The effect of stress/strain and fatigue fracture sites on durability of modular aortic endografts and arterial walls

应力/应变和疲劳断裂部位对模块化主动脉内移植物和动脉壁耐久性的影响

• 批准号: nhmrc : 254541
• 负责人: Prof James Semmens
• 金额: $ 20.07万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Development Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/effect-stressstrain-fatigue-arterial-walls/100147
• 关键词: effect; stress; strain; fatigue; fracture

Aneurysmal disease is an age related phenomenon. The mean life expectancy of western populations has doubled in 100 years because of the reduction in deaths from preventable and treatable diseases, and prolongation of life with chronic and incurable diseases. The older community (>65 years) continues to be active and productive contrary to prior predictions. Aneurysmal disease has emerged as a result of the changing pattern of diseases in the community. As with many other diseases, prophylaxis against aneurysmal disease is the most effective approach since 80% of those that rupture will result in death. Endoluminal grafting provides a much less invasive procedure and provides an attractive and elegant alternative to open surgery. The danger is that structural strengths will be compromised with failures due to lack of strength and inadequate device durability. The most practical endografts are those that are built up from modules but vulnerable sites affected by fatiguing and disruptive forces are being identified, in particular where a tube divides into two outflow channels – the bifurcation - and joins. To improve and protect the current device, and enable sound engineering for future devices, we need to know the nature, magnitude and location of these forces. The existing collaboration with medical specialist, Cook Aust., the Advanced Fluid Dynamics Laboratory (CSIRO, Melb.) and University of WA combines a multidisciplinary team working towards the design and durability of the next generation of endoluminal devices and percutaneous insertions. While Australia is at the forefront of development, its current place in the market can only be maintained by further product development. Optimising and improving endoluminal grafts will reduce the suffering of major surgery while prolonging a higher quality of life with a much less invasive procedure whose long-term effectiveness, and thereby acceptance is dependent upon reliable durability.

动脉瘤疾病是一种与年龄相关的现象，由于可预防和可治疗疾病的死亡人数减少，以及老年人群（>65 岁）的寿命延长，西方人口的平均预期寿命增加了一倍。与之前的预测相反，动脉瘤疾病的出现是由于社区疾病模式的变化，与许多其他疾病一样，预防动脉瘤疾病是最重要的。这是最有效的方法，因为 80% 的破裂会导致死亡，腔内移植提供了一种侵入性小得多的手术，并且提供了一种有吸引力且优雅的替代开放手术的方法，但危险在于由于缺乏强度而导致结构强度受损。最实用的内移植物是由模块构建的内移植物，但正在确定受疲劳和破坏力影响的脆弱部位，特别是在管分成两个流出通道（分叉处）并连接的地方。为了改进和保护当前的设备，并为未来的设备提供良好的工程支持，我们需要了解这些力的性质、大小和位置。 .）和西澳大学联合了一个多学科团队，致力于下一代腔内设备和经皮插入的设计和耐用性。虽然澳大利亚处于开发的前沿，但其目前的市场地位只能通过进一步的产品开发来维持。优化与改进腔内移植物将减少大手术的痛苦，同时通过侵入性小得多的手术延长更高的生活质量，其长期有效性和接受度取决于可靠的耐用性。