽炎的患者的记录，并将其与匹配的患者进行比较，这些患者在白内障手术后没有术后内脑炎，我们将通过识别导致感染的基本因素来表征这种严重并发症的风险。我们还将更好地了解用于防止感染的方法的效果。以前尚未进行整个基于人群的研究来评估预防内嗜性疾病的方法，并且将对卫生政策和最佳实践产生重大的有益影响，不仅在澳大利亚，而且在国际上。