PHENOTYPE GENOTYPE PROJECT IN ADDICTION AND MOOD DISORDERS

成瘾和情绪障碍的表型基因型项目

• 批准号: 7607061
• 负责人: HANS C BREITER
• 金额: $ 1.8万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607061
• 关键词: Base of the Brain; Computer Retrieval of Information on Scientific Projects Database; Disease; Extended Family; Functional Magnetic Resonance Imaging; Funding; Genetic; Genetic Polymorphism; Genotype; Goals; Grant; Heritability; Institution; Link; Mental Depression; Mood Disorders; Phase; Phenotype; Predisposition; Psychostimulant dependence; Research; Research Personnel; Resistance; Resources; Source; United States National Institutes of Health; addiction; base; endophenotype; member; neuroimaging; neuropsychiatry

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this Phenotype-Genotype Project in Addictions and Mood Disorders is to understand the genetic bases for the brain circuitry alterations conferring susceptibility or resistance to stimulant dependence and depression. The initial phase of this project will characterize neuroimaging-based markers of these illnesses in multiple members of extended families so as to establish their familiality/heritability. A subsequent phase of this project will, once further funding is obtained, seek to identify the genetic bases of addiction and depression. To derive circuitry-based endophenotypes for addiction and depression, we will employ morphometric and functional magnetic resonance imaging (mMRI and fMRI). This study aims to delineate a set of psychiatric phenotypes and circuitry-based endophenotypes in 900 subjects. Once endophenotypic markers associated with these neuropsychiatric diseases have been characterized, we will then look to link genetic polymorphisms.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这种表型基因型项目在成瘾和情绪障碍中的总体目标是了解脑回路改变的遗传基础，从而赋予易感性或对刺激依赖性和抑郁症的抗性。 该项目的初始阶段将在大家庭的多个成员中表征这些疾病的基于神经成像的标记，以建立其家族性/遗传力。一旦获得了进一步的资金，该项目的随后阶段将寻求确定成瘾和抑郁症的遗传基础。为了得出基于电路的内表型成瘾和抑郁型，我们将采用形态和功能性磁共振成像（MMRI和fMRI）。这项研究旨在描绘900名受试者中的一组精神病表型和基于电路的内表型。一旦与这些神经精神疾病相关的内型型标记已被表征，我们将寻求将遗传多态性联系起来。